Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia

Autor: Thomas D. Cardaci, Brandon N. VanderVeen, Brooke M. Bullard, Sierra J. McDonald, Christian A. Unger, Reilly T. Enos, Daping Fan, Kandy T. Velázquez, Norma Frizzell, Espen E. Spangenburg, E. Angela Murphy

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 1, Pp 124-137 (2024)

Abstract Background More than 650 million people are obese (BMI > 30) worldwide, which increases their risk for several metabolic diseases and cancer. While cachexia and obesity are at opposite ends of the weight spectrum, leading many to suggest a p

Externí odkaz: https://doaj.org/article/8e58be7d41294061abe0faa6c1ffb64b

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

Autor: Julie Adam, Reshma Ramracheya, Margarita V. Chibalina, Nicola Ternette, Alexander Hamilton, Andrei I. Tarasov, Quan Zhang, Eduardo Rebelato, Nils J.G. Rorsman, Rafael Martín-del-Río, Amy Lewis, Gizem Özkan, Hyun Woong Do, Peter Spégel, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Benedikt M. Kessler, Christopher W. Pugh, Jorge Tamarit-Rodriguez, Hindrik Mulder, Anne Clark, Norma Frizzell, Tomoyoshi Soga, Frances M. Ashcroft, Andrew Silver, Patrick J. Pollard, Patrik Rorsman

Publikováno v: Cell Reports, Vol 20, Iss 13, Pp 3135-3148 (2017)

We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intoleran

Externí odkaz: https://doaj.org/article/05d52d7c48f340449106e32e0dd4ebf7

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Autor: Alexander Hooftman, Christian G. Peace, Dylan G. Ryan, Emily A. Day, Ming Yang, Anne F. McGettrick, Maureen Yin, Erica N. Montano, Lihong Huo, Juliana E. Toller-Kawahisa, Vincent Zecchini, Tristram A. J. Ryan, Alfonso Bolado-Carrancio, Alva M. Casey, Hiran A. Prag, Ana S. H. Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J. Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander Von Kriegsheim, Michael P. Murphy, Caroline Jefferies, Christian Frezza, Luke A. J. O’Neill

Publikováno v: Hooftman, A, G. Peace, C, G. Ryan, D, A. Day, E, Yang, M, F. McGettrick, A, Yin, M, N. Montano, E, Huo, L, E. Toller-Kawahisa, J, Zecchini, V, A. J. Ryan, T, Bolado Carrancio, A, M. Casey, A, A. Prag, H, S.H. Costa, A, De Los Santos, G, Ishimori, M, J. Wallace, D, Venuturupalli, S, Nikitopoulou, E, Frizzell, N, Johansson, C, von Kriegsheim, A, P. Murphy, M, Jefferies, C, Frezza, C & A.J. O'Neill, L 2023, ' Macrophage fumarate hydratase restrains mtRNA-mediated interferon production ', Nature, vol. 615, pp. 490-498 . https://doi.org/10.1038/s41586-023-05720-6

Metabolic rewiring underlies the effector functions of macrophages 1–3, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory aspartate–arginin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1440c30dd8894932c61643e40d2cc0cc
http://hdl.handle.net/10044/1/104575

Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte

Autor: Allison M. Manuel, Margaret T. Dorn, Norma Frizzell, Gerardo G. Piroli, Ross M. Tanis, Michael D. Walla

Publikováno v: Free Radic Biol Med

C/EBP homologous protein (CHOP) is a transcription factor that is elevated in adipose tissue across many models of diabetes and metabolic stress. Although increased CHOP levels are associated with the terminal response to endoplasmic reticulum stress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a336dd030d9891192d8c0039760ede
https://doi.org/10.1016/j.freeradbiomed.2019.12.037

Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization

Autor: Jingtian Wang, Norma Frizzell, Michael D. Walla, Liang Shi, Allison M. Manuel, Ashley Galloway, Gerardo G. Piroli, Scott A. Lanci, Pavel I. Ortinski, Tulsi Patel, Deanna S. Smith

Publikováno v: Molecular & Cellular Proteomics. 18:504-519

The fumarate ester dimethyl fumarate (DMF) has been introduced recently as a treatment for relapsing remitting multiple sclerosis (RRMS), a chronic inflammatory condition that results in neuronal demyelination and axonal loss. DMF is known to act by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5878f378a1b60e446528417f6795b7
https://doi.org/10.1074/mcp.ra118.000922