Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Norman, Mack"'
Autor:
Kristian W. Pajtler, Yiju Wei, Konstantin Okonechnikov, Patricia B. G. Silva, Mikaella Vouri, Lei Zhang, Sebastian Brabetz, Laura Sieber, Melissa Gulley, Monika Mauermann, Tatjana Wedig, Norman Mack, Yuka Imamura Kawasawa, Tanvi Sharma, Marc Zuckermann, Felipe Andreiuolo, Eric Holland, Kendra Maass, Huiqin Körkel-Qu, Hai-Kun Liu, Felix Sahm, David Capper, Jens Bunt, Linda J. Richards, David T. W. Jones, Andrey Korshunov, Lukas Chavez, Peter Lichter, Mikio Hoshino, Stefan M. Pfister, Marcel Kool, Wei Li, Daisuke Kawauchi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The molecular mechanisms driving proliferation in the pediatric brain cancer epdendymoma are poorly understood. Here the authors show that a YAP1- MAMLD1 fusion drives tumor formation in mice and show that the fusion protein can collaborate with the
Externí odkaz:
https://doaj.org/article/adf1b461d84d45cc809ee416ce32b241
Autor:
Lavinia Arseni, Rakesh Sharma, Norman Mack, Deepthi Nagalla, Sibylle Ohl, Thomas Hielscher, Mahak Singhal, Robert Pilz, Hellmut Augustin, Roger Sandhoff, Christel Herold-Mende, Björn Tews, Peter Lichter, Martina Seiffert
Publikováno v:
Cancers; Volume 15; Issue 2; Pages: 479
Glioblastoma is the most aggressive brain tumor in adults. Treatment failure is predominantly caused by its high invasiveness and its ability to induce a supportive microenvironment. As part of this, a major role for tumor-associated macrophages/micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b53baf11b5e641b5dc5b8f4edd08c50
Autor:
Marc Zapatka, Debus Jürgen, Stephan Brons, Mahmoud Moustafa, Umar Khalid, Pei-Chi Wei, John Wong, Daniel Hübschmann, Michiel Bolkestein, Sabine Heiland, Martin Bendszus, Milena Simovic, Amir Abdollahi, Verena Körber, Hannah Sophia Schreiber, Aurélie Ernst, Sarah Benedetto, Manfred Jugold, Michael O. Breckwoldt, Andrey Korshunov, Thomas Höfer, Stefan M. Pfister, Norman Mack, Marcel Kool
Publikováno v:
Neuro Oncol
Background Medulloblastomas with chromothripsis developing in children with Li-Fraumeni Syndrome (germline TP53 mutations) are highly aggressive brain tumors with dismal prognosis. Conventional photon radiotherapy and DNA-damaging chemotherapy are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd6b7082a9f7710fb53cc46ea162087
https://doi.org/10.1093/neuonc/noab127
https://doi.org/10.1093/neuonc/noab127
Autor:
Apurva Gopisetty, Aniello Federico, Didier Surdez, Yasmine Iddir, Sakina Zaidi, Alexandra Saint-Charles, Joshua Waterfall, Elnaz Saberi-Ansari, Justyna Wierzbinska, Andreas Schlicker, Norman Mack, Benjamin Schwalm, Christopher Previti, Lena Weiser, Ivo Buchhalter, Anna-Lisa Böttcher, Martin Sill, Robert Autry, Frank Estermann, David Jones, Richard Volckmann, Danny Zwijnenburg, Angelika Eggert, Olaf Heidenreich, Fatima Iradier, Irmela Jeremias, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Petra Hamerlik, Maureen Hattersley, Olaf Witt, Louis Chesler, Alan Mackay, Johannes Gojo, Stefano Cairo, Julia Schueler, Johannes Schulte, Birgit Geoerger, Jan J. Molenaar, David J. Shields, Hubert N. Caron, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Natalie Jaeger, Jan Koster, Marcel Kool, Gudrun Schleiermacher
Publikováno v:
Cancer Research. 83:234-234
Advancements in state-of-the-art molecular profiling techniques have resulted in better understanding of pediatric cancers and driver events. It has become apparent that pediatric cancers are significantly more heterogeneous than previously thought a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9f689ca14428d824522f9a30f511100
https://doi.org/10.1158/1538-7445.am2023-234
https://doi.org/10.1158/1538-7445.am2023-234
Autor:
Apurva Gopisetty, Aniello Federico, Didier Surdez, Elnaz Saberi-Ansari, Yasmine Iddir, Alexandra Saint-Charles, Joshua Waterfall, Justyna Wierzbinska, Andreas Schlicker, Norman Mack, Benjamin Schwalm, David T Jones, Johannes Gojo, Louis Chesler, Gilles Vassal, Lou Stancato, Jan Koster, Jan J Molenaar, Natalie Jaeger, Gudrun Schleiermacher, Stefan Pfister, Marcel Kool
Publikováno v:
Neuro-Oncology. 24:vii126-vii127
