Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Norman Barnabé"'
Autor:
Norman Barnabé, Billy W. Day, Kwasi S. Avor, Gaik-Lean Chee, Jack C. Yalowich, Padmakumari Thampatty, Brian B. Hasinoff
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:1765-1771
The epipodophyllotoxin etoposide is a potent and widely used anticancer drug that targets DNA topoisomerase II. The synthesis, photochemical, and biological testing of a photoactivatable aromatic azido analogue of etoposide also containing an iodo gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf1933c2bf281d88eb8bf1fb13cf81f
https://doi.org/10.1016/s0968-0896(01)00102-x
https://doi.org/10.1016/s0968-0896(01)00102-x
Autor:
Michael E. Abram, Norman Barnabé, William P. Allan, Brian B. Hasinoff, Jack C. Yalowich, Tayeb Khélifa
Publikováno v:
Molecular Pharmacology. 59:453-461
The bisdioxopiperazines ICRF-187 (dexrazoxane), ICRF-193, and ICRF-154 are catalytic noncleavable complex-forming inhibitors of DNA topoisomerase II that do not produce protein-linked DNA strand breaks. In this study, we showed that bisdioxopiperazin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a342fc710449cf7f475fbe44e305458
https://doi.org/10.1124/mol.59.3.453
https://doi.org/10.1124/mol.59.3.453
Publikováno v:
Cytotechnology. 37:107-117
The effect of dexrazoxane on monoclonal antibody (Mab) production by CC9C10 hybridoma cells was investigated. Dexrazoxane is a catalytic inhibitor of DNA topoisomerase II. DNA topoisomerase II has a critical role in DNA metabolism and its inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64d8908cacecee53f90ea04b19ca18fa
https://doi.org/10.1023/a:1019910213964
https://doi.org/10.1023/a:1019910213964
Autor:
Norman Barnabé, Michael Butler, Martin Berry, D. Moffatt, Megan Patrick, N. Huzel, A. Burgener, Kevin M. Coombs
Publikováno v:
Biotechnology Progress. 16:854-858
Two strains of reovirus (serotype 1 Lang/TIL and serotype 3 Dearing/T3D) were propagated in Vero cells grown in stationary or agitated cultures in a serum-free medium, M-VSFM. Solid microcarriers (Cytodex-1) were used to support cell growth in agitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca89c2665a79dfe22c1c56e8e6c07fa6
https://doi.org/10.1021/bp000110+
https://doi.org/10.1021/bp000110+
Publikováno v:
Biotechnology and Bioengineering. 62:12-19
Two strains of reovirus were propagated in Vero cells grown in stationary or microcarriers cultures. Vero cells grown as monolayers on T-flasks or in spinner cultures of Cytodex-1 or Cultispher-G microcarriers could be infected with reovirus serotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d525d69454e410adf8f2bc320c39fc
https://doi.org/10.1002/(sici)1097-0290(19990105)62:1<12::aid-bit2>3.0.co
https://doi.org/10.1002/(sici)1097-0290(19990105)62:1<12::aid-bit2>3.0.co
Publikováno v:
Cytotechnology. 30:27-36
The murine hybridoma (CC9C10) was subjected to high shear rates in a spinner flask to determine the effect of various culture additives on cell survival. At 500 rpm, the half-life of the viable cell concentration in a low protein serum-free medium wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d39637b6630776052622a6249c51ae
https://doi.org/10.1023/a:1008048126055
https://doi.org/10.1023/a:1008048126055
Publikováno v:
Nitric oxide : biology and chemistry. 9(4)
The clinical use of the widely used anticancer drug doxorubicin is limited by a dose-dependent cardiotoxicity. Doxorubicin can be reduced to its semiquinone free radical form by nitric oxide synthases (NOS). The release of lactate dehydrogenase (LDH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a513b8e4c90bada3d12fb1a8e6f092b
https://pubmed.ncbi.nlm.nih.gov/14996428
https://pubmed.ncbi.nlm.nih.gov/14996428
Publikováno v:
Free radical biologymedicine. 33(2)
The iron chelating hydroxypyridinone deferiprone (CP20, L1) and the clinically approved cardioprotective agent dexrazoxane (ICRF-187) were examined for their ability to protect neonatal rat cardiac myocytes from doxorubicin-induced damage. Doxorubici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b97987680e764bedaf1cc0bea01a50
https://pubmed.ncbi.nlm.nih.gov/12106822
https://pubmed.ncbi.nlm.nih.gov/12106822
Autor:
Brian B. Hasinoff, Norman Barnabé
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 760(2)
A high-throughput fluorescence flow-injection assay is described, suitable for determining the catalytic inhibition of DNA topoisomerase II. The method, which separates high molecular mass trypanosome kinetoplast DNA from its decatenated product by c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa174f4f96f5829f8a407fee18b6a122
https://pubmed.ncbi.nlm.nih.gov/11530985
https://pubmed.ncbi.nlm.nih.gov/11530985
Publikováno v:
Scopus-Elsevier
Growth of the murine B-lymphocyte cell line CC9C10 and the myeloma SP2/0 was enhanced significantly by the presence of the unsaturated fatty acids, oleic and linoleic acids in serum-free culture. The cellular content of linoleic and oleic acids gradu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad72636c2610f1b4b3a21f08981b0a65
https://europepmc.org/articles/PMC1218234/
https://europepmc.org/articles/PMC1218234/
