Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Norma H. Mahle"'
Development of Monoclonal Antibodies to the Malondialdehyde−Deoxyguanosine Adduct, Pyrimidopurinone1
Autor:
Norma H. Mahle, Naomi Eliezer, Lawrence J. Marnett, Cynthia L. Sevilla, Shawn M. O'Hara, Ryan J. Miller, Munetaka Nokubo, Adam Uzieblo, Carol A. Rouzer
Publikováno v:
Chemical Research in Toxicology. 10:172-180
Malondialdehyde (MDA), an endogenous product of lipid peroxidation and prostaglandin biosynthesis, is mutagenic in bacterial and mammalian cells and carcinogenic in rats. In order to determine whether MDA-modified bases are formed in nucleic acids in