Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Norma Lindsey Buchanan"'
Publikováno v:
AAPS PharmSciTech. 13:1230-1235
For poorly soluble weak bases, the possibility of drug precipitation upon entry into the small intestine may affect the amount of drug available for uptake through the intestinal mucosa. A few years ago, a transfer model was introduced which has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebcf8239cf7504eefcfc81689cd1c29
https://doi.org/10.1208/s12249-012-9851-y
https://doi.org/10.1208/s12249-012-9851-y
Autor:
Norma Lindsey Buchanan, Michael G. Ramsey, Kevin J. Edgar, Thomas Zoeller, Charles Michael Buchanan, Sandra Klein, Juanelle Little Lambert, Michael F. Wempe
Publikováno v:
Journal of Pharmacy and Pharmacology. 61:23-30
Objectives Glyburide, an important drug for type 2 diabetes, has extremely poor aqueous solubility and resulting low bioavailability. This study describes the ability of hydroxybutenyl-β-cyclodextrin (HBenBCD) to form complexes with glyburide, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea30c742974778c6b7212156d7ea93ff
https://doi.org/10.1211/jpp.61.01.0004
https://doi.org/10.1211/jpp.61.01.0004
Autor:
Sandra Klein, Michael G. Ramsey, Charles Michael Buchanan, Kevin J. Edgar, Norma Lindsey Buchanan, Vincent J. Wacher, James L. Little, Michael F. Wempe, Karen M. Ruble
Publikováno v:
Journal of Pharmaceutical Sciences. 96:3100-3116
The current research evaluated and compared the efficacy of hydroxybutenyl-beta-cyclodextrin (HBenBCD) and hydroxypropyl-beta-cyclodextrin (HPBCD) as enhancers of itraconazole solubility and oral bioavailability. At 10 wt% cyclodextrin, 17-fold and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215e591953e1ebe8a9d53ded89ccc402
https://doi.org/10.1002/jps.20878
https://doi.org/10.1002/jps.20878
Autor:
Michael Orlando Malcolm, Karen M. Ruble, Vincent J. Wacher, Michael F. Wempe, Kevin J. Edgar, Norma Lindsey Buchanan, James L. Little, Charles Michael Buchanan
Publikováno v:
Journal of Pharmaceutical Sciences. 96:644-660
Oral and intravenous administration of tamoxifen base and tamoxifen citrate formulated with hydroxybutenyl-beta-cyclodextrin (HBenBCD) to Sprague-Dawley rats significantly increased the oral bioavailability of tamoxifen relative to that of parent dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b24367dfda73f2d6ceab5c45fedd1a8
https://doi.org/10.1002/jps.20709
https://doi.org/10.1002/jps.20709
Autor:
Norma Lindsey Buchanan, Kevin J. Edgar, Charles Michael Buchanan, Jessica Dee Posey-Dowty, Juanelle Little Lambert, Michael G. Ramsey, Michael F. Wempe
Publikováno v:
Journal of Pharmaceutical Sciences. 95:2246-2255
The solubility and dissolution of tamoxifen base and tamoxifen citrate with and without hydroxybutenyl‐β‐cyclodextrin (HBenBCD) in aqueous and organic media were examined. The solubility of tamoxifen was greatly enhanced by complexation with HBe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e3da3348206b09a289bac7b89b6d8a
https://doi.org/10.1002/jps.20710
https://doi.org/10.1002/jps.20710
Publikováno v:
Cellulose. 14:35-47
The solubilities of voriconazole, ketoconazole, and clotrimazole with and without hydroxybutenyl-β-cyclodextrin (HBenBCD) in aqueous media were examined. The solubility of these antifungal drugs was significantly improved by complexation with HBenBC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a85e46e1e1a091733fad41c1a289cd8
https://doi.org/10.1007/s10570-006-9076-x
https://doi.org/10.1007/s10570-006-9076-x
Publikováno v:
Catalysis Today. 49:431-440
A surprisingly efficient carbonylation of ethylene to yield propionic anhydride and propionic acid using halide promoted Mo(CO)6 catalysts has been recently reported in the literature. Although the earlier report included detailed kinetics and a uniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34f1760fc5a694a209a513d10882de3
https://doi.org/10.1016/s0920-5861(98)00457-x
https://doi.org/10.1016/s0920-5861(98)00457-x
Autor:
Charles Michael Buchanan, Peter J. Rice, Norma Lindsey Buchanan, Kevin J. Edgar, Michael G. Ramsey, Michael F. Wempe, Jennifer S Skotty, Gregory Hanley
Publikováno v:
The Journal of pharmacy and pharmacology. 59(6)
Cyclodextrins (CDs) are one of the most successful solutions to the problem of poor drug solubility. In this study, we examined the in-vitro effects of three CDs on the solubility of letrozole, a breast cancer drug that is practically insoluble in wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73169a29f19ccce3fcecab23823826b6
https://pubmed.ncbi.nlm.nih.gov/17637172
https://pubmed.ncbi.nlm.nih.gov/17637172
Autor:
Charles Michael Buchanan, Michael F. Wempe, Kevin J. Edgar, Vincent J. Wacher, Norma Lindsey Buchanan, Karen M. Ruble, Michael G. Ramsey
Publikováno v:
International journal of pharmaceutics. 346(1-2)
Raloxifene is a highly insoluble, highly metabolized serum estrogen receptor modulator approved for use in the treatment of osteoporosis. Hydroxybutenyl-beta-cyclodextrin (HBenBCD) is a novel solubility enhancer previously demonstrated to increase th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e214bd767c37aeb1984fc6e261088cb
https://pubmed.ncbi.nlm.nih.gov/17644287
https://pubmed.ncbi.nlm.nih.gov/17644287