Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Norman H. Altman"'
Autor:
Jacqueline A. Wright, Cassandra Bazile, Emily S. Clark, Gianluca Carlesso, Justin Boucher, Eden Kleiman, Tamer Mahmoud, Lily I. Cheng, Darlah M. López-Rodríguez, Anne B. Satterthwaite, Norman H. Altman, Eric L. Greidinger, Wasif N. Khan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
While apoptosis plays a role in B-cell self-tolerance, its significance in preventing autoimmunity remains unclear. Here, we report that dysregulated B cell apoptosis leads to delayed onset autoimmune phenotype in mice. Our longitudinal studies revea
Externí odkaz:
https://doaj.org/article/eab5bbc02d4a4b57baacd503e0b3f214
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Interleukin-2 (IL-2) signaling is required for regulatory T (Treg) cell differentiation in the thymus, but its function in peripheral Tregs is still unclear. Here the authors show, using inducible deletion of IL-2 receptor subunit CD25, that IL-2 sig
Externí odkaz:
https://doaj.org/article/edffae69c74843b0943c3bedba105ea2
Autor:
Carolyn Cray, Norman H Altman
Publikováno v:
Comp Med
Fenbendazole remains the drug of choice to treat pinworm infection in laboratory rodents. When fenbendazole was last reviewed (15 y ago), the literature supported the drug's lack of toxic effects at therapeutic levels, yet various demonstrated physio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aeff87bccdb928dd627c35e14b7d130
https://pubmed.ncbi.nlm.nih.gov/35764389
https://pubmed.ncbi.nlm.nih.gov/35764389
Autor:
Andrew V. Schally, Chongxu Zhang, Aaron Lazerson, Greg Holt, Michael Campos, Robert M. Jackson, Mehdi Mirsaeidi, Norman H. Altman, Stephanie Chery
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Lung inflammation due to sarcoidosis is characterized by a complex cascade of immunopathologic events, including leukocyte recruitment and granuloma formation. α-melanocyte stimulating hormone (α-MSH) is a melanocortin signaling peptide with anti-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391501d6bb9af7f8ad21b03300f74594
http://link.springer.com/article/10.1038/s41598-020-64305-9
http://link.springer.com/article/10.1038/s41598-020-64305-9
Autor:
Darlah M. López-Rodríguez, Justin Boucher, Eden Kleiman, Emily S. Clark, Eric L. Greidinger, Norman H. Altman, Jacqueline A. Wright, Anne B. Satterthwaite, Tamer Mahmoud, Lily Cheng, Gianluca Carlesso, Wasif N. Khan, Cassandra Bazile
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
While apoptosis plays a role in B-cell self-tolerance, its significance in preventing autoimmunity remains unclear. Here, we report that dysregulated B cell apoptosis leads to delayed onset autoimmune phenotype in mice. Our longitudinal studies revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3833979e0a35ab6e4226b6eb152115cc
https://www.frontiersin.org/articles/10.3389/fimmu.2021.705307/full
https://www.frontiersin.org/articles/10.3389/fimmu.2021.705307/full
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
IL-2R signaling is essential for regulatory T cell (Treg) function. However, the precise contribution of IL-2 during Treg thymic development, peripheral homeostasis and lineage stability remains unclear. Here we show that IL-2R signaling is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd6c0689b6f9c923456a11a80270f8a
https://doaj.org/article/edffae69c74843b0943c3bedba105ea2
https://doaj.org/article/edffae69c74843b0943c3bedba105ea2
Autor:
Dietlinde Wolf, Krishna V. Komanduri, Brandon Kale, Sabrina Copsel, Cameron S. Bader, Casey O. Lightbourn, Warren Alperstein, Henry Barreras, Robert B. Levy, Norman H. Altman
Publikováno v:
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, vol 24, iss 9
Regulatory T cells (Tregs) are essential for the maintenance of tolerance and immune homeostasis. In allogeneic hematopoietic stem cell transplantation (aHSCT), transfer of appropriate Treg numbers is a promising therapy for the prevention of graft-v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef4fc58213e1f106150024b351653b6
https://doi.org/10.1016/j.bbmt.2018.04.026
https://doi.org/10.1016/j.bbmt.2018.04.026
The Lower Limit of Regulatory CD4+ Foxp3+ TCRβ Repertoire Diversity Required To Control Autoimmunity
Publikováno v:
The Journal of Immunology. 198:3127-3135
The TCR repertoire of regulatory T cells (Tregs) is highly diverse. The relevance of this diversity to maintain self-tolerance remains unknown. We established a model where the TCR repertoire of normal polyclonal Tregs was limited by serial transfers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc53c5b4b6cda1c56b91229ed3f575e
https://doi.org/10.4049/jimmunol.1601966
https://doi.org/10.4049/jimmunol.1601966
Autor:
C. Zhang, R.M. Jackson, R. Tian, Gregory E. Holt, Mehdi Mirsaeidi, Norman H. Altman, K.R. Schesser
Publikováno v:
A101. TRANSLATIONAL STUDIES IN ILD, IPF, AND SARCOIDOSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43ed1dc948501772ce0a939bb0ed6c5f
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2428
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2428
Autor:
K.R. Schesser, C. Zhang, R.M. Jackson, Gregory E. Holt, Norman H. Altman, Mehdi Mirsaeidi, Andrew V. Schally
Publikováno v:
C31. TRANSLATIONAL STUDIES IN SARCOIDOSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e3249fa30ff6711865ab55b913022a
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4506
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4506