Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Norman J. Haughey"'
Autor:
Joseph Choi, Danielle M. Smith, Ye Jin Lee, Danfeng Cai, Mohammad J. Hossain, Tamara J. O’Connor, Pragney Deme, Norman J. Haughey, Susanna Scafidi, Ryan C. Riddle, Michael J. Wolfgang
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110642- (2024)
Summary: Etomoxir has been used for decades as a popular small molecule inhibitor of carnitine palmitoyltransferase I, Cpt1, to block mitochondrial fatty acid β-oxidation. To test the specificity of etomoxir, we generated click chemistry–enabled r
Externí odkaz:
https://doaj.org/article/937993dcfc3540bfb41e12efc0dd8eca
Autor:
Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R. Joe, Rana Rais, Norman J. Haughey, Dimitrios Kapogiannis, Barbara S. Slusher
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-20 (2023)
Abstract Background Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is trigge
Externí odkaz:
https://doaj.org/article/d163368f208644598366636e9b045806
Autor:
Joshua A. Welsh, Deborah C. I. Goberdhan, Lorraine O'Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Juan M. Falcon‐Perez, Qing‐Ling Fu, Andrew F. Hill, Metka Lenassi, Sai Kiang Lim, Mỹ G. Mahoney, Sujata Mohanty, Andreas Möller, Rienk Nieuwland, Takahiro Ochiya, Susmita Sahoo, Ana C. Torrecilhas, Lei Zheng, Andries Zijlstra, Sarah Abuelreich, Reem Bagabas, Paolo Bergese, Esther M. Bridges, Marco Brucale, Dylan Burger, Randy P. Carney, Emanuele Cocucci, Rossella Crescitelli, Edveena Hanser, Adrian L. Harris, Norman J. Haughey, An Hendrix, Alexander R. Ivanov, Tijana Jovanovic‐Talisman, Nicole A. Kruh‐Garcia, Vroniqa Ku'ulei‐Lyn Faustino, Diego Kyburz, Cecilia Lässer, Kathleen M. Lennon, Jan Lötvall, Adam L. Maddox, Elena S. Martens‐Uzunova, Rachel R. Mizenko, Lauren A. Newman, Andrea Ridolfi, Eva Rohde, Tatu Rojalin, Andrew Rowland, Andras Saftics, Ursula S. Sandau, Julie A. Saugstad, Faezeh Shekari, Simon Swift, Dmitry Ter‐Ovanesyan, Juan P. Tosar, Zivile Useckaite, Francesco Valle, Zoltan Varga, Edwin van derPol, Martijn J. C. vanHerwijnen, Marca H. M. Wauben, Ann M. Wehman, Sarah Williams, Andrea Zendrini, Alan J. Zimmerman, MISEV Consortium, Clotilde Théry, Kenneth W. Witwer
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 2, Pp n/a-n/a (2024)
Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have gene
Externí odkaz:
https://doaj.org/article/62d9f58d0f2b47e292d51b7893a73080
Autor:
Sehmus Tohumeken, Pragney Deme, Seung Wan Yoo, Sujasha Gupta, Rana Rais, Barbara S. Slusher, Norman J. Haughey
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 105987- (2023)
Extracellular vesicles (EVs) have been proposed to regulate the deposition of Aβ. Multiple publications have shown that APP, amyloid processing enzymes and Aβ peptides are associated with EVs. However, very little Aβ is associated with EVs compare
Externí odkaz:
https://doaj.org/article/9466fab8fdb04fdba31a3bc294aee098
Autor:
Xiaolei Zhu, Kristen R. Hollinger, Yiyao Huang, Alejandra Borjabad, Boe-Hyun Kim, Tanina Arab, Ajit G. Thomas, Mohammed Moniruzzaman, Lyndah Lovell, Andrey Turchinovich, Kenneth W. Witwer, David J. Volsky, Norman J. Haughey, Barbara S. Slusher
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105734- (2022)
People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population. The enzyme neutral sphingomyelinase 2 (nSMase2) is involved in the biogenesis of ceramide and
