Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Norma N. Anderson"'
Autor:
Xiaorong Fu, Stanisław Deja, Justin A. Fletcher, Norma N. Anderson, Monika Mizerska, Gonçalo Vale, Jeffrey D. Browning, Jay D. Horton, Jeffrey G. McDonald, Matthew A. Mitsche, Shawn C. Burgess
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Fat synthesis is necessary for normal physiology, but its dysregulation contributes to the pathology of many diseases. Here, the authors report a high-resolution mass spectrometry approach that quantifies fat synthesis flux in humans and mice followi
Externí odkaz:
https://doaj.org/article/b1cab25a3bac4392a10db218cc30d323
Autor:
Shunxing Rong, Víctor A Cortés, Shirya Rashid, Norma N Anderson, Jeffrey G McDonald, Guosheng Liang, Young-Ah Moon, Robert E Hammer, Jay D Horton
Publikováno v:
eLife, Vol 6 (2017)
The synthesis of cholesterol and fatty acids (FA) in the liver is independently regulated by SREBP-2 and SREBP-1c, respectively. Here, we genetically deleted Srebf-2 from hepatocytes and confirmed that SREBP-2 regulates all genes involved in choleste
Externí odkaz:
https://doaj.org/article/7a399467622743c8aff8f96e1e76e2be
Autor:
Leigh Goedeke, Miguel A. Lasunción, Alberto Canfrán-Duque, Norma N. Anderson, Noemi Rotllan, Anders M. Näär, Alexandre Wagschal, Jay D. Horton, Elisa Araldi, Juan F. Aranda, Yajaira Suárez, Cristina M. Ramírez, Carlos Fernández-Hernando, Rafael de Cabo, Chin Sheng Lin
Publikováno v:
Nature Medicine. 21:1280-1289
The hepatic low-density lipoprotein receptor (LDLR) pathway is essential for clearing circulating LDL cholesterol (LDL-C). Whereas the transcriptional regulation of LDLR is well characterized, the post-transcriptional mechanisms that govern LDLR expr
Autor:
Norma N. Anderson, Chai Wan Kim, Marcie Ruddy, Manu V. Chakravarthy, Jun Kusunoki, Stuart Milstein, Carol Addy, Jay D. Horton, Steve Previs, David E. Kelley, Xiaorong Fu, Stanislaw Deja, Shawn C. Burgess, Kevin Fitzgerald, Cai Li
Publikováno v:
Cell metabolism. 26(3)
Inhibiting lipogenesis prevents hepatic steatosis in rodents with insulin resistance. To determine if reducing lipogenesis functions similarly in humans, we developed MK-4074, a liver-specific inhibitor of acetyl-CoA carboxylase (ACC1) and (ACC2), en
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 58, Iss 8, Pp 1661-1669 (2017)
Journal of Lipid Research, Vol 58, Iss 8, Pp 1661-1669 (2017)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that targets LDL receptors (LDLRs) for degradation in liver. Blocking the interaction of PCSK9 with the LDLR potently reduces plasma LDL cholesterol levels and cardiovascular
Autor:
Shirya Rashid, Norma N. Anderson, Guosheng Liang, Shunxing Rong, Young Ah Moon, Jeffrey G. McDonald, Jay D. Horton, Robert E. Hammer, Víctor Cortés
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
The synthesis of cholesterol and fatty acids (FA) in the liver is independently regulated by SREBP-2 and SREBP-1c, respectively. Here, we genetically deleted Srebf-2 from hepatocytes and confirmed that SREBP-2 regulates all genes involved in choleste
Autor:
Robert E. Hammer, Jay D. Horton, Norma N. Anderson, Young Ah Moon, Jeffrey G. McDonald, Guosheng Liang, Shirya Rashid, Shunxing Rong, Víctor Cortés
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::304969f61a9bde5e518fa143a07b2738
https://doi.org/10.7554/elife.25015.015
https://doi.org/10.7554/elife.25015.015
Autor:
Yang Xie, Peter Igarashi, Kristina Garland, Matthew A. Mitsche, Norma N. Anderson, Karam Aboudehen, Marco Pontoglio, Russell A. DeBose-Boyd, Lama Noureddine, Vishal Patel, Min Kim
HNF-1β is a tissue-specific transcription factor that is expressed in the kidney and other epithelial organs. Humans with mutations in HNF-1β develop kidney cysts, and HNF-1β regulates the transcription of several cystic disease genes. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc29ef48e21a90ff67a14ccb5d597e3
https://europepmc.org/articles/PMC4978044/
https://europepmc.org/articles/PMC4978044/
Autor:
K. Narayanannair Jayaprakash, Maria Frank-Kamenetsky, Daniel G. Anderson, Robert Langer, Yupeng Fan, Tracy Zimmermann, Muthiah Manoharan, Ingo Röhl, Kevin Fitzgerald, Timothy Racie, Martin Maier, Christina Gamba-Vitalo, Jürgen Soutschek, Akin Akinc, Norma N. Anderson, Lubomir Nechev, Pamela Tan, Muthusamy Jayaraman, Gang Wang, Philipp Hadwiger, Jay D. Horton, Klaus Charisse, Victor Koteliansky, Aldo Grefhorst, David Butler, Matthias John, Antonin de Fougerolles, Robert Dorkin, Timothy Read, Birgit Bramlage, Hans-Peter Vornlocher, Jamie Wong, Kallanthottathil G. Rajeev
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 105(33), 11915-11920. National Academy of Sciences
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates low density lipoprotein receptor (LDLR) protein levels and function. Loss of PCSK9 increases LDLR levels in liver and reduces plasma LDL cholesterol (LDLc), whereas excess PCSK9 activity
Autor:
Thomas A. Lagace, David E. Curtis, Markey C. McNutt, Heidi B. Prather, Norma N. Anderson, Y. K. Ho, Robert E. Hammer, Rita Garuti, Sahng Wook Park, Jay D. Horton
Publikováno v:
Journal of Clinical Investigation. 116:2995-3005
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proteinase K subfamily of subtilases that reduces the number of LDL receptors (LDLRs) in liver through an undefined posttranscriptional mechanism. We show that purified PCSK9 ad