Influence of sphingomyelin metabolism during epithelial-mesenchymal transition associated with aging in the renal papilla

Autor: Yamila Romina Brandán, Nicolás Octavio Favale, Lucila Gisele Pescio, Bruno Jaime Santacreu, Edith del Valle Guaytima, Norma B. Sterin‐Speziale, María Gabriela Márquez

Publikováno v: Journal of cellular physiologyREFERENCES. 237(10)

The renal collecting ducts (CD) are formed by a fully differentiated epithelium, and their tissue organization and function require the presence of mature cell adhesion structures. In certain circumstances, the cells can undergo de-differentiation by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf1f197ac22dcba7d21e30b474f4d4e
https://pubmed.ncbi.nlm.nih.gov/35908199

Apoptotic cell extrusion depends on single-cell synthesis of sphingosine-1-phosphate by sphingosine kinase 2

Autor: Norma B. Sterin-Speziale, Nicolás Octavio Favale, Lucila Gisele Pescio, Daniela Judith Romero, Bruno Jaime Santacreu, Estefanía Tarallo

Publikováno v: Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(4)

Collecting duct cells are physiologically subject to the hypertonic environment of the kidney. This condition is necessary for kidney maturation and function but represents a stress condition that requires active strategies to ensure epithelial integ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94ba4e56d208b032cc254db221101ef
https://pubmed.ncbi.nlm.nih.gov/33454434

Bradykinin mediates the association of collecting duct cells to form migratory colonies, through B2 receptor activation

Autor: Edith del Valle Guaytima, Norma B. Sterin-Speziale, Nicolás Octavio Favale, Yamila Romina Brandán, María Gabriela Márquez, Bruno Jaime Santacreu

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

It is known that bradykinin (BK) B2 receptor (B2R) is expressed in the collecting duct (CD) cells of the newborn rat kidney, but little is known about its role during early postnatal life. Therefore, we hypothesize that BK could participate in the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b80d5e4787083c8afa7b17876ad4e3f
http://doi.wiley.com/10.1002/jcp.26472

Changes in ceramide metabolism are essential in Madin-Darby canine kidney cell differentiation

Autor: Lucila Gisele Pescio, Nicolás Octavio Favale, Norma B. Sterin-Speziale, Bruno Jaime Santacreu, Vanina Gisela Lopez, Daniela Judith Romero, Carlos Humberto Pavan

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of Lipid Research, Vol 58, Iss 7, Pp 1428-1438 (2017)

Ceramides and complex sphingolipids with defined acyl-chain lengths play important roles in numerous cell processes. Six ceramide synthase isoenzymes (CerS1-6) are the key enzymes responsible for the production of the diversity of molecular species.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc24daf65828dfdbb72d6aff66de825
http://www.jlr.org/lookup/doi/10.1194/jlr.M076349

Glycosphingolipid synthesis is essential for MDCK cell differentiation

Autor: Lucila Gisele Pescio, María Eugenia González Márquez, Nicolás Octavio Favale, Norma B. Sterin-Speziale

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1821:884-894

Glycosphingolipids (GSLs), which are highly concentrated at the apical membrane of polarized epithelial cells, are key components of cell membranes and are involved in a large number of processes. Here, we investigated the ability of hypertonicity (h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4c943d35f999f3e3b6d97b162c485d
https://doi.org/10.1016/j.bbalip.2012.02.009