Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Norman J Haughey"'
Autor:
J Eduardo Rico, Sina Saed Samii, Alice T Mathews, Jacqueline Lovett, Norman J Haughey, Joseph W McFadden
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176787 (2017)
Reduced insulin action develops naturally during the peripartum to ensure maternal nutrient delivery to the fetus and neonate. However, increased insulin resistance can facilitate excessive lipolysis which in turn promotes metabolic disease in overwe
Externí odkaz:
https://doaj.org/article/042cf984492b477cbdd0bd73f88fa91a
Autor:
Michael S Piepenbrink, Memorie Samuel, Bo Zheng, Brittany Carter, Christopher Fucile, Catherine Bunce, Michelle Kiebala, Atif A Khan, Juilee Thakar, Sanjay B Maggirwar, Diane Morse, Alexander F Rosenberg, Norman J Haughey, William Valenti, Michael C Keefer, James J Kobie
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158641 (2016)
Injection drug use is a growing major public health concern. Injection drug users (IDUs) have a higher incidence of co-morbidities including HIV, Hepatitis, and other infections. An effective humoral response is critical for optimal homeostasis and p
Externí odkaz:
https://doaj.org/article/3df7b2ff0e9f4b809c0c9be0c9335168
Autor:
Mariana Figuera-Losada, Marigo Stathis, Joelle M Dorskind, Ajit G Thomas, Veera Venkata Ratnam Bandaru, Seung-Wan Yoo, Nicholas J Westwood, Graeme W Rogers, Justin C McArthur, Norman J Haughey, Barbara S Slusher, Camilo Rojas
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124481 (2015)
Ceramide is a bioactive lipid that plays an important role in stress responses leading to apoptosis, cell growth arrest and differentiation. Ceramide production is due in part to sphingomyelin hydrolysis by sphingomyelinases. In brain, neutral sphing
Externí odkaz:
https://doaj.org/article/222fdc4e88944241b91dbd2b6007f107
Autor:
Joseph W McFadden, Susan Aja, Qun Li, Veera V R Bandaru, Eun-Kyoung Kim, Norman J Haughey, Francis P Kuhajda, Gabriele V Ronnett
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115642 (2014)
Modification of hypothalamic fatty acid (FA) metabolism can improve energy homeostasis and prevent hyperphagia and excessive weight gain in diet-induced obesity (DIO) from a diet high in saturated fatty acids. We have shown previously that C75, a sti
Externí odkaz:
https://doaj.org/article/53736a7662d34e2aaa4b3122d532c78e
Autor:
Subroto Chatterjee, Nezar Alsaeedi, Jennifer Hou, Veera Venkata Ratnam Bandaru, Lan Wu, Marc K Halushka, Roberto Pili, Georges Ndikuyeze, Norman J Haughey
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63726 (2013)
In a xenograft model wherein, live renal cancer cells were implanted under the kidney capsule in mice, revealed a 30-fold increase in tumor volume over a period of 26 days and this was accompanied with a 32-fold increase in the level of lactosylceram
Externí odkaz:
https://doaj.org/article/57d8c0665a9c4073b4e5fa2fe80c1ac4
Autor:
Michelle M Mielke, Walter Maetzler, Norman J Haughey, Veera V R Bandaru, Rodolfo Savica, Christian Deuschle, Thomas Gasser, Ann-Kathrin Hauser, Susanne Gräber-Sultan, Erwin Schleicher, Daniela Berg, Inga Liepelt-Scarfone
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73094 (2013)
Mutations in the gene coding for glucocerebrosidase (GBA), which metabolizes glucosylceramide (a monohexosylceramide) into glucose and ceramide, is the most common genetic risk factor for sporadic Parkinson's disease (PD). GBA mutation carriers are m
Externí odkaz:
https://doaj.org/article/a5a6e48cd197436e9acecf61d54114ee
Autor:
Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R. Joe, Rana Rais, Norman J. Haughey, Dimitrios Kapogiannis, Barbara S. Slusher
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-20 (2023)
Abstract Background Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is trigge
Externí odkaz:
https://doaj.org/article/d163368f208644598366636e9b045806
Publikováno v:
ASN Neuro, Vol 4 (2012)
Combined anti-retroviral therapeutic drugs effectively increase the lifespan of HIV-1-infected individuals who then have a higher prevalence of HAND (HIV-1 associated neurocognitive disorder). Soluble factors including HIV-1 proteins released from HI
Externí odkaz:
https://doaj.org/article/16e44d9635574a37bcc87c34671339cc
Autor:
Gijs eKooij, Jack evan Horssen, Veera Venkata Ratnam eBandaru, Norman J Haughey, Helga E De Vries
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
ATP-binding cassette (ABC) transporters are highly expressed by brain endothelial cells that form the blood-brain barrier (BBB). These efflux pumps play an important role in maintaining brain homeostasis as they actively hinder the entry of unwanted
Externí odkaz:
https://doaj.org/article/3d5308482a5a49c0a8d284ceb68ec967
Autor:
Bao Lige, Julia D Romano, Veera Venkata Ratnam Bandaru, Karen Ehrenman, Jelena Levitskaya, Vera Sampels, Norman J Haughey, Isabelle Coppens
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002410 (2011)
Several proteins that play key roles in cholesterol synthesis, regulation, trafficking and signaling are united by sharing the phylogenetically conserved 'sterol-sensing domain' (SSD). The intracellular parasite Toxoplasma possesses at least one gene
Externí odkaz:
https://doaj.org/article/ac1e6e400e7c4cfab79bfdbe589db834