Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Norman Rahnis"'
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans
Autor:
Samim Sharifi, Prerana Chaudhari, Asya Martirosyan, Alexander Otto Eberhardt, Finja Witt, André Gollowitzer, Lisa Lange, Yvonne Woitzat, Eberechukwu Maryann Okoli, Huahui Li, Norman Rahnis, Joanna Kirkpatrick, Oliver Werz, Alessandro Ori, Andreas Koeberle, Holger Bierhoff, Maria Ermolaeva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Ribosome biogenesis is initiated by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal RNA (pre-rRNA). Pol I activity was previously linked to longevity, but the underlying mechanisms were not studied beyond effects on nucleolar st
Externí odkaz:
https://doaj.org/article/e8c06c7d253c4ce7a8ddf6f0c29bac62
Autor:
Dario Lucas Helbing, Fabienne Haas, Emilio Cirri, Norman Rahnis, Therese Thuy Dung Dau, Erika Kelmer Sacramento, Nova Oraha, Leopold Böhm, Trim Lajqi, Pascal Fehringer, Helen Morrison, Reinhard Bauer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Preconditioning with lipopolysaccharide (LPS) induces neuroprotection against subsequent cerebral ischemic injury, mainly involving innate immune pathways. Microglia are resident immune cells of the central nervous system (CNS) that respond early to
Externí odkaz:
https://doaj.org/article/af9983664f5e42a9b7a04451c7f45560
Autor:
Katjana Schwab, Luis Coronel, Konstantin Riege, Erika K. Sacramento, Norman Rahnis, David Häckes, Emilio Cirri, Marco Groth, Steve Hoffmann, Martin Fischer
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that RFX7 may also have a role in neurological and metabolic disorders. We recently reported that RFX7 res
Externí odkaz:
https://doaj.org/article/49b81b484eb94360a680e1b62c99d075
Autor:
Lisa Marx-Blümel, Christian Marx, Jürgen Sonnemann, Frank Weise, Jörg Hampl, Jessica Frey, Linda Rothenburger, Emilio Cirri, Norman Rahnis, Philipp Koch, Marco Groth, Andreas Schober, Zhao-Qi Wang, James F. Beck
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Hematopoietic stem cell (HSC) transplantation is successfully applied since the late 1950s. However, its efficacy can be impaired by insufficient numbers of donor HSCs. A promising strategy to overcome this hurdle is the use of an advanced e
Externí odkaz:
https://doaj.org/article/c3458d44a6a74132a128e0b81a5e3c4c
Autor:
Dario Lucas Helbing, Fabienne Haas, Emilio Cirri, Norman Rahnis, Therese Thuy Dung Dau, Erika Kelmer Sacramento, Nova Oraha, Leopold Böhm, Helen Morrison, Reinhard Bauer
Preconditioning with LPS induces neuroprotection against subsequent cerebral ischemic injury, mainly involving innate immune pathways. Microglia are CNS-resident immune cells that respond early to danger signals through memory-like differential repro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32dee96512b5d81e51b2b912c43622d2
https://doi.org/10.1101/2023.04.13.536755
https://doi.org/10.1101/2023.04.13.536755
Autor:
Katjana Schwab, Luis Coronel, Konstantin Riege, Erika K. Sacramento, Norman Rahnis, David Häckes, Emilio Cirri, Marco Groth, Steve Hoffmann, Martin Fischer
Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that RFX7 may also have a role in neurological and metabolic disorders. We recently reported that RFX7 responds to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d0078a83c5e50a718a77a5c215ab6e
https://doi.org/10.1101/2022.12.05.519097
https://doi.org/10.1101/2022.12.05.519097
Autor:
Norman Rahnis, Alexander Dakhovnik, Maria Ermolaeva, Prerana Chaudhari, Joanna Kirkpatrick, Lilia Espada, Ashish Nair, Tetiana Poliezhaieva, Oliver Werz, Asya Martirosyan, Laura Miek, Nadia Döring, Yvonne Schaub, Andreas Koeberle, Alessandro Ori
Publikováno v:
Nature metabolism. 2(11)
Current clinical trials are testing the life-extending benefits of the diabetes drug metformin in healthy individuals without diabetes. However, the metabolic response of a non-diabetic cohort to metformin treatment has not been studied. Here, we sho
Autor:
Lonny Jürgensen, Moritz H Kern, Eva Riechert, Hugo A. Katus, Agniezka A Gorska, Joanna Kirkpatrick, Mirko Völkers, Thanh Cao Ho, C. S. Hofmann, Kira Gür, Norman Rahnis
Publikováno v:
Circulation Research. 125
Background: The mammalian target of Rapamycin complex 1 (mTORC1) increases cell size by initiating translation as well as by inhibiting catabolic functions such as proteolysis or autophagy. We have previously proposed Proline-rich Akt substrate 1 (Pr