Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Norman, Pavelka"'
Autor:
Jose Antonio Reales-Calderon, Gloria H. W. Tso, Alrina S. M. Tan, Pei Xiang Hor, Julia Böhme, Karen W. W. Teng, Evan W. Newell, Amit Singhal, Norman Pavelka
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Serial passaging of the human fungal pathogen Candida albicans in the gastrointestinal tract of antibiotics-treated mice selects for virulence-attenuated strains. These gut-evolved strains protect the host from infection by a wide range of pathogens
Externí odkaz:
https://doaj.org/article/b78244ca41df4506bafd59ca00f923e2
Autor:
Fabien Cottier, Alrina Shin Min Tan, Marina Yurieva, Webber Liao, Josephine Lum, Michael Poidinger, Francesca Zolezzi, Norman Pavelka
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 11, Pp 3597-3604 (2017)
Candida albicans is a resident fungus of the human intestinal microflora. Commonly isolated at low abundance in healthy people, C. albicans outcompetes local microbiota during candidiasis episodes. Under normal conditions, members of the human gastro
Externí odkaz:
https://doaj.org/article/e47667bb6a994f699a7cc6bf050161fe
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Candida albicans is a ubiquitous fungal symbiont that resides on diverse human barrier surfaces. Both mammalian and fungal cells can convert arachidonic acid into the lipid mediator, prostaglandin E2 (PGE2), but the physiological significance of fung
Externí odkaz:
https://doaj.org/article/3dfa78692fec45f0a87fd70ccf8bf979
Autor:
Anja Forche, Norma V Solis, Marc Swidergall, Robert Thomas, Alison Guyer, Annette Beach, Gareth A Cromie, Giang T Le, Emily Lowell, Norman Pavelka, Judith Berman, Aimeé M Dudley, Anna Selmecki, Scott G Filler
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008137 (2019)
When the fungus Candida albicans proliferates in the oropharyngeal cavity during experimental oropharyngeal candidiasis (OPC), it undergoes large-scale genome changes at a much higher frequency than when it grows in vitro. Previously, we identified a
Externí odkaz:
https://doaj.org/article/404d9c387d5f45d796ff618e3ff1ebc0
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Candidemia is a bloodstream fungal infection caused by Candida species and is most commonly observed in hospitalized patients. Even with proper antifungal drug treatment, mortality rates remain high at 40–50%. Therefore, prophylactic or preemptive
Externí odkaz:
https://doaj.org/article/e6efb8fe1ec544e2a7e3122d5df26007
Publikováno v:
Molecular Biology and Evolution
Aneuploidy is common both in tumor cells responding to chemotherapeutic agents and in fungal cells adapting to antifungal drugs. Because aneuploidy simultaneously affects many genes, it has the potential to confer multiple phenotypes to the same cell
Autor:
Kong-Peng Lam, Wern Cui Chu, Jianhe Wang, Leo A. B. Joosten, Haishan Wang, Khai Pang Leong, Norman Pavelka, Yuan Qiao, Yue Wang, Fabien Cottier, Marije Oosting, Xiaoli Xu, Zhen-Xing Huang, Shengli Xu, Louis Yi Ann Chai, Mihai G. Netea, Sven Pettersson, Carol Ng, Parag Kundu
Publikováno v:
Nature Microbiology, 4, 766-773
Nature Microbiology, 4, 5, pp. 766-773
Nature Microbiology, 4, 5, pp. 766-773
The human microbiota provides tonic signals that calibrate the host immune response1,2, but their identity is unknown. Bacterial peptidoglycan (PGN) subunits are likely candidates since they are well-known immunity-enhancing adjuvants, released by mo
Autor:
Ghee Chuan Lai, Xiaohui Sem, Giulia Rancati, Michael Poidinger, Marina Yurieva, Jose Antonio Reales-Calderon, Webber Liao, Tze Guan Tan, Gloria Hoi Wan Tso, Giang Thi Thu Le, Kandhadayar G. Srinivasan, Norman Pavelka, Alrina Shin Min Tan, Francesca Zolezzi
Publikováno v:
Science. 362:589-595
Gut microbiota selects fungi Fungi, such as Candida albicans , are found in the mammalian gut, but we know little about what they are doing there. Tso et al. put C. albicans under evolutionary pressure by serial passage in mice that were treated with
Autor:
Leong Jing Yao, Ravid Straussman, Avery Khoo May Lee, Kalyani Srinivasan, Gurmit Singh Naranjan Singh, David Vermijlen, Fabien Cottier, Nurhidaya Binte Shadan, Costerwell Khyriem, Gillian Low, Garold Fuks, Mahesh Choolani, Noam Shental, Salvatore Albani, Xiao Meng Zhang, Thet Tun Aung, Rhea Pai, Charles-Antoine Dutertre, Aviva Rotter-Maskowitz, Benoit Malleret, Archita Mishra, Svetoslav Chakarov, Adhika Shanti, Ghee Chuan Lai, Naomi McGovern, Regina Men Men Wong, Jerry Kok Yen Chan, Edwin Shepherdson, Alrina Shin Min Tan, Andrea Lee, Ankur Sharma, Pei Xiang Hor, Florent Ginhoux, Yiping Fan, Norman Pavelka, Shabnam Khalilnezhad, Phyllis Chen
Publikováno v:
Cell
Summary The human fetal immune system begins to develop early during gestation; however, factors responsible for fetal immune-priming remain elusive. We explored potential exposure to microbial agents in utero and their contribution toward activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e717df9ca3dcab66112e89736ba9203
Autor:
Flora Teoh, Norman Pavelka
Publikováno v:
Pathogens, Vol 5, Iss 1, p 6 (2016)
Candida albicans is a fungal commensal and a major colonizer of the human skin, as well as of the gastrointestinal and genitourinary tracts. It is also one of the leading causes of opportunistic microbial infections in cancer patients, often presenti
Externí odkaz:
https://doaj.org/article/884dd6ece1c1499fa7a3eaa334e1b50f