Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Norman Y. Garceau"'
Autor:
Reiko Shinkura, Norman Y. Garceau, Yoko Kosaka, Tasuku Honjo, Randolph J. Noelle, John E. Hambor, Sally R. Masters
Publikováno v:
The Journal of Experimental Medicine
CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df0a8086c5e59b3b09f20f9959c0beb
https://doi.org/10.1084/jem.191.2.381
https://doi.org/10.1084/jem.191.2.381
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 94(8), 3877-3882. NATL ACAD SCIENCES
The circadian oscillator in Neurospora is a negative feedback loop involving as principal players the products of the frequency ( frq ) locus. frq encodes multiple forms of its protein product FRQ, which act to depress the amounts of frq transcript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a54a58f41420baa612b53ed97a456f
https://doi.org/10.1073/pnas.94.8.3877
https://doi.org/10.1073/pnas.94.8.3877
Publikováno v:
Journal of Genetics. 75:387-401
Endogenous circadian clocks, present in both prokaryotes and eukaryotes, provide the machinery by which organisms keep in synchrony with the external world. The ability of the clock to measure accurate time allows changes in the environment (particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::713909ceca4f429f8cf8e81a2c4c87a3
https://doi.org/10.1007/bf02966317
https://doi.org/10.1007/bf02966317
Autor:
A. Samuel Vellekoop, Douglas A. Otte, R. J. Chambers, Norman Y. Garceau, David A. Tess, Ajith V. Kamath, Christopher M. Manley, Alissa L. Sheils, Susan C. Lilley, Kelvin Lam, Dennis O. Scott, Kristin Abrams, Yan Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(2)
Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd92f67fa405782ff8ca80f9872d12b
https://pubmed.ncbi.nlm.nih.gov/16275071
https://pubmed.ncbi.nlm.nih.gov/16275071
Publikováno v:
Cell. 89(3)
Two forms of FRQ, a central component of the Neurospora circadian clock, arise through alternative in-frame initiation of translation. Either form alone suffices for a functional clock at some temperatures, but both are always necessary for robust rh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df40ed1ee6655ecf380b4d1e3779194c
https://pubmed.ncbi.nlm.nih.gov/9150147
https://pubmed.ncbi.nlm.nih.gov/9150147
Autor:
Ryan W. Clinton, Deanna Navaroli, Edward A. Esposito, Kerrin Beovich, Kelvin Lam, Norman Y. Garceau
Publikováno v:
Cancer Research. 73:4544-4544
Vascular endothelial growth factor (VEGF) is potent mitogen for endothelial cells that signals through VEGF Receptor-type2 (VEGFR-2)/Flk-1/KDR. Binding of VEGF to VEGFR-2, a membrane bound receptor tyrosine kinase of the VEGF-receptor family, leads t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cf6a869fc2752ef4759c639ea1217ce
https://doi.org/10.1158/1538-7445.am2013-4544
https://doi.org/10.1158/1538-7445.am2013-4544
Autor:
Hyeseon Cho, Jay C. Dunlap, Susan K. Crosthwaite, Jennifer J. Loros, Martha Merrow, Deborah Bell-Pedersen, Chenghua Luo, Mari L. Shinohara, Norman Y. Garceau
A great deal is known about this archetypal circadian system, and it is likely that Neurospora will represent the first circadian system in which it will be possible to provide a complete description of the flow of information from the photoreceptor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae7492aa839d707586b381c765f9a91d
https://doi.org/10.1016/s0079-6123(08)60397-0
https://doi.org/10.1016/s0079-6123(08)60397-0
Autor:
Deborah Bell-Pedersen, Jay C. Dunlap, Jennifer J. Loros, Susan K. Crosthwaite, Martha Merrow, Kristin Lindgren, Norman Y. Garceau, Keith A. Johnson, Benjamin D. Aronson
Publikováno v:
Circadian Clocks and their Adjustment, 3-25
ISSUE=183;STARTPAGE=3;ENDPAGE=25;TITLE=Circadian Clocks and their Adjustment
Ciba Foundation Symposium 183-Circadian Clocks and their Adjustment
ISSUE=183;STARTPAGE=3;ENDPAGE=25;TITLE=Circadian Clocks and their Adjustment
Ciba Foundation Symposium 183-Circadian Clocks and their Adjustment
Genetic approaches to the identification of clock components have succeeded in two model systems, Neurospora and Drosophila. In each organism, genes identified through screens for clock-affecting mutations (frq in Neurospora, per in Drosophila) have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1a549b1d40371d420d2cef9d7aad0d
https://research.rug.nl/en/publications/9bb589fa-be22-40dc-a5f4-8e9080d8dbed
https://research.rug.nl/en/publications/9bb589fa-be22-40dc-a5f4-8e9080d8dbed
Publikováno v:
Cancer Research. 72:2842-2842
Tropomyosin-related kinases (Trks A, B, and C) are a family of membrane-associated receptor tyrosine kinases (RTKs) activated by neurotrophins. RTKs are shown to be implicated in Alzheimer's disease, depression, pain sensation and various cancers inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19644618641de6fd6e43e79b480af69a
https://doi.org/10.1158/1538-7445.am2012-2842
https://doi.org/10.1158/1538-7445.am2012-2842