Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Norman F. Kirkby"'
Autor:
Samuel P. Ingram, John-William Warmenhoven, Nicholas T. Henthorn, Amy L. Chadiwck, Elham E. Santina, Stephen J. McMahon, Jan Schuemann, Norman F. Kirkby, Ranald I. Mackay, Karen J. Kirkby, Michael J. Merchant
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
PyFoci is a tool that simulates distributions of fluorescently labeled DNA double-strand break marker protein foci and allows the estimation of miscounting under different radiation types, doses and microscopy settings.
Externí odkaz:
https://doaj.org/article/12f2d24396fc42b6b08bfd133060527c
Autor:
Bethany C. Rothwell, Matthew Lowe, Norman F. Kirkby, Michael J. Merchant, Amy L. Chadwick, Ranald I. Mackay, Jolyon H. Hendry, Karen J. Kirkby
Publikováno v:
Radiation, Vol 1, Iss 4, Pp 290-304 (2021)
FLASH radiotherapy is a rapidly developing field which promises improved normal tissue protection compared to conventional irradiation and no compromise on tumour control. The transient hypoxic state induced by the depletion of oxygen at high dose ra
Externí odkaz:
https://doaj.org/article/afdfad777b8f45178f2f1629ab81806f
Autor:
Charlotte J Heaven, Hannah C Wanstall, Nicholas T Henthorn, John-William Warmenhoven, Samuel P Ingram, Amy L Chadwick, Elham Santina, Jamie Honeychurch, Christine K Schmidt, Karen J Kirkby, Norman F Kirkby, Neil G Burnet, Michael J Merchant
Publikováno v:
Heaven, C J, Wanstall, H C, Henthorn, N T, Warmenhoven, J-W, Ingram, S P, Chadwick, A L, Santina, E, Honeychurch, J, Schmidt, C K, Kirkby, K J, Kirkby, N F, Burnet, N G & Merchant, M J 2022, ' The suitability of micronuclei as markers of relative biological effect ', Mutagenesis, vol. 37, no. 1, pp. 3-12 . https://doi.org/10.1093/mutage/geac001
Mutagenesis
Mutagenesis
Micronucleus (MN) formation is routinely used as a biodosimeter for radiation exposures and has historically been used as a measure of DNA damage in cells. Strongly correlating with dose, MN are also suggested to indicate radiation quality, different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49bf05d1313e5ad799a37f6ed467a7d
https://doi.org/10.1093/mutage/geac001
https://doi.org/10.1093/mutage/geac001
Autor:
Karen J. Kirkby, Ranald I Mackay, Matthew Lowe, Bethany C Rothwell, Jolyon H Hendry, Neil G. Burnet, Norman F. Kirkby
Publikováno v:
Radiotherapy and Oncology. 164:122-127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b8e9dccc0d1d25adf2ac98411656f7
https://doi.org/10.1016/j.radonc.2021.09.011
https://doi.org/10.1016/j.radonc.2021.09.011
Autor:
T. Mee, Karen J. Kirkby, Rajesh Jena, Alexander John Vickers, Ananya Choudhury, Norman F. Kirkby
Publikováno v:
Clinical Oncology (Royal College of Radiologists (Great Britain)
Aims Cancer incidence varies across England, which affects the local-level demand for treatments. The magnetic resonance-linac (MR-linac) is a new radiotherapy technology that combines imaging and treatment. Here we model the demand and demand variat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4722c32c38277d99dac977aa055c408
https://doi.org/10.1016/j.clon.2021.03.004
https://doi.org/10.1016/j.clon.2021.03.004
Autor:
Xue W. Mei, Tim Maughan, Maria A. Hawkins, T. Mee, Frank Van den Heuvel, David A. Jones, Alastair Gray, Karen J. Kirkby, Joel Smith, Norman F. Kirkby
Publikováno v:
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, Vol 20, Iss, Pp 19-26 (2020)
Clinical and Translational Radiation Oncology, Vol 20, Iss, Pp 19-26 (2020)
Highlights • The cost-effectiveness of PBT for adult cancers is subject to considerable uncertainty. • Cost-utility analysis is the gold standard for assessing value, but quality matters. • Our review found studies lacked external validation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888b4fce6ea4458179bbd94a7bf4641d
https://doi.org/10.1016/j.ctro.2019.10.007
https://doi.org/10.1016/j.ctro.2019.10.007
Autor:
