Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Norman E. Davey"'
Autor:
Changqing Li, Stefano Moro, Kateryna Shostak, Francis J. O’Reilly, Mariel Donzeau, Andrea Graziadei, Alastair G. McEwen, Dominique Desplancq, Pierre Poussin-Courmontagne, Thomas Bachelart, Mert Fiskin, Nicolas Berrodier, Simon Pichard, Karl Brillet, Georges Orfanoudakis, Arnaud Poterszman, Vladimir Torbeev, Juri Rappsilber, Norman E. Davey, Alain Chariot, Katia Zanier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The inhibitor of κB (IκB) kinase (IKK) is a central regulator of NF-κB signaling. All IKK complexes contain hetero- or homodimers of the catalytic IKKβ and/or IKKα subunits. Here, we identify a YDDΦxΦ motif, which is conserved in subs
Externí odkaz:
https://doaj.org/article/7002b32fa22e4bd38f05d9ec9d049537
Autor:
Filip Mihalič, Caroline Benz, Eszter Kassa, Richard Lindqvist, Leandro Simonetti, Raviteja Inturi, Hanna Aronsson, Eva Andersson, Celestine N. Chi, Norman E. Davey, Anna K. Överby, Per Jemth, Ylva Ivarsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The virus life cycle depends on host-virus protein-protein interactions, which often involve a disordered protein region binding to a folded protein domain. Here, we used proteomic peptide phage display (ProP-PD) to identify peptides from th
Externí odkaz:
https://doaj.org/article/0dc8318509ba40b4a7a4978a68d342a6
Autor:
Filip Mihalič, Leandro Simonetti, Girolamo Giudice, Marie Rubin Sander, Richard Lindqvist, Marie Berit Akpiroro Peters, Caroline Benz, Eszter Kassa, Dilip Badgujar, Raviteja Inturi, Muhammad Ali, Izabella Krystkowiak, Ahmed Sayadi, Eva Andersson, Hanna Aronsson, Ola Söderberg, Doreen Dobritzsch, Evangelia Petsalaki, Anna K. Överby, Per Jemth, Norman E. Davey, Ylva Ivarsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions. Studies of motif-mediated interactions therefore provide insight into virus-host dependencies, and reveal targets for therapeutic intervention. Here,
Externí odkaz:
https://doaj.org/article/e64e95cb96fe4ac196aaf0a9198064f8
Autor:
Marta Ripamonti, Andrea Lamarca, Norman E. Davey, Diletta Tonoli, Sara Surini, Ivan de Curtis
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Liprin-α1 interacts with and recruits B56γ-PP2A at the front of migrating breast cancer cells, to promote cell protrusion and motility.
Externí odkaz:
https://doaj.org/article/c2df7b65cfde4ad79274e863b6867e83
Autor:
Thomas Kruse, Caroline Benz, Dimitriya H. Garvanska, Richard Lindqvist, Filip Mihalic, Fabian Coscia, Raviteja Inturi, Ahmed Sayadi, Leandro Simonetti, Emma Nilsson, Muhammad Ali, Johanna Kliche, Ainhoa Moliner Morro, Andreas Mund, Eva Andersson, Gerald McInerney, Matthias Mann, Per Jemth, Norman E. Davey, Anna K. Överby, Jakob Nilsson, Ylva Ivarsson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Many interactions between viral and host proteins are mediated by short peptide motifs. Here, using a phage-based viral peptide library, the authors identify 269 peptide-based interactions for 18 coronaviruses, including an interaction between SARS-C
Externí odkaz:
https://doaj.org/article/1f444706eff944aca145f8ed28412f90
Autor:
Hazem M. Kotb, Norman E. Davey
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 906 (2023)
The identification of protein surfaces required for interaction with other biomolecules broadens our understanding of protein function, their regulation by post-translational modification, and the deleterious effect of disease mutations. Protein inte
Externí odkaz:
https://doaj.org/article/e954734020db46a4b04640c387176586
Autor:
Rajaa Sebaa, Jeff Johnson, Chantal Pileggi, Michaela Norgren, Jian Xuan, Yuka Sai, Qiang Tong, Izabella Krystkowiak, Emma Bondy-Chorney, Norman E. Davey, Nevan Krogan, Michael Downey, Mary-Ellen Harper
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 35-49 (2019)
Objective: Brown adipose tissue (BAT) is important for thermoregulation in many mammals. Uncoupling protein 1 (UCP1) is the critical regulator of thermogenesis in BAT. Here we aimed to investigate the deacetylation control of BAT and to investigate a
Externí odkaz:
https://doaj.org/article/afe2fd5e16c047dbb8b785f6f7720c7f
Autor:
Amanda Bentley-DeSousa, Charlotte Holinier, Houman Moteshareie, Yi-Chieh Tseng, Sam Kajjo, Christine Nwosu, Giuseppe Federico Amodeo, Emma Bondy-Chorney, Yuka Sai, Adam Rudner, Ashkan Golshani, Norman E. Davey, Michael Downey
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3427-3439 (2018)
Summary: Polyphosphates (polyP) are chains of inorganic phosphates found in all cells. Previous work has implicated these chains in diverse functions, but the mechanism of action is unclear. A recent study reports that polyP can be non-enzymatically
Externí odkaz:
https://doaj.org/article/f8e8ebade0a34fae9fcc2b8573b2e513
Autor:
Norman E. Davey, M. Madan Babu, Martin Blackledge, Alan Bridge, Salvador Capella-Gutierrez, Zsuzsanna Dosztanyi, Rachel Drysdale, Richard J. Edwards, Arne Elofsson, Isabella C. Felli, Toby J. Gibson, Aleksandras Gutmanas, John M. Hancock, Jen Harrow, Desmond Higgins, Cy M. Jeffries, Philippe Le Mercier, Balint Mészáros, Marco Necci, Cedric Notredame, Sandra Orchard, Christos A. Ouzounis, Rita Pancsa, Elena Papaleo, Roberta Pierattelli, Damiano Piovesan, Vasilis J. Promponas, Patrick Ruch, Gabriella Rustici, Pedro Romero, Sirarat Sarntivijai, Gary Saunders, Benjamin Schuler, Malvika Sharan, Denis C. Shields, Joel L. Sussman, Jonathan A. Tedds, Peter Tompa, Michael Turewicz, Jiri Vondrasek, Wim F. Vranken, Bonnie Ann Wallace, Kanin Wichapong, Silvio C. E. Tosatto
Publikováno v:
F1000Research, Vol 8 (2019)
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP res
Externí odkaz:
https://doaj.org/article/394ab68cdf814790908372f98b29dde4
Autor:
Richard J. Smith, Marilia H. Cordeiro, Norman E. Davey, Giulia Vallardi, Andrea Ciliberto, Fridolin Gross, Adrian T. Saurin
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2206-2219.e8 (2019)
Summary: PP1 and PP2A-B56 are major serine/threonine phosphatase families that achieve specificity by colocalizing with substrates. At the kinetochore, however, both phosphatases localize to an almost identical molecular space and yet they still mana
Externí odkaz:
https://doaj.org/article/56be128601e84e0e9b4e4487d4343491