Zobrazeno 1 - 10 of 258 pro vyhledávání: '"Norman J Maitland"'
1
Akademický článek
Evaluating baculovirus as a vector for human prostate cancer gene therapy.
Autor: Stephanie L Swift, Guillermo C Rivera, Vincent Dussupt, Regina M Leadley, Lucy C Hudson, Corrina Ma de Ridder, Robert Kraaij, Julie E Burns, Norman J Maitland, Lindsay J Georgopoulos
Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65557 (2013)
Gene therapy represents an attractive strategy for the non-invasive treatment of prostate cancer, where current clinical interventions show limited efficacy. Here, we evaluate the use of the insect virus, baculovirus (BV), as a novel vector for human
Externí odkaz: https://doaj.org/article/2b44e3f412824eb893a9ff1215f03de6
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2
Akademický článek
Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells.
Autor: Engin Ulukaya, Fiona M Frame, Buse Cevatemre, Davide Pellacani, Hannah Walker, Vincent M Mann, Matthew S Simms, Michael J Stower, Veysel T Yilmaz, Norman J Maitland
Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64278 (2013)
The outcome for patients with advanced metastatic and recurrent prostate cancer is still poor. Therefore, new chemotherapeutics are required, especially for killing cancer stem cells that are thought to be responsible for disease recurrence. In this
Externí odkaz: https://doaj.org/article/fa2ab04b61094a7daa200d16cc8d7ccd
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3
Akademický článek
The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates
Autor: Claudia Buhigas, Anne Y. Warren, Wing-Kit Leung, Hayley C. Whitaker, Hayley J. Luxton, Steve Hawkins, Jonathan Kay, Adam Butler, Yaobo Xu, Dan J. Woodcock, Sue Merson, Fiona M. Frame, Atef Sahli, Federico Abascal, CRUK-ICGC Prostate Cancer Group, Iñigo Martincorena, G. Steven Bova, Christopher S. Foster, Peter Campbell, Norman J. Maitland, David E. Neal, Charlie E. Massie, Andy G. Lynch, Rosalind A. Eeles, Colin S. Cooper, David C. Wedge, Daniel S. Brewer
Publikováno v: Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied W
Externí odkaz: https://doaj.org/article/ab88a2ce376d486096a3008701e9592f
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4
Akademický článek
ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate
Autor: Leanne K. Archer, Fiona M. Frame, Hannah F. Walker, Alastair P. Droop, Georgina L. K. McDonald, Samuel Kucko, Daniel M. Berney, Vincent M. Mann, Matthew S. Simms, Norman J. Maitland
Publikováno v: FEBS Open Bio, Vol 12, Iss 7, Pp 1365-1387 (2022)
This study aimed to elucidate the role of ELF3, an ETS family member in normal prostate growth and prostate cancer. Silencing ELF3 in both benign prostate (BPH‐1) and prostate cancer (PC3) cell lines resulted in decreased colony‐forming ability,
Externí odkaz: https://doaj.org/article/aa77d4e3bca64e6fbadf19f5700541d1
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6
Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer
Autor: Ali I. M. Ibrahim, Elisabet Batlle, Smarakan Sneha, Rafael Jiménez, Raquel Pequerul, Xavier Parés, Till Rüngeler, Vibhu Jha, Tiziano Tuccinardi, Maria Sadiq, Fiona Frame, Norman J. Maitland, Jaume Farrés, Klaus Pors
Publikováno v: Journal of Medicinal Chemistry. 65:3833-3848
Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer and considered a potential target for therapeutic intervention. 4-(Diethylamino)benzaldehyde (DEAB) has been extensively reported as a pan-inhibitor of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afaeea21d5090735ad972cdce93e8fa
https://doi.org/10.1021/acs.jmedchem.1c01367
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