Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Norma Roncal"'
Autor:
Dorjbal Dorjsuren, Richard T. Eastman, Kathryn J. Wicht, Daniel Jansen, Daniel C. Talley, Benjamin A. Sigmon, Alexey V. Zakharov, Norma Roncal, Andrew T. Girvin, Yevgeniya Antonova-Koch, Paul M. Will, Pranav Shah, Hongmao Sun, Carleen Klumpp-Thomas, Sachel Mok, Tomas Yeo, Stephan Meister, Juan Jose Marugan, Leila S. Ross, Xin Xu, David J. Maloney, Ajit Jadhav, Bryan T. Mott, Richard J. Sciotti, Elizabeth A. Winzeler, Norman C. Waters, Robert F. Campbell, Wenwei Huang, Anton Simeonov, David A. Fidock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The spread of Plasmodium falciparum parasites resistant to most first-line antimalarials creates an imperative to enrich the drug discovery pipeline, preferably with curative compounds that can also act prophylactically. We report a phenotyp
Externí odkaz:
https://doaj.org/article/3166e3dd3b5945e88b4f3c4eb22c8065
Autor:
Diana Caridha, Mark Hickman, Lisa Xie, Franklyn Ngundam, Erin Milner, Amanda Schenk, Kirk Butler, Dylan Nugent, Patricia Lee, Norma Roncal, Susan Leed, Eve Hosford, Jangwoo Lee, Richard J. Sciotti, Gregory Reichard, Chad Black, Mara Kreishman-Deitrick, Qigui Li, Brian Vesely
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-15 (2019)
Abstract Background Rodent malaria models are extensively used to predict treatment outcomes in human infections. There is a constant need to improve and refine these models by innovating ways to apply new scientific findings and cutting edge technol
Externí odkaz:
https://doaj.org/article/b2caeece80d94ce2ab66bc1e98c7f17b
Autor:
David J Bacon, Doug Tang, Carola Salas, Norma Roncal, Carmen Lucas, Lucia Gerena, Lorena Tapia, A Alejandro Llanos-Cuentas, Coralith Garcia, Lelv Solari, Dennis Kyle, Alan J Magill
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6762 (2009)
Sulfadoxine-pyrimethamine was a common first line drug therapy to treat uncomplicated falciparum malaria, but increasing therapeutic failures associated with the development of significant levels of resistance worldwide has prompted change to alterna
Externí odkaz:
https://doaj.org/article/5eaa2a289372484ea25691ed64a45ded
Autor:
Roland A. Cooper, Susan E. Leed, Qiang Zeng, Kevin A. Reynolds, Lacy Gaynor-Ohnstad, Lisa Xie, Hsiuling Lin, Jason C. Sousa, Jianbing Mu, Heather Gaona, Raul Olmeda, Martin J. Smilkstein, Brett R. Bayles, Brittney Potter, Michael K. Riscoe, Richard J. Sciotti, Papireddy Kancharla, Yuexin Li, Brian Vesely, Sovitj Pou, Sean R. Marcsisin, Chau Vuong, Qigui Li, Brandon S. Pybus, Lisa Read, Victor Melendez, Norma Roncal, Thu Lan Luong, Diana Caridha, Chad C. Black, Rozalia A. Dodean, Jing Zhang, Kirk Butler, Patrick K Tumwebaze, Charles E. Bane, Philip J. Rosenthal, Stephanie A Rasmussen, Mara Kreishman-Deitrick, Jane Xu Kelly, Frida G. Ceja, Ping Zhang, Christina K. Nolan
Publikováno v:
J Med Chem
The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for p
Autor:
Julia Medeiros Souza, Everton M Silva, Jessey Erath, Diane Thomas, James H. McKerrow, Lori Ferrins, Baljinder Singh, Erica Penn, Robert F. Campbell, Jair L. Siqueira-Neto, Ana Rodriguez, Jean A. Bernatchez, Susan E. Leed, Norma Roncal, Hitesh B. Jalani, Jasmin Ackermann, Michael P. Pollastri, Dana M. Klug, Laura-Isobel McCall, Kelly A. Bachovchin, Claudia M. Calvet, Richard J. Sciotti, Seema Bag, Melissa J. Buskes
