Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Noriyuki Kurose"'
Publikováno v:
Organic Process Research & Development. 24:1095-1103
This work presents a guideline for managing process safety under continuous flow conditions. In our previous work, we developed a Grignard reaction for use under such conditions. This reaction was ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d89592bb64a15e2cfba528bad8bf5699
https://doi.org/10.1021/acs.oprd.0c00109
https://doi.org/10.1021/acs.oprd.0c00109
Publikováno v:
Organic Process Research & Development. 24:405-414
This work presents a case study of process development using continuous flow synthesis. In developing a process for manufacturing drug substances in batch reactors, we unexpectedly obtained a signi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f02071b172f0515543887ad884565bab
https://doi.org/10.1021/acs.oprd.9b00515
https://doi.org/10.1021/acs.oprd.9b00515
Autor:
Hiroyuki Kai, Takuya Shintani, Ryouko Sekimoto, Erika Kasai, Yasuhiko Fujii, Yusuke Ichihashi, Kazuhisa Minami, Noriyuki Kurose, Murakami Yuki, Naohiro Itoh, Osamu Yoshida, Shunji Shinohara, Hirai Keiichiro, Naohiro Onodera, Sosuke Yoneda, Takayuki Kameyma, Hiroko Ogawa, Kenichiroh Nakamura, Tohru Horiguchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 52:128384
In previous work, we discovered a lead compound and conducted initial SAR studies on a novel series of dioxotriazines to identify the compound as one of the P2X3 receptor antagonists. This compound showed high P2X3 receptor selectivity and a strong a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85629ea1876e5310b94d29621738018
https://doi.org/10.1016/j.bmcl.2021.128384
https://doi.org/10.1016/j.bmcl.2021.128384
Autor:
Yasuyoshi Iso, Harrie J.M. Gijsen, Gaku Sakaguchi, Shuhei Yoshida, Deborah Dhuyvetter, Yasunori Mitsuoka, Shigeru Ando, Shuichi Hiroyama, Yoshinori Yamano, Kiyotaka Koyabu, Moriyasu Masui, Herman Borghys, Yasuto Kido, Noriyuki Kurose, Motoko Hosono, Masayoshi Ogawa, Hisanori Ito, Chie Unemura, Shuichi Ohnishi, Takahiko Yamamoto, Ken-ichi Kusakabe, Kazuo Komano, Hirofumi Miyajima, Tamio Fukushima, Kouki Fuchino
Publikováno v:
Journal of medicinal chemistry. 61(12)
Accumulation of Aβ peptides is a hallmark of Alzheimer’s disease (AD) and is considered a causal factor in the pathogenesis of AD. β-Secretase (BACE1) is a key enzyme responsible for producing Aβ peptides, and thus agents that inhibit BACE1 shou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601e930231423ee6e8972d7b96fcf279
https://pubmed.ncbi.nlm.nih.gov/29733614
https://pubmed.ncbi.nlm.nih.gov/29733614
Autor:
Yasuyoshi Iso, Shintani Takuya, John J. Engel, Akira Kato, Jianming Yu, Tsuyoshi Hasegawa, Toshiyuki Asaki, Yoshitaka Yamaguchi, Naoki Tsuno, Laykea Tafesse, Chiyou Ni, Noriyuki Kurose, Kevin C. Brown, Toshiyuki Kanemasa, Gang Wu, Manjunath S. Shet, Yuka Iwamoto, Aniket Patel, Donald J. Kyle, Xiaoming Zhou
Publikováno v:
Journal of Medicinal Chemistry. 57:6781-6794
A series of novel tetrahydropyridinecarboxamide TRPV1 antagonists were prepared and evaluated in an effort to optimize properties of previously described lead compounds from piperazinecarboxamide series. The compounds were evaluated for their ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e9a80de5389c83676a37a8b92fce8dc
https://doi.org/10.1021/jm500818a
https://doi.org/10.1021/jm500818a
Autor:
