Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Noriyasu Nishimura"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2791-2795
In order to investigate the effect of the fixation of the orientations of the two long chains, three types of novel derivatives of scavenger receptor inhibitor 1 were synthesized, and their biological activities were evaluated. Among the novel deriva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcba9138236064e76bb39a87ecd959fe
https://doi.org/10.1016/j.bmcl.2004.03.082
https://doi.org/10.1016/j.bmcl.2004.03.082
Autor:
Naohiko Ueno, Juei-Tang Cheng, Toshihiro Kaga, Rika Dobashi, Yasuo Morimoto, Akio Inui, Minoru Okita, Akihiro Asakawa, I-Min Liu, Mineko Fujimiya, Masato Kasuga, Noriyasu Nishimura
Publikováno v:
Diabetes. 50:1206-1210
Neuropeptide Y (NPY), one of the most abundant peptide transmitters in the mammalian brain, is assumed to play an important role in feeding and body weight regulation. However, there is little genetic evidence that overexpression or knockout of the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46ea2f3e4f69fc91d9d0dc278e5d412
https://doi.org/10.2337/diabetes.50.5.1206
https://doi.org/10.2337/diabetes.50.5.1206
Publikováno v:
British Journal of Pharmacology. 127:1846-1850
We investigated protective effects of KB-R7943, a Na+/Ca2+ exchange (NCX) inhibitor, on ouabain-induced tonotropy and arrhythmias in isolated whole atria and ouabain-induced changes in electrocardiogram (ECG) in the guinea-pig. KB-R7943 (10 and 30 μ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e56eb40ab9c39a33689b465387d67ae
https://doi.org/10.1038/sj.bjp.0702740
https://doi.org/10.1038/sj.bjp.0702740
Autor:
Takeshi Imanishi, Tatsuhiko Kodama, Toshiki Tanaka, Koji Yamamoto, Kazuo Suzuki, Noriyasu Nishimura, Takefumi Doi
Publikováno v:
FEBS Letters. 414:182-186
Scavenger receptors bind modified low-density lipoproteins (LDL) on a collagen-like domain which possesses a lysine cluster at the car☐y end. We previously constructed a receptor model peptide containing the lysine cluster. In the present study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053a9778403e8c1fb7d0eb470accda08
https://doi.org/10.1016/s0014-5793(97)01006-5
https://doi.org/10.1016/s0014-5793(97)01006-5
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:2005-2010
In our series of studies on potassium channel openers, several thienylcyanoguanidine derivatives were synthesized and evaluated for smooth muscle relaxation activity in vitro. Among the newly synthesized compounds, N-cyano-N'-(5-cyano-3-thienyl)-N"-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee0b852f06357bb5668a44fe7b01df1
https://doi.org/10.1248/cpb.45.2005
https://doi.org/10.1248/cpb.45.2005
Autor:
Kazuya Yoshizumi, Kohichiro Yoshino, Tominori Morita, Takayuki Sukamoto, Shoji Ikeda, Noriyasu Nishimura, Katsumi Goto
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:2042-2050
3, 5-Di-substituted phenylcyanoguanidine derivatives with halogen, cyano, and/or nitro groups at the 3- and 5-positions of the benzene ring exhibited very strong smooth muscle relaxation activity in vitro, as compared to pinacidil. Among them, N-(3-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965b44074d24d6beecefb648895845e1
https://doi.org/10.1248/cpb.44.2042
https://doi.org/10.1248/cpb.44.2042
Autor:
Shoji Ikeda, Noriyasu Nishimura, K. Goto, T. Sukamoto, Kazuya Yoshiizumi, Kohichiro Yoshino, Tominori Morita
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2472b01429168c2afe8af7b7b7f0e60f
https://doi.org/10.1002/chin.199721106
https://doi.org/10.1002/chin.199721106
Publikováno v:
ChemInform. 29
In our series of studies on potassium channel openers, several thienylcyanoguanidine derivatives were synthesized and evaluated for smooth muscle relaxation activity in vitro. Among the newly synthesized compounds, N-cyano-N'-(5-cyano-3-thienyl)-N"-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1cb14626228e8cfbcde254b28cca3c6
https://doi.org/10.1002/chin.199823112
https://doi.org/10.1002/chin.199823112
Publikováno v:
Bioorganicmedicinal chemistry. 10(8)
Scavenger receptors have been proven to be implicated in the formation of atherosclerotic lesions. A series of novel derivatives of sulfatides were synthesized, and their inhibitory activities against incorporation of DiI-acetyl-LDL into macrophages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ea729c567341dedaf0ef93a09b2a66
https://pubmed.ncbi.nlm.nih.gov/12057634
https://pubmed.ncbi.nlm.nih.gov/12057634
Autor:
Jun An, Akira Yamamoto, Dong Xan Hui, Taku Yamamura, Mariko Harada-Shiba, Yasuko Miyake, Ryo Sugano, Noriyasu Nishimura
Publikováno v:
Lipoprotein Metabolism and Atherogenesis ISBN: 9784431684268
We investigate the expression of CD36 in THP-1 cells and the THP-1 subtype (sTHP-1). The sTHP-1 cells accumulated esterified cholesterol after incubation with oxidized LDL (Ox-LDL), but not after incubation with acetylated LDL (Ac-LDL). The specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64a9af285409c9af59d1a11e0883533f
https://doi.org/10.1007/978-4-431-68424-4_49
https://doi.org/10.1007/978-4-431-68424-4_49
