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Akademický článek

Small molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria

Autor: Rachel Bargabos, Akira Iinishi, Bryson Hawkins, Thomas Privalsky, Norman Pitt, Sangkeun Son, Rachel Corsetti, Michael F. Gates, Ryan D. Miller, Kim Lewis

Publikováno v: mBio, Vol 15, Iss 10 (2024)

ABSTRACT We report the identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of Photorhabdus and Xenorhabdus, whose symbiotic relationship with eukaryotic nematodes favors secondary metabolites that meet several requirements matching th

Externí odkaz: https://doaj.org/article/7b24fee40a7c4d60acadd20f7714785a

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Akademický článek

A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients

Autor: Madeleine Morrissette, Norman Pitt, Antonio González, Philip Strandwitz, Mariaelena Caboni, Alison W. Rebman, Rob Knight, Anthony D’Onofrio, John N. Aucott, Mark J. Soloski, Kim Lewis

Publikováno v: mBio, Vol 11, Iss 5 (2020)

ABSTRACT Lyme disease is the most common vector-borne disease in the United States, with an estimated incidence of 300,000 infections annually. Antibiotic intervention cures Lyme disease in the majority of cases; however, 10 to 20% of patients develo

Externí odkaz: https://doaj.org/article/6ce4b7f151484fb790e5b749f9d0ebd2

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Efficacy of a Novel, Native Microbial Feed Supplement on the Mitigation of Necrotic Enteritis in Cobb 500 Broiler Chickens

Autor: Andrew Izzo, Grant Gogul, Josh Lefler, Allison Wells, James Gaffney, Jennifer Cao, Norman Pitt, Brian Dirks, Mallory Embree

Publikováno v: International Journal of Poultry Science. 21:57-64

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9633f603654f8088cefcc6fa1ea627b
https://doi.org/10.3923/ijps.2022.57.64

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Computational identification of a systemic antibiotic for gram-negative bacteria

Publikováno v: Nature microbiology. 7(10)

Discovery of antibiotics acting against Gram-negative species is uniquely challenging due to their restrictive penetration barrier. BamA, which inserts proteins into the outer membrane, is an attractive target due to its surface location. Darobactins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c797093054e197dc1d0d3e3fbf7d1f5
https://pubmed.ncbi.nlm.nih.gov/36163502

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A Selective Antibiotic for Lyme Disease

Publikováno v: Cell

Summary Lyme disease is on the rise. Caused by a spirochete Borreliella burgdorferi, it affects an estimated 500,000 people in the United States alone. The antibiotics currently used to treat Lyme disease are broad spectrum, damage the microbiome, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab36912358f165c45496478ef1f5dc1
https://europepmc.org/articles/PMC8526400/

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A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients

Autor: Mark J. Soloski, Anthony D'Onofrio, Philip Strandwitz, Alison W. Rebman, Antonio Gonzalez, Mariaelena Caboni, Madeleine Morrissette, John N. Aucott, Rob Knight, Norman Pitt, Kim Lewis

Publikováno v: mBio, Vol 11, Iss 5 (2020)
mBio
mBio, vol 11, iss 5

Most patients with acute Lyme disease are cured with antibiotic intervention, but 10 to 20% endure debilitating symptoms such as fatigue, neurological complications, and myalgias after treatment, a condition known as posttreatment Lyme disease syndro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4736562826b7ad293c19454b0523a04d
https://journals.asm.org/doi/10.1128/mBio.02310-20

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