Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Norman C. Nelson"'
Autor:
Norman C. Nelson
Publikováno v:
Critical Reviews in Clinical Laboratory Sciences. 35:369-414
The detection of genetic mutations is of paramount importance for the study, diagnosis, and treatment of human genetic disease. Methods of detection generally fall into one of two categories: those to scan for unknown mutations and those to detect kn
Publikováno v:
Biochemistry. 35:8429-8438
The acridinium ester 4-(2-succinimidyloxycarbonylethyl)phenyl-10-methylacridinium 9-carboxylate trifluoromethane sulfonate (AE), which reacts rapidly with alkaline hydrogen peroxide to produce light, has been used as a detection label in a number of
Autor:
Walid A Alturki, Gholam A. Peyman, Christopher L. Paris, Kevin J. Blinder, Norman C Nelson, Uday R. Desai
Publikováno v:
International Ophthalmology. 16:439-444
Local excision of uveal melanoma is an intriguing therapeutic modality in selected cases. An internal choroidectomy under a retinal flap has been developed as an alternative to retinochoroidectomy in managing posterior pole melanomas. This technique
Autor:
Christopher L. Paris, Norman C. Nelson, Ching J. Chen, Uday R. Desai, Walid A. Alturki, Gholam A. Peyman, Kevin J. Blinder
Publikováno v:
Ophthalmology. 99:1542-1547
Background: Suprachoroidal hemorrhage may cause the expulsion of intraocular contents. Generally, cases of nonexpulsive suprachoroidal hemorrhage have a better outcome than their expulsive counterparts. Those cases with massive nonexpulsive suprachor
Autor:
Kevin J. Blinder, Gholam A. Peyman, Christopher L. Paris, Walid A Alturki, Norman C Nelson, Uday R Desai
Publikováno v:
Ophthalmic Surgery, Lasers and Imaging Retina. 23:685-688
Fifteen eyes with complicated retinal detachments-11 with proliferative vitreoretinopathy (C 3 D 3 ), 2 with posterior segment trauma, and 2 with inflammatory retinopathy-were treated with vitrectomy, membrane peeling, and large posterior retinotomy.
Autor:
Kevin J. Blinder, Walid A Alturki, Gholam A. Peyman, U. R. Desai, Norman C Nelson, Christopher L. Paris
Publikováno v:
British Journal of Ophthalmology. 76:525-528
This investigation of the liquid perfluorocarbon, perfluorophenanthrene (Vitreon), establishes its safety and efficacy as a short-term vitreoretinal tamponade. We utilised Vitreon as an intraoperative tool and postoperative vitreoretinal tamponade in
Autor:
Norman C Nelson, Kevin J. Blinder, Uday R Desai, Gholam A. Peyman, Christopher L. Paris, Walid A Alturki
Publikováno v:
Ophthalmic Surgery, Lasers and Imaging Retina. 22:102-108
We describe the surgical excision of submacular scar in end-stage age-related macular degeneration and transplantation of autologous and homologous retinal pigment epithelial (RPE) cells. The technique involves the preparation of a large retinal flap
Publikováno v:
Journal of Bioluminescence and Chemiluminescence. 6:35-43
The chemiluminescent reaction of an acridinium ester (AE) requires addition of peroxide to the 9 position of the acridinium ring. The addition of a hydroxide ion to the 9 position of an acridinium ester to form the carbinol adduct has also been well
Autor:
Norman C. Nelson, Daniel L. Kacian
Publikováno v:
Clinica Chimica Acta. 194:73-90
Nucleic acid hybridization has the potential to markedly improve the diagnosis of infectious and genetic diseases. Recently, chemiluminescent hybridization assays using acridinium esters and stabilized dioxetanes have been described with sensitivitie
Publikováno v:
Biochemistry. 38(17)
A highly chemiluminescent reporter molecule, acridinium ester (AE), was tethered to single-stranded oligonucleotide probes and hybridized to complementary as well as mismatched target sequences. When tethered to single-stranded probes, AE was readily