Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Norma P. Gerard"'
Autor:
Francesca Polverino, Bao Lu, Joselyn Rojas Quintero, Sara O. Vargas, Avignat S. Patel, Caroline A. Owen, Norma P. Gerard, Craig Gerard, Manuela Cernadas
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Cystic fibrosis (CF) is an inherited disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that promotes persistent lung infection and inflammation and progressive loss of lung function. Patients w
Externí odkaz:
https://doaj.org/article/20e5e7499f164f06a667283296ea1eb2
Autor:
Wang Wang, Ratnadeep Basu, Norma P. Gerard, Josef M. Penninger, Mengcheng Shen, Michel Bouvier, Faqi Wang, Conrad Fischer, Sandra Toth, Manish Paul, Pierre Couvineau, Zamaneh Kassiri, Saugata Hazra, Marko Poglitsch, John C. Vederas, Gavin Y. Oudit, Doran Mix
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Vascular diseases remain a major health burden, and AAAs lack effective medical therapy. We demonstrate a seminal role for APLN in AAA pathogenesis based on loss-of-function and gain-of-function approaches and included human vascular SMC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d1c4299575c3547a1e37f093149633
http://europepmc.org/articles/PMC6600956
http://europepmc.org/articles/PMC6600956
Autor:
Avignat S. Patel, Manuela Cernadas, Norma P. Gerard, Caroline A. Owen, Sara O. Vargas, Bao Lu, Craig Gerard, Francesca Polverino, Joselyn Rojas Quintero
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-13 (2019)
Respiratory Research
Respiratory Research
Background Cystic fibrosis (CF) is an inherited disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that promotes persistent lung infection and inflammation and progressive loss of lung function. Patients with CF ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99e95ee15c4249116c8dd27633b7def
https://doi.org/10.1186/s12931-019-1103-1
https://doi.org/10.1186/s12931-019-1103-1
Autor:
Andrew Jerome, Pushpa Rao, Norma P. Gerard, Subhash Gaddipati, Bala Bharathi Burugula, Susmit Suvas
Publikováno v:
The Journal of Immunology. 197:4021-4033
Substance P neuropeptide and its receptor, neurokinin-1 receptor (NK1R), are reported to present on the ocular surface. In this study, mice lacking functional NK1R exhibited an excessive desquamation of apical corneal epithelial cells in association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d610af0c7af31d96132d6078d4e3e6
https://doi.org/10.4049/jimmunol.1600836
https://doi.org/10.4049/jimmunol.1600836
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 55:657-666
LPS-induced lung injury in the mouse is one of the most robust experimental models used for studies of acute lung injury (ALI) and acute respiratory distress syndrome in humans. Prior clinical and experimental studies support an important role for co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361a17012151f6e193fdaaa735a174be
https://doi.org/10.1165/rcmb.2016-0067oc
https://doi.org/10.1165/rcmb.2016-0067oc
Publikováno v:
Immunobiology. 225:151895
Signal transduction by the Toll-like receptors (TLRs) is a key component of innate immunity against many pathogens and also underlies a large burden of human diseases. Therefore, the mechanisms and regulation of signaling from the TLRs are of conside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2aedf2ff6930c4c749933359787146
https://doi.org/10.1016/j.imbio.2019.12.004
https://doi.org/10.1016/j.imbio.2019.12.004
Autor:
Norma P. Gerard, Juan Manuel González-Rosa, Niranjana Natarajan, Lucas H. Cocco-Delgado, Michka Sharpe, Calum A. MacRae, Nhi Ngoc Ho, Jessica L. Whited, Aysu Uygur, Craig Gerard, Caroline E. Burns, Richard T. Lee, Donald M. Bryant, C. Geoffrey Burns, Yamen Abbas
Background: Defining conserved molecular pathways in animal models of successful cardiac regeneration could yield insight into why adult mammals have inadequate cardiac regeneration after injury. Insight into the transcriptomic landscape of early car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cb6ef7050ede78259f1cfee645a4cb
https://europepmc.org/articles/PMC5953786/
https://europepmc.org/articles/PMC5953786/
Autor:
Thomas R. Kleyman, Christine Fillmore Brainson, Chantelle Simone-Roach, Hongmei Lisa Li, Ruobing Wang, Klaus Schmitz-Abe, Tin Louie, Pankaj B. Agrawal, Jiahai Shi, Shaohu Sheng, Mary J. Emond, Michael J. Bamshad, Craig Gerard, Carla F. Kim, Meghan C. Towne, Jingxin Chen, Michael A. Matthay, Norma P. Gerard
Publikováno v:
American journal of respiratory cell and molecular biology, vol 57, iss 6
Cystic fibrosis (CF) remains the most lethal genetic disease in the Caucasian population. However, there is great variability in clinical phenotypes and survival times, even among patients harboring the same genotype. We identified five patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cc7040ce6f96f4408b243cf084bd78
https://escholarship.org/uc/item/9474166t
https://escholarship.org/uc/item/9474166t
Autor:
Mark E. T. Penfold, Ronald J. Falk, Juan C. Jaen, Lin Gan, Daniel J. Dairaghi, Bao Lu, Thomas J. Schall, Lisa Seitz, Peiqi Hu, Craig Gerard, J. Charles Jennette, Norma P. Gerard, Hong Xiao, Yu Wang, Trageen Baumgart, Jay P. Powers, Linda S. Ertl
Publikováno v:
Journal of the American Society of Nephrology. 25:225-231
Necrotizing and crescentic GN (NCGN) with a paucity of glomerular immunoglobulin deposits is associated with ANCA. The most common ANCA target antigens are myeloperoxidase (MPO) and proteinase 3. In a manner that requires activation of the alternativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::179c872b8b6f873b21c994ff66c7c51a
https://doi.org/10.1681/asn.2013020143
https://doi.org/10.1681/asn.2013020143
Publikováno v:
The Journal of Immunology. 191:4001-4009
The complement anaphylatoxin C5a is a critical mediator of allergic contact dermatitis, bridging essential aspects of innate and adaptive immunity. This anaphylatoxin functions by interacting with two 7-transmembrane segment receptors, the C5aR and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ebf92289d79f6b5f5897c7b91b9180a
https://doi.org/10.4049/jimmunol.1301626
https://doi.org/10.4049/jimmunol.1301626