Michael J. Merchant, Jolyon H Hendry, Matthew Lowe, Bethany C. Rothwell, Norman F. Kirkby, Ranald I Mackay, Amy L. Chadwick, Karen J. Kirkby
Publikováno v:
Radiation; Volume 1; Issue 4; Pages: 290-304
Rothwell, B, Lowe, M, Kirkby, N, Merchant, M, Chadwick, A, Mackay, R, Hendry, J & Kirkby, K 2021, ' Oxygen depletion in proton spot scanning: a tool for exploring the conditions needed for FLASH ', Radiation, vol. 1, no. 4, pp. 290-304 . https://doi.org/10.3390/radiation1040024
Radiation 2021
Radiation, Vol 1, Iss 24, Pp 290-304 (2021)
Rothwell, B, Lowe, M, Kirkby, N, Merchant, M, Chadwick, A, Mackay, R, Hendry, J & Kirkby, K 2021, ' Oxygen depletion in proton spot scanning: a tool for exploring the conditions needed for FLASH ', Radiation, vol. 1, no. 4, pp. 290-304 . https://doi.org/10.3390/radiation1040024
Radiation 2021
Radiation, Vol 1, Iss 24, Pp 290-304 (2021)
FLASH radiotherapy is a rapidly developing field which promises improved normal tissue protection compared to conventional irradiation and no compromise on tumour control. The transient hypoxic state induced by the depletion of oxygen at high dose ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e2ae443b30f2702875ec9bb8694df3
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83477 (2014)
Knowledge of how a population of cancerous cells progress through the cell cycle is vital if the population is to be treated effectively, as treatment outcome is dependent on the phase distributions of the population. Estimates on the phase distribut
Externí odkaz:
https://doaj.org/article/7319b14310024093beea4b4e4c406639
Autor:
Nicholas Henthorn, Michael J. Merchant, Karen J. Kirkby, Norman F. Kirkby, Samuel Ingram, Ranald I Mackay, J.W. Warmenhoven
Publikováno v:
PLoS Computational Biology
PLOS Computational Biology
Ingram, S P, Henthorn, N T, Warmenhoven, J W, Kirkby, N F, Mackay, R I, Kirkby, K J & Merchant, M J 2020, ' Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage ', PLoS computational biology, vol. 16, no. 12, e1008476 . https://doi.org/10.1371/journal.pcbi.1008476
PLoS Computational Biology, Vol 16, Iss 12, p e1008476 (2020)
PLOS Computational Biology
Ingram, S P, Henthorn, N T, Warmenhoven, J W, Kirkby, N F, Mackay, R I, Kirkby, K J & Merchant, M J 2020, ' Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage ', PLoS computational biology, vol. 16, no. 12, e1008476 . https://doi.org/10.1371/journal.pcbi.1008476
PLoS Computational Biology, Vol 16, Iss 12, p e1008476 (2020)
Developments in the genome organisation field has resulted in the recent methodology to infer spatial conformations of the genome directly from experimentally measured genome contacts (Hi-C data). This provides a detailed description of both intra- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dde9d0ab5f7e4b2af9f34fbd1d04c1
https://pubmed.ncbi.nlm.nih.gov/33326415
https://pubmed.ncbi.nlm.nih.gov/33326415
Autor:
Norman F. Kirkby, T S A Underwood, A. Aitkenhead, J.W. Warmenhoven, Amy L. Chadwick, Neil G. Burnet, Nicholas Henthorn, Karen J. Kirkby, J. C. Richardson, Peter Sitch, E. Smith, Ranald I Mackay, Michael J. Merchant, Samuel Ingram
Publikováno v:
Smith, E, Henthorn, N, Warmenhoven, J, Ingram, S, Aitkenhead, A, Richardson, J, Chadwick, A, Underwood, T, Merchant, M, Burnet, N, Kirkby, N, Kirkby, K & Mackay, R 2019, ' In Silico Models of DNA Damage and Repair in Proton Treatment Planning: A Proof of Concept ', Scientific Reports . https://doi.org/10.1038/s41598-019-56258-5
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
There is strong in vitro cell survival evidence that the relative biological effectiveness (RBE) of protons is variable, with dependence on factors such as linear energy transfer (LET) and dose. This is coupled with the growing in vivo evidence, from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5586cb83cdaa91493ae973acf63d270
https://doi.org/10.1038/s41598-019-56258-5
https://doi.org/10.1038/s41598-019-56258-5