Externí odkaz:
https://doaj.org/article/dafd878bacf3408985cbb67f41a0b5db
Autor:
Carolyn Tallon, Benjamin J. Bell, Anjali Sharma, Arindom Pal, Medhinee M. Malvankar, Ajit G. Thomas, Seung-Wan Yoo, Kristen R. Hollinger, Kaleem Coleman, Elizabeth L. Wilkinson, Sujatha Kannan, Norman J. Haughey, Rangaramanujam M. Kannan, Rana Rais, Barbara S. Slusher
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2066 (2022)
Alzheimer’s disease (AD) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (pTau), which can spread throughout the brain via extracellular vesicles (EVs). Membrane ceramide enrichment regulated by the enzyme
Externí odkaz:
https://doaj.org/article/5393689d5ecd4b8598d99f7d3e2fafda
Autor:
Pragney Deme, Leah H. Rubin, Danyang Yu, Yanxun Xu, Gertrude Nakigozi, Noeline Nakasujja, Aggrey Anok, Alice Kisakye, Thomas C. Quinn, Steven J. Reynolds, Richard Mayanja, James Batte, Maria J. Wawer, Ned C. Sacktor, Deanna Saylor, Norman J. Haughey
Publikováno v:
Viruses, Vol 14, Iss 6, p 1313 (2022)
Background: HIV infection results in immunometabolic reprogramming. While we are beginning to understand how this metabolic reprogramming regulates the immune response to HIV infection, we do not currently understand the impact of ART on immunometabo
Externí odkaz:
https://doaj.org/article/e74935357eb9489580bd18522080a402
Autor:
Tanina Arab, Emily R. Mallick, Yiyao Huang, Liang Dong, Zhaohao Liao, Zezhou Zhao, Olesia Gololobova, Barbara Smith, Norman J. Haughey, Kenneth J. Pienta, Barbara S. Slusher, Patrick M. Tarwater, Juan Pablo Tosar, Angela M. Zivkovic, Wyatt N. Vreeland, Michael E. Paulaitis, Kenneth W. Witwer
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract We compared four orthogonal technologies for sizing, counting, and phenotyping of extracellular vesicles (EVs) and synthetic particles. The platforms were: single‐particle interferometric reflectance imaging sensing (SP‐IRIS) with fluore
Externí odkaz:
https://doaj.org/article/fd746bab0cb349b79fa923c7436a96ca
Autor:
Raha M. Dastgheyb, Alison S. Buchholz, Kathryn C. Fitzgerald, Yanxun Xu, Dionna W. Williams, Gayle Springer, Kathryn Anastos, Deborah R. Gustafson, Amanda B. Spence, Adaora A. Adimora, Drenna Waldrop, David E. Vance, Joel Milam, Hector Bolivar, Kathleen M. Weber, Norman J. Haughey, Pauline M. Maki, Leah H. Rubin
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Cognitive impairment remains frequent and heterogeneous in presentation and severity among virally suppressed (VS) women with HIV (WWH). We identified cognitive profiles among 929 VS-WWH and 717 HIV-uninfected women from 11 Women's Interagency HIV St
Externí odkaz:
https://doaj.org/article/838402b711b6400a97c8f66affa763ff
Autor:
Yiyao Huang, Lesley Cheng, Andrey Turchinovich, Vasiliki Mahairaki, Juan C. Troncoso, Olga Pletniková, Norman J. Haughey, Laura J. Vella, Andrew F. Hill, Lei Zheng, Kenneth W. Witwer
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Extracellular vesicles (EVs) are involved in a wide range of physiological and pathological processes by shuttling material out of and between cells. Tissue EVs may thus lend insights into disease mechanisms and also betray disease when released into
Externí odkaz:
https://doaj.org/article/02d0cae4c1d8448dbb45f81a76c7ede8