Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Noriyuki Koyama"'
Publikováno v:
Fundamental Toxicological Sciences. 9:71-83
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a6739c0ae4bf2381520709e210761c6
https://doi.org/10.2131/fts.9.71
https://doi.org/10.2131/fts.9.71
Autor:
Tomohide Tamura, Noriyuki Koyama, Kazuto Nishio, Fumiaki Koizumi, Taizo Hirata, Yutaka Fujiwara, Hiroshi Nokihara, Yasuhide Yamada, Noboru Yamamoto, Kazuhiko Yamada
Purpose: E7080, an oral multitargeted receptor tyrosine kinase inhibitor, has antiangiogenic and antitumor activity. This Phase I study investigated maximum tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetics (PK), pharmacodynamics (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804fd00a46698f08eca12c525c105d63
https://doi.org/10.1158/1078-0432.c.6519344
https://doi.org/10.1158/1078-0432.c.6519344
Autor:
Tomohide Tamura, Noriyuki Koyama, Kazuto Nishio, Fumiaki Koizumi, Taizo Hirata, Yutaka Fujiwara, Hiroshi Nokihara, Yasuhide Yamada, Noboru Yamamoto, Kazuhiko Yamada
PDF file - 279K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8e6dd49c6513cbd7542598e91fa896
https://doi.org/10.1158/1078-0432.22442672.v1
https://doi.org/10.1158/1078-0432.22442672.v1
Publikováno v:
Neuroscience Research. 173:99-105
Sleep stage scoring is important to determine sleep structure in preclinical and clinical research. The aim of this study was to develop an automatic sleep stage classification system for mice with a new deep neural network algorithm. For the purpose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d512a70cd01589b040f257126fe3c8d2
https://doi.org/10.1016/j.neures.2021.07.003
https://doi.org/10.1016/j.neures.2021.07.003
Autor:
Eiji Fukunaga, Takuma Miura, Keishi Akada, Keiichi Fujiwara, Noriyuki Koyama, Ken Aoshima, Yuji Miura
Publikováno v:
Current Medical Research and Opinion. 37:1171-1178
The aim was to identify the characteristics and treatment patterns of early and advanced stage endometrial cancer patients using real-world data.Patients' data extracted from a Japanese health insurance claims database were analyzed.Of the 12,449 end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38bfb7e379592679ef9557e504009ce
https://doi.org/10.1080/03007995.2021.1903847
https://doi.org/10.1080/03007995.2021.1903847
Autor:
Hidetaka Hiyama, Naoya Arichika, Minoru Okada, Noriyuki Koyama, Tomonori Tahara, Junpei Haruta
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. :JPET-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f55370abb265814b7dbba0813d8afe4c
https://doi.org/10.1124/jpet.123.001609
https://doi.org/10.1124/jpet.123.001609
Publikováno v:
Folia Pharmacologica Japonica. 156:114-119
Orexin receptor antagonists have been approved for insomnia, and the insomnia pharmacotherapy is being greatly progressed. Orexin is a neuropeptide produced in the lateral hypothalamic area, and its physiological role has been suggested to be a key m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f08b5f41d71b13caee8533023c580547
https://doi.org/10.1254/fpj.20093
https://doi.org/10.1254/fpj.20093
Publikováno v:
Current medical research and opinion. 38(8)
To clarify the status of insomnia and depression and the prescription of sleeping pills in hepatocellular carcinoma (HCC) patients before and after HCC diagnosis and treatment.Patients' data from a Japanese health insurance claims database were analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9137754955d05f32342fbbe3e671915
https://pubmed.ncbi.nlm.nih.gov/35608320
https://pubmed.ncbi.nlm.nih.gov/35608320
Autor:
Noriyuki Koyama, Takashi Sawada, Akira Kato, Toshitaka Akatsuka, Asai Tomohide, Satoyoshi Yamashita, Kiwamu Okita
Publikováno v:
World Journal of Gastroenterology
Background The prognosis of hepatocellular carcinoma (HCC) patients remains poor despite advances in treatment modalities and diagnosis. It is important to identify useful markers for the early detection of HCC in patients. Preneoplastic antigen (PNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508bbb54eb47c56af1ef5d8c3b58a24a
https://doi.org/10.3748/wjg.v26.i13.1463
https://doi.org/10.3748/wjg.v26.i13.1463
Autor:
Tatsuo Watanabe, Noriyuki Koyama
Publikováno v:
Folia Pharmacologica Japonica. 153:242-248
Lenvatinib is an oral multikinase inhibitor that targets VEGF receptors 1-3, FGF receptors 1-4, PDGF receptor α, RET, and KIT. The preclinical studies of lenvatinib for hepatocellular carcinoma (HCC) suggest that lenvatinib exerts the potent antitum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce671839e33d97ecbd66e9383b1465b6
https://doi.org/10.1254/fpj.153.242
https://doi.org/10.1254/fpj.153.242