Advancements in state-of-the-art molecular profiling techniques has resulted in better understanding of pediatric cancers and their drivers. Conversely, it also became apparent that pediatric cancers are much more heterogeneous than previously though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c43a31fe055855349266fd37f77f0de
https://doi.org/10.1093/neuonc/noac209.481
https://doi.org/10.1093/neuonc/noac209.481
Autor:
Simon Feyerabend, Thorsten Rieckmann, Britta Riepen, Agnes Oetting, Sabrina Christiansen, Melanie Schoof, Annika Hardt, Sabrina Köcher, Julia Neumann, Rudolf Schwarz, Norman Mack, Benjamin Schwalm, Aniello Federico, Till Milde, Marcel Kool, Ulrich Schüller, Stefan Rutkowski, Cordula Petersen, Kai Rothkamm, Martin Mynarek, Nina Struve
Publikováno v:
Neuro-Oncology. 24:i117-i118
Medulloblastoma (WHO grade 4) is the most common malignant brain tumor of childhood. Despite the high importance of radiotherapy for disease control, the mechanisms underlying response and resistance to radiotherapy are incompletely understood. There
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b99de9f98d6107b7c41efee516ea917e
https://doi.org/10.1093/neuonc/noac079.424
https://doi.org/10.1093/neuonc/noac079.424
Autor:
Anna Kolodziejczak, Florian Selt, Heike Peterziel, Nora Jamaladdin, Norman Mack, Kendra Maass, Marcel Kool, Christel Herold-Mende, Ahmed El Damaty, Ina Oehme, David T W Jones, Olaf Witt, Kristian W Pajtler, Christian Kratz, Stefan M Pfister, Till Milde
Publikováno v:
Neuro-Oncology. 24:i168-i169
INTRODUCTION: Disorders with Abnormal DNA Damage Response/Repair (DADDRs) are inherited conditions caused by constitutional mutations of DNA damage response and repair genes and are characterized by an increased cancer risk. Furthermore, affected ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c572db841976684cc8e69c12da9514c6
https://doi.org/10.1093/neuonc/noac079.627
https://doi.org/10.1093/neuonc/noac079.627
Autor:
Hai-Kun Liu, Peter Lichter, Tatjana Wedig, Wei Li, Felix Sahm, Huiqin Körkel-Qu, Yuka Imamura Kawasawa, Jens Bunt, Kristian W. Pajtler, Eric C. Holland, Sebastian Brabetz, David Capper, Konstantin Okonechnikov, David T.W. Jones, Lei Zhang, Marc Zuckermann, Lukas Chavez, Stefan M. Pfister, Felipe Andreiuolo, Norman Mack, Daisuke Kawauchi, Yiju Wei, Marcel Kool, Laura Sieber, Linda J. Richards, Andrey Korshunov, Melissa Gulley, Mikio Hoshino, Kendra K. Maass, Monika Mauermann, Patricia Benites Goncalves da Silva, Mikaella Vouri, Tanvi Sharma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 fusions are sufficient to drive malignant transformation in mice, and the resulting tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2246b3de4157e2f5f986ecc728bd189
https://doaj.org/article/adf1b461d84d45cc809ee416ce32b241
https://doaj.org/article/adf1b461d84d45cc809ee416ce32b241
Autor:
Eva Oswald, Kanstantsin Lashuk, Johannes Gojo, Dorothee Lenhard, Norman Mack, Sonja Krausert, Daniela Lötsch, David Jones, Marcel Kool, Till Milde, Walter Berger, Stefan M. Pfister, Julia Schüler
Publikováno v:
Cancer Research. 82:1673-1673
Brain and spinal cord tumors are the second most common group of cancers in children. For children who experience relapses of their tumors, usually after very intensive first-line therapy, curative treatment options are scarce. Thus, the need for pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24b0e25302593e0c67468d8692c421fd
https://doi.org/10.1158/1538-7445.am2022-1673
https://doi.org/10.1158/1538-7445.am2022-1673
Autor:
Patricia Benites Goncalves da Silva, Laura Sieber, Norman Mack, Daniel Atar, Lena M Kutscher, Patrick Schlegel, Martin Ebinger, Daisuke Kawauchi, Christian Seitz, Stefan M Pfister
Publikováno v:
Neuro-Oncology. 24:i83-i83
Brain tumors are the most frequent category of solid tumors in children and have the highest mortality rate among all pediatric cancers. Although diagnosis and treatment have improved prognosis over the past decades for some childhood brain tumors, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b36ebc8e6395fe2541e474926e4bb548
https://doi.org/10.1093/neuonc/noac079.304
https://doi.org/10.1093/neuonc/noac079.304