Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Norman H. Dyson"'
Hydrogenation of a Chiral 1H-Benz[de]isoquinolin-1-one and an Equilibration Using Palladium Catalyst
Publikováno v:
Organic Process Research & Development. 1:117-120
The catalytic hydrogenation of a chiral 1H-benz[de]isoquinolin-1-one to palonosetron and the undesired diastereomer was optimized using a variety of conditions and catalysts. The most selective catalyst for the production of palonosetron was an unred
Autor:
Thomas V. Alfredson, Bruce Griffin, Robert Towne, Denis J. Kertesz, Allassan Abubakari, Norman H. Dyson, Michelle Elliott
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 19:1653-1668
Separation of the stereoisomers of azalanstat (RS-21607-197), a substituted imidazolyl-1,3-dioxolane which acts as a potent inhibitor of lanosterol 14α-demethylase in cholesterol biosynthesis, and its ketal tosylate intermediate was achieved by chir