Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Norman F. Sheppard"'
Publikováno v:
Biotechnology and Bioengineering. 75:475-484
In this article, we describe the use of pH- responsive hydrogels as matrices for the immobilization of two enzymes, glucose oxidase (GOx) and glutamate oxidase (GlutOx). Spherical hydrogel beads were prepared by inverse suspension polymerization and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba651c2a64b68af2ef482c03d8c42e5
https://doi.org/10.1002/bit.10069
https://doi.org/10.1002/bit.10069
Publikováno v:
Analytical Chemistry. 71:4669-4678
This paper describes a microfluidic system in which fluids are pumped by centrifugal force through microscopic channels defined in a plastic disk in order to perform complex analytical processes. The channels are created either by casting poly(dimeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb42ecd48aced48135543f40cf070806
https://doi.org/10.1021/ac990682c
https://doi.org/10.1021/ac990682c
Autor:
Norman F. Sheppard, Matthew J. Lesho
Publikováno v:
Polymer Gels and Networks. 5:503-523
A novel method was applied to the study of swelling kinetics of pH-responsive hydrogels. This technique is based on the pH-dependent electrical conductivity of these materials, which is measured by coating planar interdigitated electrode arrays with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76513053f204e188d250e2c420011d6a
https://doi.org/10.1016/s0966-7822(97)00024-5
https://doi.org/10.1016/s0966-7822(97)00024-5
Autor:
Asaf Keller, Lee A. Zimmer, Sergey Yagodin, Vassiliki Aroniadou-Anderjaska, Norman F. Sheppard, Michael T. Shipley, Matthew Ennis
Publikováno v:
The Journal of Neuroscience. 18:2602-2612
The functional organization and synaptic physiology of olfactory bulb glomeruli were studied in ratin vitroslice preparations stained with the voltage-sensitive dye RH-155. Optical signals were recorded with a 100-element photodiode array at high tem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0fa957ad515536f0fc71d3a0dc0b94
https://doi.org/10.1523/jneurosci.18-07-02602.1998
https://doi.org/10.1523/jneurosci.18-07-02602.1998
Autor:
Norman F. Sheppard, Matthew J. Lesho
Publikováno v:
Sensors and Actuators B: Chemical. 37:61-66
The use of a silane coupling agent, γ-methacryloxypropyl trimethoxysilane (γ-MPS), to promote adhesion of photolithographically patterned polymer hydrogels to oxidized silicon wafers and conductometric sensors has been examined. Poly-(hydroxyethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f83fdbfa05447931074532c372e73317
https://doi.org/10.1016/s0925-4005(97)80072-x
https://doi.org/10.1016/s0925-4005(97)80072-x
Publikováno v:
Journal of Controlled Release. 42:15-24
Physical models of polymer matrix controlled release systems were constructed by using silicon micromachining to fabricate miniature pore networks having features comparable in size to those found in the polymer systems. The networks were formed from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b156abde67715900df2ee56b976a1b7e
https://doi.org/10.1016/0168-3659(96)01337-5
https://doi.org/10.1016/0168-3659(96)01337-5
Publikováno v:
Biosensors and Bioelectronics. 11:967-979
A model for predicting the response of a conductimetric urea biosensor was developed and validated experimentally. The biosensor under consideration is formed by immobilizing the enzyme urease onto the surface of a planar interdigitated electrode arr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aee0f369b5a78023f527a65bdf62bb4
https://doi.org/10.1016/0956-5663(96)87656-1
https://doi.org/10.1016/0956-5663(96)87656-1
Publikováno v:
Sensors and Actuators B: Chemical. 28:95-102
A miniature conductimetric pH sensor has been developed, based on the measurement of the conductivity of a pH-responsive hydrogel. The microfabricated sensor is constructed by coating planar interdigitated electrode arrays with a photolithographicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fef54357a3c1e69ea96caedff1b5ee1
https://doi.org/10.1016/0925-4005(94)01542-p
https://doi.org/10.1016/0925-4005(94)01542-p
Autor:
Laura McCabe, Michael J. Cima, John T. Santini, James M. Anderson, Norman F. Sheppard, Robert Langer, Robert Farra, Robert M. Neer
Publikováno v:
Science Translational Medicine. 4
The first clinical trial of an implantable microchip-based drug delivery device is discussed. Human parathyroid hormone fragment (1-34) [hPTH(1-34)] was delivered from the device in vivo. hPTH(1-34) is the only approved anabolic osteoporosis treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63fb46f3500b36ee67065ac9e12c7ed
https://doi.org/10.1126/scitranslmed.3003276
https://doi.org/10.1126/scitranslmed.3003276
Autor:
Richard B. Dause, W. Mark Saltzman, J. Alan Pratt, Amy M. Dodrill, Norman F. Sheppard, Mark A. McHugh
Publikováno v:
Journal of Applied Polymer Science. 48:1493-1500
A new method is presented for controlling the rate of antibody (Ab) release from an inert matrix composed of poly(ethylene-co-vinyl acetate) (EVAc), a biocompatible polymer that is frequently used to achieve controlled release. Using supercritical pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96790745266f572c5fe281092e9266ec
https://doi.org/10.1002/app.1993.070480818
https://doi.org/10.1002/app.1993.070480818