Výsledky vyhledávání - "Norma J. Johnson"

Biochemical Modulation of 5-Bromo-2'-deoxyuridine and 5-Iodo-2'-deoxyuridine Incorporation Into DNA in VX2 Tumor-Bearing Rabbits

Autor: Philip L. Stetson, Norma J. Johnson, Zhaomin Yang, James A. Knol, Patricia Terrio, William D. Ensminger, Daniel P. Normolle, Conrad A. Knutsen, Ermelinda Sakmar, Diane M. Prieskorn

Publikováno v: JNCI Journal of the National Cancer Institute. 83:1659-1667

The thymidine analogues 5-bromo-2'-deoxyuridine (Brd-Urd) and 5-iodo-2'-deoxyuridine (IdUrd) compete with thymidine for incorporation into the DNA of replicating cells. This incorporation results in radiosensitizing effects which are directly related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed231a628d2addda24e3efad614eee62
https://doi.org/10.1093/jnci/83.22.1659

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Home rehabilitation for chronic obstructive pulmonary disease: A physical and occupational therapy approach

Autor: Norma J. Johnson, Doreen Grindler

Publikováno v: Journal of Home Health Care Practice. 2:19-43

The rehabilitation of the pulmonary patient in the home care setting is interdisciplinary. In this article, the core team consists of the physical and the occupational therapists. The team may be altered by the patient's needs. The authors present a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::472707dc30f868bee15ff7387e745d0b
https://doi.org/10.1177/108482239000200205

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Steady-State Arterial and Hepatic Venous Plasma Concentrations of 5-Bromo-2′-Deoxyuridine and 5-Iodo-2#x2032;-Deoxyuridine in Animals — Drugs Which Are Subject to Both Splanchnic and Extra-Splanchnic Elimination

Autor: Patricia Terrio, Derek A. Ganes, James A. Knol, Zhaomin Yang, Suzette C. Walker-Andrews, John G. Wagner, William D. Ensminger, Philip L. Stetson, Norma J. Johnson, Diane M. Prieskorn, James C. Andrews, Conrad A. Knutsen

Publikováno v: Selective Cancer Therapeutics. 5:193-203

We have previously shown that 5-fluorouracil (FUra) in humans obeys Michaelis-Menten elimination kinetics. In this article we show that the related bromine and iodine-containing analogs in animals obey similar kinetics. Steady-state arterial (CssA) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::473ae44fd4c8e309dc93a5ac451aa04c
https://doi.org/10.1089/sct.1989.5.193

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5-bromo-2′-deoxyuridine incorporation into DNA in hepatic VX2 tumor-bearing rabbits

Autor: Philip L. Stetson, James A. Knol, John G. Wagner, Patricia Terrio, Diane M. Prieskorn, Conrad A. Knutsen, Zhaomin Yang, William D. Ensminger, Norma J. Johnson

Publikováno v: Journal of Surgical Research. 47:112-116

The halogenated pyrimidine 5-bromo-2'-deoxyuridine (BrdUrd) possesses both radiosensitizing and antimetabolite effects through its incorporation as a thymidine analog in replicating DNA. To evaluate the regional advantage for treatment of hepatic mal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc86a72d90a1d10830840ae531ce624
https://doi.org/10.1016/0022-4804(89)90072-3

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Analysis of bromodeoxyuridine incorporation into DNA: Comparison of gas chromatographic/mass spectrometric, CsCl gradient sedimentation, and specific radioactivity methods

Autor: Norma J. Johnson, William D. Ensminger, Matthew G. Kott, Jonathan Maybaum, Philip L. Stetson

Publikováno v: Analytical Biochemistry. 161:164-171

A sensitive new method for the quantitation of 5-bromodeoxyuridine (BrdUrd) incorporated into DNA by GC/MS analysis of enzymatically released Thy and bromouracil (BrUra) is presented. The hydrolysis procedure was characterized and found to give unifo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0cc0fe25aaffe93a25066fa136cda27
https://doi.org/10.1016/0003-2697(87)90667-1

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