Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Norman L. Colbry"'
Autor:
Anne Akin, Jacob Bradley Schwarz, Johnson Paul D, Peter G. Blazecka, Osuma Augustine Tobi, Derek Vrieze, Mark S. Plummer, Yun Huang, Ji Zhang, Michael Lovdahl, Norman L. Colbry, Brian Samas, Joseph Richard Bozelak, Timothy T. Curran, Andrew John Thorpe, Derek A. Pflum, Annise Paige Goodman, David C. Boyles, Garrett Hoge, Suzanne Ross Kesten
Publikováno v:
Tetrahedron Letters. 50:1167-1170
A chiral β-amino acid containing three contiguous chiral centers was synthesized efficiently in 11 steps, employing enantio-enriched β-ketoester as a key intermediate, via stereoselective catalytic hydrogenation of the corresponding enamide. Stereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d77d1706191e8bace6d13ac9ba860e5
https://doi.org/10.1016/j.tetlet.2008.12.111
https://doi.org/10.1016/j.tetlet.2008.12.111
Publikováno v:
Organic Process Research & Development. 12:884-887
Linezolid, compound 1, is a member of the oxazolidinone class of antibacterials and has had recent clinical interest due to its potential use as a long-term treatment for bacterial infection. Detailed herein are improvements to the original synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ec472811de3492786e627b3015eaae1
https://doi.org/10.1021/op8001195
https://doi.org/10.1021/op8001195
Autor:
Brian Nichelson, Mark G. Vartanian, Charles Taylor, Susan M. Lotarski, Nancy Sue Barta, Sean D. Donevan, Sian E. Gibbons, Norman L. Colbry, Zhu Zhijian, Melvin R. Dickerson, Paul Galatsis, Russell J. DeOrazio, Jacob Bradley Schwarz, Kristin Knapp Lin, Zheng Li, Andrew John Thorpe, Jack J. Kinsora, Raymond Andrew Hudack, David J. Wustrow, David D. Manning, Ayman El-Kattan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3559-3563
Several beta-amino tetrazole analogs of gabapentin 1 and pregabalin 2 were prepared by one of two convergent, highly efficient routes, and their affinity for the alpha(2)-delta protein examined. Two select compounds with potent affinity for alpha(2)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71639ec10a452e24f369e2dc36c1c1f
https://doi.org/10.1016/j.bmcl.2006.03.083
https://doi.org/10.1016/j.bmcl.2006.03.083
Publikováno v:
Tetrahedron Letters. 46:2087-2091
For the purpose of drug interaction studies, the stable-isotope labeled [ 13 C 3 ]midazolam and its metabolite, 1′-hydroxy-[ 13 C 3 ]midazolam were synthesized in four and five steps in overall yields of 25.5% and 14.2%, from 7-chloro-5-(2-fluoroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c3ff17e6f43817d4f1661ebab013a1d
https://doi.org/10.1016/j.tetlet.2005.01.128
https://doi.org/10.1016/j.tetlet.2005.01.128
Autor:
David Juergen Wustrow, Thomas G. Heffner, Michael Duff Davis, Lynn M. Georgic, Suzanne Ross Kesten, Anthony C. Blackburn, Ronald Rubin, Thomas Richard Belliotti, Shelly Ann Glase, Ann E. Corbin, Hyacinth Akunne, T. A. Pugsley, Norman L. Colbry, Steven Z. Whetzel, Kim Zoski, Lawrence D. Wise, D. R. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 41:760-771
A series of [4-[2(4-arylpiperazin-1-yl)alkyl]cyclohexyl]pyrimidin-2-ylamine s was prepared and found to have receptor binding affinity for D2 and D3 dopamine (DA) receptors and serotonin 5-HT1A receptors. The structural contributions to D2/D3 and 5-H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a87db13947cb7fb22fb6f9cfb72e85f
https://doi.org/10.1021/jm9707378
https://doi.org/10.1021/jm9707378
Autor:
Alan Daugherty, Kathryn Welch, Richard D. Dyer, Joseph A. Cornicelli, Thomas M.A. Bocan, Sandra M. Sendobry, Bharat K. Trivedi, Steven J. Feinmark, Norman L. Colbry, Bradley Dean Tait
Publikováno v:
British Journal of Pharmacology. 120:1199-1206
1. 15-Lipoxygenase (15-LO) has been implicated in the pathogenesis of atherosclerosis because of its localization in lesions and the many biological activities exhibited by its products. To provide further evidence for a role of 15-LO, the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49b353f7ba83d34ec9185125120a866f
https://doi.org/10.1038/sj.bjp.0701007
https://doi.org/10.1038/sj.bjp.0701007
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50c218e5482aea4b5556808dcb38c110
https://doi.org/10.1002/chin.199129260
https://doi.org/10.1002/chin.199129260
Autor:
Vladimir Genukh Beylin, Susan E. Uhlendorf, Donald R. Johnson, Norman L. Colbry, H. D. Hollis Showalter, Edward P. Lewis, Boguslawa Leja, A. D. Sercel, Michael D. Reily, David M. Lustgarten, Peter Mcdonnell, Robert L. Leeds, O. P. Goel, Anne B. Giordani, Katherine A. Zisek
Publikováno v:
Journal of Heterocyclic Chemistry. 28:517-527
Improved processes for the synthesis of bulk quantities of the benzothiopyranoindazole clinical agent CI-958 and A-ring congeners is reported. The process chosen for scale-up operations achieves β-aminoethylation of an anilino precursor via a three-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3eb30e61e80a90addf7c6b038738e64
https://doi.org/10.1002/jhet.5570280261
https://doi.org/10.1002/jhet.5570280261
Publikováno v:
Journal of Heterocyclic Chemistry. 28:97-108
New derivatives of the naturally occurring amino acid 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid (spinacine) are reported. These include amide, ester, 5-alkyl and acyl, and regiospecific N im -alkyl and aralkyl derivatives. Synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d88bbea9be45309663af9e4dc36cc1f5
https://doi.org/10.1002/jhet.5570280118
https://doi.org/10.1002/jhet.5570280118
Autor:
Susan M. Lotarski, David J. Wustrow, Melvin R. Dickerson, Norman L. Colbry, Mark L. Weber, Shelley Rene Graham, Sian E. Gibbons, Ti-Zhi Su, Schwarz Jacob Bradley, Jack J. Kinsora, Ayman El-Kattan, Mark G. Vartanian, Andrew J. Thorpe, Van-Duc Le, Peter R. Guzzo, Charles Price Taylor, Sean D. Donevan, Zheng Li
Publikováno v:
Journal of medicinal chemistry. 48(8)
As part of a program aimed at generating compounds with affinity for the alpha(2)-delta subunit of voltage-gated calcium channels, several novel beta-amino acids were prepared using an efficient nitroalkane-mediated cyclopropanation as a key step. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16b56d1bccad3bb7ecbbe1836620fa4
https://pubmed.ncbi.nlm.nih.gov/15828841
https://pubmed.ncbi.nlm.nih.gov/15828841