Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination.

Autor: Lopez-Lee, Chloe, Kodama, Lay, Fan, Li, Zhu, Daphne, Zhu, Jingjie, Wong, Man Ying, Ye, Pearly, Norman, Kendra, Foxe, Nessa R., Ijaz, Laraib, Yu, Fangmin, Chen, Hao, Carling, \Gillian K., Torres, Eileen R., Kim, Rachel D., Dubal, Dena B., Liddelow, Shane A., Sinha, Subhash C., Luo, Wenjie, Gan, Li

Publikováno v: Science; 11/29/2024, Vol. 386 Issue 6725, p988-988, 1p, 1 Diagram

APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition.

Autor: Naguib S; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY.; Authors contributed equally., Torres ER; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY.; Authors contributed equally., Lopez-Lee C; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY.; Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY.; Authors contributed equally., Fan L; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Bhagwat M; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Norman K; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Lee SI; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Zhu J; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Ye P; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Wong MY; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Patel T; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Mok SA; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Luo W; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Sinha S; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Zhao M; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Gong S; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Gan L; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY.; Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 28. Date of Electronic Publication: 2024 Apr 28.

Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging.

Autor: Lopez-Lee C; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY.; Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY., Kodama L; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY.; Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA., Fan L; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Wong MY; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Foxe NR; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Jiaz L; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Yu F; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Ye P; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Zhu J; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Norman K; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Torres ER; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Kim RD; Neuroscience Institute, NYU Grossman School of Medicine, New York, NY., Mousa GA; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Dubal D; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA., Liddelow S; Neuroscience Institute, NYU Grossman School of Medicine, New York, NY.; Department of Neuroscience & Physiology, NYU Grossman School of Medicine, New York, NY.; Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY.; Parekh Center for Interdisciplinary Neurology, NYU Grossman School of Medicine, New York, NY., Luo W; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY., Gan L; Helen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY.; Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 21. Date of Electronic Publication: 2023 Sep 21.