Zobrazeno 1 - 10 of 37 pro vyhledávání: '"Norman W. Gilman"'
1
Atropisomers of 1,4-benzodiazepines. 2. Synthesis and resolution of imidazo[1,5-a][1,4]benzodiazepines
Autor: Norman W. Gilman, Louis J. Todaro, James Valentine Earley, John F. Blount, Perry Rosen, Charles M. Cook
Publikováno v: The Journal of Organic Chemistry. 58:3285-3298
The resolution of the 1-tert-butylimidazo[1,5-a] [1,4]benzodiazepines 12, 25, and 31 is described. These compounds do not contain a center of symmetry but exist as conformational isomers due to the presence of a chiral plane. The resolution was carri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ab9569df3706a69f309aa40833e92ec
https://doi.org/10.1021/jo00064a014
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5
Synthesis of Acetylenic Carboxylic Acids
Autor: B. C. Holland, Norman W. Gilman
Publikováno v: Synthetic Communications. 4:199-202
A recent communication by Brattesani and Heathcock1 on the alkylation of acetylenes with alkyl halides in hexamethylphosphoramide (HMPA) prompts us to report our work which is of a similar nature. We were interested in preparing acetylenic acids of f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::392ca3335d27d9158f00a8982769a744
https://doi.org/10.1080/00397917408062072
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6
Charge transfer mechanism for benzodiazepine (BZ) action
Autor: Philip W. Crawford, Michael D. Ryan, Peter Kovacic, Norman W. Gilman
Publikováno v: Bioelectrochemistry and Bioenergetics. 16:407-426
A novel mechanism for BZ action is proposed in which a BZ is protonated by GABA or protein RNH3+ to yield an iminium species that is responsible for drug activity via charge transfer (c.t.). The following evidence from our work and prior studies supp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::382ffd943918da94be023cbc707e4596
https://doi.org/10.1016/0302-4598(86)80063-0
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8
Quinazolines and 1,4-benzodiazepines. LXXVIII Pyrazolo[1,5-a] [1,4]-benzodiazepines and Imidazo[1,5-a] [1,4]benzodiazepinones
Autor: Norman W. Gilman, Betty C. Holland, R. Ian Fryer
Publikováno v: Journal of Heterocyclic Chemistry. 14:1163-1169
The syntheses of novel 8-chloropyrazolo[1,5-a][1,4]benzodiazepines and of an imidazo-benzodiazepinone utilizing products from the nucleophilic substitution of fluorine in 2-fluoro-5-nitrobenzophenone (1) by pyrazole-3,5-dicarboxylic acid, dimethyl es
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::275e50a0291623526ebe4d356f1f7783
https://doi.org/10.1002/jhet.5570140708
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9
Nucleophilic displacement of aromatic fluorine. Part V. Use of nitrogen heterocycles as nucleophiles
Autor: R. Ian Fryer, Norman W. Gilman, Gregory R. Walsh, Betty C. Holland
Publikováno v: Journal of Heterocyclic Chemistry. 14:1157-1162
The scope of the nucleophilic displacement of aromatic halogens on 1,4-benzodiazepine precursors by the anions of pyrroles, pyrazoles and imidazoles was studied both with and without electron-withdrawing substitutents on the heterocyclic nucleophiles
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a7347dde8053e630e1e38c4742867f9
https://doi.org/10.1002/jhet.5570140707
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10
Synthesis of pyridazino[1,6-a]benzimidazoles
Autor: Norman W. Gilman, L. E. Benjamin, James Valentine Earley
Publikováno v: Journal of Heterocyclic Chemistry. 23:119-124
The synthesis of eight pyridazino[1,6-a]benzimidazoles by a novel synthetic route is described. This relatively unexplored heterocyclic ring system is readily accessible starting from benzoylpropionic acids and phenylhydrazines in five steps. The int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0062e6a4bb4c215d3eb9df597f11895f
https://doi.org/10.1002/jhet.5570230124
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