Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Norman, Stockbridge"'
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Traditional approaches to preclinical drug safety assessment have generally protected human patients from unintended adverse effects. However, these assessments typically occur too late to make changes in the formulation or in phase 1 and beyond, are
Externí odkaz:
https://doaj.org/article/65edf2193e6245698c93414965eb96d2
Autor:
Steven D. Nathan, Peter Fernandes, Mitchell Psotka, Patrizio Vitulo, Lucilla Piccari, Katerina Antoniou, Sylvia M. Nikkho, Norman Stockbridge
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Pulmonary hypertension (PH) associated with interstitial lung disease (ILD) is an attractive target for clinical trials of PH medications. There are many factors that need to be considered to prime such studies for success. The patient pheno
Externí odkaz:
https://doaj.org/article/d86999088ff1414e9be854e1509335f5
Autor:
Sylvia M. Nikkho, Manuel J. Richter, Eric Shen, Steven H. Abman, Katerina Antoniou, Jonathan Chung, Peter Fernandes, Paul Hassoun, Howard M. Lazarus, Horst Olschewski, Lucilla Piccari, Mitchell Psotka, Rajan Saggar, Oksana A. Shlobin, Norman Stockbridge, Patrizio Vitulo, Carmine Dario Vizza, Stephen J. Wort, Steven D. Nathan
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Pulmonary hypertension (PH) has been linked to worse outcomes in chronic lung diseases. The presence of PH in the setting of underlying Interstitial Lung Disease (ILD) is strongly associated with decreased exercise and functional capacity, a
Externí odkaz:
https://doaj.org/article/218979fd55614332832c91abea59ce7c
Autor:
Faiez Zannad, Jacqueline Alikhaani, Sadegh Alikhaani, Javed Butler, Jason Gordon, Klaus Jensen, Rani Khatib, Lorenzo Mantovani, Robin Martinez, Wanda F. Moore, Masahiro Murakami, Lothar Roessig, Norman Stockbridge, Harriette G.C. Van Spall, Clyde Yancy, John A. Spertus
Publikováno v:
European Journal of Heart Failure. 25:478-487
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2af1693c3f96b948abeb9b06a7ba372a
https://doi.org/10.1002/ejhf.2828
https://doi.org/10.1002/ejhf.2828
Autor:
Ksenia Blinova, Qianyu Dang, Daniel Millard, Godfrey Smith, Jennifer Pierson, Liang Guo, Mathew Brock, Hua Rong Lu, Udo Kraushaar, Haoyu Zeng, Hong Shi, Xiaoyu Zhang, Kohei Sawada, Tomoharu Osada, Yasunari Kanda, Yuko Sekino, Li Pang, Tromondae K. Feaster, Ralf Kettenhofen, Norman Stockbridge, David G. Strauss, Gary Gintant
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3582-3592 (2018)
Summary: To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and sources of variability of electrophysiologic responses to 28 dr
Externí odkaz:
https://doaj.org/article/3766b15437f1454ca223759395ad3b34
Autor:
Mitchell A. Psotka, William T. Abraham, Mona Fiuzat, Gerasimos Filippatos, JoAnn Lindenfeld, Tariq Ahmad, G. Michael Felker, Richard Jacob, Dalane W. Kitzman, Eric S. Leifer, Eldrin F. Lewis, Robert J. Mentz, Richard Nkulikiyinka, Wei Ni, Daniel E. Schaber, Abhinav Sharma, Scott D. Solomon, Norman Stockbridge, John R. Teerlink, Ellis F. Unger, David J. Whellan, Janet Wittes, Stefan D. Anker, Christopher M. O’Connor
Publikováno v:
JACC: Heart Failure. 10:889-901
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61c7eca9479b871b054b1a60d35330fc
https://doi.org/10.1016/j.jchf.2022.09.012
https://doi.org/10.1016/j.jchf.2022.09.012
Autor:
Katerina Hnatkova, Jose Vicente, Lars Johannesen, Christine Garnett, David G. Strauss, Norman Stockbridge, Marek Malik
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Electrocardiogram (ECG) studies of drug-induced prolongation of the interval between the J point and the peak of the T wave (JTp interval) distinguished QT prolonging drugs that predominantly block the delayed potassium rectifier current from those a
Externí odkaz:
https://doaj.org/article/1e461617088940808e5f417929811e2f
Autor:
Katerina Hnatkova, Jose Vicente, Lars Johannesen, Christine Garnett, Norman Stockbridge, Marek Malik
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The accuracy of studies of drug-induced QTc changes depends, among others, on the accuracy of heart rate correction of QT interval. It has been recognized that when a drug leads to substantial heart rate changes, fixed universal corrections cannot be
Externí odkaz:
https://doaj.org/article/25a5d8d4e3804103a71d2b5f3e849551
Autor:
Cécile Ollivier, Haihao Sun, Wayne Amchin, Maurice Beghetti, Rolf M. F. Berger, Stefanie Breitenstein, Christine Garnett, Ninna Gullberg, Patrik Hassel, Dunbar Ivy, Steven M. Kawut, Agnes Klein, Catherine Lesage, Marek Migdal, Barbara Nije, Michal Odermarsky, James Strait, Pieter A. de Graeff, Norman Stockbridge
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 10 (2019)
Externí odkaz:
https://doaj.org/article/703b105f8aba4116b102ce695a9d3ef0
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 5, Pp 309-312 (2016)
Externí odkaz:
https://doaj.org/article/c6ec6bb74dc04e499a18ccc7f7415c3d