Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Norman D. Huebert"'
Autor:
Zhihua Sui, William V. Murray, Celia Jenkinson, Norman D. Huebert, Peter Haug, Michael P. Winters, Wen Yan, James N. Leonard, Yuanping Wang, Arthur T. Suckow, Austin Bell, Tatiana Koudriakova, Hong Hua, Wilmelenne Clapper, Wall Mark, Joseph Gunnet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:841-846
The discovery of a novel series of N-arylpyrroles as agonists of GPR120 (FFAR4) is discussed. One lead compound is a potent GPR120 agonist, has good selectivity for related receptor GPR40 (FFAR1), has acceptable PK properties, and is active in 2 mode
Autor:
Wall Mark, Celia Jenkinson, Zhihua Sui, Michael P. Winters, Tatiana Koudriakova, Norman D. Huebert, James N. Leonard, Yuanping Wang, Austin Bell, Hong Hua, Peter Haug, William V. Murray, Joseph Gunnet, Wilmelenne Clapper, Wen Yan, Arthur T. Suckow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1676-1678
Autor:
Norman D. Huebert, Zhang Rui, Rosie Santulli, Annette Eckardt, Karen DiLoreto, Michael David Gaul, Fengbin Song, Guozhang Xu, Zhao Bao-Ping, Renee L. DesJarlais, Brian C. Shook, Keith T. Demarest, Tianbao Lu, Dennis Rentzeperis
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(15)
A novel series of indazole/indole derivatives were discovered as glucagon receptor (GCGR) antagonists through scaffold hopping based on two literature leads: MK-0893 and LY-2409021. Further structure-activity relationship (SAR) exploration and optimi
Autor:
Simon A. Hinke, Jose Silva, Guozhang Xu, Michael David Gaul, Seunghun Paul Lee, William V. Murray, Norman D. Huebert, Thomas Kirchner, Gee-Hong Kuo, Fuyong Du, Keith T. Demarest, June Zhi Xu, Yin Liang, Nathaniel H. Wallace
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(21)
A new series of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as dual inhibitors of sodium glucose co-transporter proteins (SGLTs) were disclosed. Two methods were developed to efficiently synthesize C5-fluoro-lacton
Autor:
Norman D. Huebert, John R. Mabus, Suzanne E. Thompson, Dalia Levine, Randall J. Brezski, Connie Kliwinski, Salman Muzammil, Courtney B. Bement, Dino Bradley, Philip Cooper, Pamela J. Hornby, Rob Perkinson
Publikováno v:
Pharmacology Research & Perspectives
Although much speculation has surrounded intestinally expressed FcRn as a means for systemic uptake of orally administered immunoglobulin G (IgG), this has not been validated in translational models beyond neonates or in FcRn‐expressing cells in vi
Autor:
Michael K. Hansen, Norman D. Huebert, Charles V. Jackson, Karen M. Zimmerman, Richard G. Peterson, Willem de Winter
Publikováno v:
Journal of Diabetes Research
Journal of Diabetes Research, Vol 2015 (2015)
Journal of Diabetes Research, Vol 2015 (2015)
Metabolic syndrome and T2D produce significant health and economic issues. Many available animal models have monogenic leptin pathway mutations that are absent in the human population. Development of the ZDSD rat model was undertaken to produce a mod
Autor:
Connie Kliwinski, Jeevan Kunta, John R. Mabus, Philip Cooper, Jill Giles-Komar, Norman D. Huebert, Randall J. Brezski, Pamela J. Hornby, Salman Muzammil, Dino Bradley
Publikováno v:
The FASEB Journal. 28
In adult primates, immunoglobulin G (IgG) is not detectable in the serum when taken orally due to enzymatic degradation and low intestinal permeation. Direct IgG infusion (2 mg/kg) into the ileum/p...