Výsledky vyhledávání - "Norman N. Iscove"

Akademický článek

Microdroplet-based one-step RT-PCR for ultrahigh throughput single-cell multiplex gene expression analysis and rare cell detection

Autor: Jennifer Ma, Gary Tran, Alwin M. D. Wan, Edmond W. K. Young, Eugenia Kumacheva, Norman N. Iscove, Peter W. Zandstra

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)

Abstract Gene expression analysis of individual cells enables characterization of heterogeneous and rare cell populations, yet widespread implementation of existing single-cell gene analysis techniques has been hindered due to limitations in scale, e

Externí odkaz: https://doaj.org/article/7d74cd66adde492b8a0fdeaee7a2b336

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Akademický článek

cDNAs Generated from Individual Epidermal Cells Reveal that Differential Gene Expression Predicting Subsequent Resistance or Susceptibility to Rust Fungal Infection Occurs Prior to the Fungus Entering the Cell Lumen

Autor: Michael J. R. Mould, Tao Xu, Mary Barbara, Norman N. Iscove, Michèle C. Heath

Publikováno v: Molecular Plant-Microbe Interactions, Vol 16, Iss 9, Pp 835-845 (2003)

As the cowpea rust fungus penetrates the wall of a cowpea epidermal cell, resistant and susceptible plants exhibit different ultrastructural and cytochemical changes within the epidermal protoplast. To examine plant gene expression at this stage of i

Externí odkaz: https://doaj.org/article/a65d28d4a18642629b02e980f90d667d

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Realization of the T Lineage Program Involves GATA-3 Induction of Bcl11b and Repression of Cdkn2b Expression

Autor: Patrycja K. Thompson, Edward L. Y. Chen, Renée F. de Pooter, Catherine Frelin, Walter K. Vogel, Christina R. Lee, Thomas Venables, Divya K. Shah, Norman N. Iscove, Mark Leid, Michele K. Anderson, Juan Carlos Zúñiga-Pflücker

Publikováno v: J Immunol

The zinc-finger transcription factor GATA-3 plays a crucial role during early T cell development and also dictates later T cell differentiation outcomes. However, its role and collaboration with the Notch signaling pathway in the induction of T linea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6731af602c9d0cd8173503c1d6e959
https://doi.org/10.4049/jimmunol.2100366

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Data from OLIG2 (BHLHB1), a bHLH Transcription Factor, Contributes to Leukemogenesis in Concert with LMO1

Autor: Peter D. Aplan, Christopher Slape, Stephen D. Nimer, Norman N. Iscove, Mary Barbara, Ramona Deveney, Ying-Wei Lin

OLIG2 (originally designated BHLHB1) encodes a transcription factor that contains the basic helix-loop-helix motif. Although expression of OLIG2 is normally restricted to neural tissues, overexpression of OLIG2 has been shown in patients with precurs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c007920e5206d78836ad4e6eef6d09ca
https://doi.org/10.1158/0008-5472.c.6493604

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Committed Hemopoietic Progenitors, Not Stem Cells, are the Principal Responders to Hox Gene Transduction

Autor: Mary Barbara, Guy Sauvageau, Patricia Benveniste, Catherine Frelin, Salima Janmohamed, Juan Carlos Zúñiga-Pflücker, Deborah Hyam, Christopher J. Paige, Harvey Lim, Jana Krosl, Robert Herrington, Norman N. Iscove, Carol Stocking

As hemopoietic stem cells differentiate, their proliferative lifespan shortens by unknown mechanisms. Homeobox cluster (Hox) genes have been implicated by their enhancement of self-renewal when transduced into hemopoietic cells, but gene deletions ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75342029e11997f9057d81f9a072b752

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Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

Publikováno v: Science. 345:1509-1512

Human adult stem cell expansion Transfused blood saves lives. Despite the widespread use of this critical resource, it is difficult to increase blood cell numbers outside of the body. By screening thousands of small compounds, Fares et al. identify a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ead3cb09e78931d09f85745a5a94902
https://doi.org/10.1126/science.1256337

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GATA-3 REGULATES THE SELF-RENEWAL OF LONG-TERM HEMATOPOIETIC STEM CELLS

Autor: Abdallah Souabni, Juan Carlos Zúñiga-Pflücker, Salima Janmohamed, Patricia Benveniste, Meinrad Busslinger, Robert Herrington, Mary Barbara, Norman N. Iscove, Catherine Frelin, Gary Tran, Christopher J. Paige

Publikováno v: Nature immunology

The transcription factor GATA-3 is expressed and required for differentiation and function throughout the T lymphocyte lineage. Despite evidence it may also be expressed in multipotent hematopoietic stem cells (HSCs), any role for GATA-3 in these cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9044de3a1452fdd43891e706ac6a7b8d
http://europepmc.org/articles/PMC4972578

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