Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Norman Y. Liaw"'
Autor:
Rosa Kim, Sebastian H. Nagel, Norman Y. Liaw, Wolfram-H. Zimmermann, Laura C. Zelarayán, Eric Schoger
Publikováno v:
Stem Cell Research, Vol 80, Iss , Pp 103531- (2024)
The fluorescence ubiquitination cell cycle inhibitor (FUCCI) has been introduced to monitor cell cycle activity in living cells, including human induced pluripotent stem cells (hiPSC) and derived cell types. We have recently developed hiPSC with stab
Externí odkaz:
https://doaj.org/article/2b3852c304e44b4788130954deeeac66
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100032- (2020)
Summary: This protocol describes a robust method for the generation of engineered human myocardium (EHM) from pluripotent stem cells (PSCs) in a multi-well plate under defined, serum-free conditions. By parallel culture of up to 48 EHM in one plate,
Externí odkaz:
https://doaj.org/article/abf685c7361d4a15993918d6b9fbc708
Autor:
Moritz Matthaei, Tahnee Kennedy, Mala Gunadasa-Rohling, Cristina Villa del Campo, Paul R. Riley, Norman Y. Liaw, Luca Braga, Wolfram-Hubertus Zimmermann, Mauro Giacca, Niels Voigt, Gabriela Salinas
Publikováno v:
Cardiovascular Research
Aims After a myocardial infarction, the adult human heart lacks sufficient regenerative capacity to restore lost tissue, leading to heart failure progression. Finding novel ways to reprogram adult cardiomyocytes into a regenerative state is a major t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc404eb1d3204d6e75b766cdf8938ca7
https://doi.org/10.1093/cvr/cvab054
https://doi.org/10.1093/cvr/cvab054
Autor:
Naim Kittana, Gabriela L. Santos, Susanne Lutz, Wolfram-Hubertus Zimmermann, Norman Y. Liaw, Mohyeddin Assali, Abdul Rehman
Publikováno v:
International Journal of Nanomedicine
Naim Kittana, 1 Mohyeddin Assali, 2 Wolfram-Hubertus Zimmermann, 3, 4 Norman Liaw, 3, 4 Gabriela Leao Santos, 3, 4 Abdul Rehman, 3, 4 Susanne Lutz 3, 4 1Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, An-Najah National Unive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eba717ddd196f99494c4b3cf4950f1c
https://doi.org/10.2147/ijn.s289107
https://doi.org/10.2147/ijn.s289107
Autor:
Laura C Zelarayan, Eva Wagner, Wolfram-Hubertus Zimmermann, Enno Klussmann, Norman Y. Liaw, Lavanya M Iyer, Claudia Noack, Kerstin Zuehlke, Eric Schoger
Publikováno v:
Circulation Research. 125
Integrative biochemical and omic-based approaches have refined our understanding of how cells integrate the Wnt signal at the chromatin level to yield specific cellular responses. However, this aspect remains unexplored in the heart. Since Wnt/β-cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79265410c0da0dce2aa3e4c0330e7941
https://doi.org/10.1161/res.125.suppl_1.377
https://doi.org/10.1161/res.125.suppl_1.377
Autor:
John McAnally, Lavanya M Iyer, Eric Schoger, Rhonda Bassel-Duby, Wei Tan, Laura C Zelarayan, Kelli J. Carroll, Claudia Noack, Wolfram H. Zimmermann, Norman Y. Liaw
Publikováno v:
Circulation Research. 125
Cardiac remodelling is accompanied by silencing of genes necessary for cardiac homeostasis including Krüppel-like factor 15 ( Klf15 ), an anti-hypertrophic factor. Due to a lack of tools for gene activation, we aim to adapt a CRISPR-based approach f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d8f54e9e7d33385a8d7daf33e9c7a44
https://doi.org/10.1161/res.125.suppl_1.372
https://doi.org/10.1161/res.125.suppl_1.372
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Pyruvate dehydrogenase (PDH) complex, a multienzyme complex at the nexus of glycolytic and Krebs cycles, provides acetyl-CoA to the Krebs cycle and NADH to complex I thus supporting a critical role in mitochondrial energy production and cellular surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ca4ffe7f7eb571f15cb6b8889f4562
http://europepmc.org/articles/PMC6383428
http://europepmc.org/articles/PMC6383428
Autor:
Gerd Hasenfuß, Lavanya M Iyer, Hendrik Milting, Samuel Sossalla, Eva Wagner, Wolfram-Hubertus Zimmermann, Maria-Patapia Zafiriou, Norman Y. Liaw, Monique Woelfer, Eric Schoger, Sara Khadjeh, Laura C Zelarayan, Katrin Streckfuss-Boemeke, Claudia Noack
Background The combination of cardiomyocyte (CM) and vascular cell (VC) fetal reprogramming upon stress culminates in end-stage heart failure (HF) by mechanisms that are not fully understood. Previous studies suggest KLF15 as a key regulator of CM hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabebe7cd4393ddc7d2426fd62eb16df
http://resolver.sub.uni-goettingen.de/purl?gs-1/16513
http://resolver.sub.uni-goettingen.de/purl?gs-1/16513
Autor:
Yu Zhang, Norman Y. Liaw, Jay W. Schneider, Eric N. Olson, Malte Tiburcy, Cristina Rodriguez-Caycedo, John M. Shelton, Chengzu Long, Wolfram-Hubertus Zimmermann, Rhonda Bassel-Duby, Hui Li, Huanyu Zhou, Pradeep P.A. Mammen, Yi Li Min, Viktoriia Kyrychenko
Publikováno v:
Science Advances
CRISPR-mediated genome editing efficiently corrected cardiac abnormalities associated with DMD in human engineered heart tissue.
Genome editing with CRISPR/Cas9 is a promising new approach for correcting or mitigating disease-causing mutations.
Genome editing with CRISPR/Cas9 is a promising new approach for correcting or mitigating disease-causing mutations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b1fb73c74f1ee3de08568327f19243
https://doi.org/10.1126/sciadv.aap9004
https://doi.org/10.1126/sciadv.aap9004
Autor:
Jelena R. Ghadri, Isabel N. Schellinger, Bernd Wollnik, Mia Aurelia Huber, Thomas F. Lüscher, Ralf Dressel, Samuel Sossalla, Malte Tiburcy, Wolfram-Hubertus Zimmermann, Uwe Raaz, Tuan-Dinh D. Lam, Daniela Hübscher, Celina Isabell Guessoum, Katrin Streckfuss-Bömeke, Thomas Borchert, Holger Thiele, Gerd Hasenfuss, Yun Li, Viacheslav O. Nikolaev, Benjamin Meder, Jan Haas, Norman Y. Liaw, Lukas Cyganek, Claudius Jacobshagen, Christian Templin, Kaomei Guan
Background Takotsubo syndrome (TTS) is characterized by an acute left ventricular dysfunction and is associated with life-threating complications in the acute phase. The underlying disease mechanism in TTS is still unknown. A genetic basis has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9297a648023f1f6d926586076c40488
http://resolver.sub.uni-goettingen.de/purl?gs-1/16489
http://resolver.sub.uni-goettingen.de/purl?gs-1/16489