Publikováno v:
ACS Med Chem Lett
[Image: see text] Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against Trypanosoma brucei, plus 31 new compounds, against a variety of protozoan parasites includin
Autor:
Paul M Will, Wenwei Huang, Stephan Meister, Dorjbal Dorjsuren, Anton Simeonov, Bryan T. Mott, Andrew T Girvin, Pranav Shah, David A. Fidock, Daniel C. Talley, Benjamin A Sigmon, Richard T. Eastman, Xin Xu, Sachel Mok, Leila S. Ross, Tomas Yeo, Daniel J. Jansen, Robert F. Campbell, Alexey V. Zakharov, Richard J. Sciotti, Carleen Klumpp-Thomas, Yevgeniya Antonova-Koch, Norman C. Waters, Juan J. Marugan, Norma Roncal, Elizabeth A. Winzeler, David J. Maloney, Kathryn J. Wicht, Ajit Jadhav, Hongmao Sun
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
The spread of Plasmodium falciparum parasites resistant to most first-line antimalarials creates an imperative to enrich the drug discovery pipeline, preferably with curative compounds that can also act prophylactically. We report a phenotypic quanti
Autor:
Gautam Patel, Jessey Erath, Ana Rodriguez, Jennifer L. Woodring, Norma Roncal, Richard J. Sciotti, Baljinder Singh, Michael P. Pollastri, Erica Penn, Emanuele Amata, Amrita Sharma, Justin Wiedeman, Susan E. Leed, Paul J. Guyett, Ranjan Behera, Kojo Mensa-Wilmot
Publikováno v:
ACS Medicinal Chemistry Letters. 9:996-1001
[Image: see text] Discovery of new chemotherapeutic lead agents can be accelerated by optimizing chemotypes proven to be effective in other diseases to act against parasites. One such medicinal chemistry campaign has focused on optimizing the anilino
Autor:
Sean R. Marcsisin, Norma Roncal, Lisa Read, Qigui Li, Lisa Xie, Qiang Zeng, Jason C. Sousa, Mark Hickman, Chau Vuong, Jing Zhang, Diana Caridha, Brittney Potter, Ping Zhang
Publikováno v:
Malaria Research and Treatment, Vol 2017 (2017)
Malaria Research and Treatment
Malaria Research and Treatment
Decoquinate nanoparticle and microparticle suspended in an oily vehicle to retard drug release are evaluated for long-term malaria prophylaxis. Pharmacokinetic studies in normal animals and antimalarial efficacy in liver stage malaria mice were condu
Autor:
Norma Roncal, Lisa Xie, Lisa Read, Mark Hickman, Ping Zhang, Qiang Zeng, Qigui Li, Jing Zhang, Diana Caridha
Publikováno v:
Military Medicine. 182:360-368
Background: The liver stages of Plasmodium parasites are important targets for the discovery and development of prophylactic drugs. Methods: A real-time in vivo imaging system was used to determine the level of luminescence measured from firefly luci
Autor:
Yuexin Li, Kirk Butler, Brittney Potter, Qigui Li, Papireddy Kancharla, Roland A. Cooper, Thu Lan Luong, Heather Gaona, Jing Zhang, Richard J. Sciotti, Brian Vesely, Chau Vuong, Qiang Zeng, Sean R. Marcsisin, Michael K. Riscoe, Diana Caridha, Jason C. Sousa, Rolf W. Winter, Norma Roncal, Christina K. Nolan, Lisa Read, Rozalia A. Dodean, Lisa Xie, Lacy Gaynor-Ohnstad, Stephanie J. Huezo, Susan E. Leed, Hsiuling Lin, John C. Tan, Martin J. Smilkstein, Stephanie A Rasmussen, Jane Xu Kelly, Ping Zhang, Chad C. Black, Melissa T. Stephens, Mara Kreishman-Deitrick, Raul Olmeda, Victor Melendez, Sovitj Pou, Charles E. Bane
Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351c0f6f16032d54883ac7a5e8be555b
https://europepmc.org/articles/PMC6822569/
https://europepmc.org/articles/PMC6822569/