Takao Shishido, Minako Mikamiyama-Iwata, Yoshiyuki Taoda, Tomokazu Yoshinaga, Ryu Yoshida, Naoko Kurihara, Naoyuki Suzuki, Kenji Morimoto, Noriyuki Kurose, Masayoshi Miyagawa, Hidenori Mikamiyama, Makoto Kawai, Kazunari Hattori, Kenji Tomita, Chika Takahashi-Kageyama, Toshiyuki Akiyama, Kenji Matsuo, Kenji Takaya, Akihiko Sato
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(19)
We report the discovery of a novel series of influenza Cap-dependent EndoNuclease (CEN) inhibitors based on the 4-pyridone-carboxylic acid (PYXA) scaffold, which were found from our chelate library. Our SAR research revealed the lipophilic domain to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69232b20f8a66fc4e31959854f6ec6a1
https://pubmed.ncbi.nlm.nih.gov/27568084
https://pubmed.ncbi.nlm.nih.gov/27568084
Autor:
Brian A. Johns, Takashi Kawasuji, Jason G. Weatherhead, Eric E. Boros, James B. Thompson, Edward P. Garvey, Scott A. Foster, Jerry L. Jeffrey, Wayne H. Miller, Noriyuki Kurose, Kenichi Matsumura, Tamio Fujiwara
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6461-6464
A series of naphthyridinone HIV-1 integrase strand-transfer inhibitors have been designed based on a psdeudo-C2 symmetry element present in the two-metal chelation pharmacophore. A combination of two distinct inhibitor binding modes resulted in poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543859790f45db50300fc75d2aaf2ab7
https://doi.org/10.1016/j.bmcl.2011.08.082
https://doi.org/10.1016/j.bmcl.2011.08.082
Autor:
Elie A. Tabet, Greg A. Erickson, Matthew A. Toczko, James B. Thompson, Matthew J. Sharp, Brian A. Johns, Eric E. Boros, Noriyuki Kurose, Svetlana A. Burova, Cecilia S. Koble
Publikováno v:
Organic Process Research & Development. 11:899-902
A scaleable synthesis of methyl 3-amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate (1b), starting from 5-bromo-2-methoxypyridine (8) and 4-fluorobenzaldehyde (9), is described. Key steps in the process include lithium–bromine exchange of 8, addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc1aacf6c3fd638906bbf03201337d4
https://doi.org/10.1021/op7001326
https://doi.org/10.1021/op7001326
Autor:
Laykea, Tafesse, Toshiyuki, Kanemasa, Noriyuki, Kurose, Jianming, Yu, Toshiyuki, Asaki, Gang, Wu, Yuka, Iwamoto, Yoshitaka, Yamaguchi, Chiyou, Ni, John, Engel, Naoki, Tsuno, Aniket, Patel, Xiaoming, Zhou, Takuya, Shintani, Kevin, Brown, Tsuyoshi, Hasegawa, Manjunath, Shet, Yasuyoshi, Iso, Akira, Kato, Donald J, Kyle
Publikováno v:
Journal of medicinal chemistry. 57(15)
A series of novel tetrahydropyridinecarboxamide TRPV1 antagonists were prepared and evaluated in an effort to optimize properties of previously described lead compounds from piperazinecarboxamide series. The compounds were evaluated for their ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6269cef57a4f6ded6961c15e98312cd
https://pubmed.ncbi.nlm.nih.gov/25057800
https://pubmed.ncbi.nlm.nih.gov/25057800
Publikováno v:
ResearcherID
An overview of the recent studies on the asymmetric syntheses, stereochemical studies, reactions and applications of chiral chalcogenuranes is described. Chiral chalcogenuranes, including halooxachalcogenuranes and spirochalcogenuranes, have been syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1c6a85bc83e83a9db1a7798aa7cbb8
https://doi.org/10.5059/yukigoseikyokaishi.57.587
https://doi.org/10.5059/yukigoseikyokaishi.57.587