Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Noritaka Tanaka"'
Autor:
Noritaka Tanaka, Hikari Okada, Kiyoshi Yamaguchi, Masahide Seki, Daisuke Matsubara, Noriko Gotoh, Yutaka Suzuki, Yoichi Furukawa, Taro Yamashita, Jun-ichiro Inoue, Shuichi Kaneko, Takeharu Sakamoto
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-12 (2023)
Abstract Given the lack of therapeutic targets, the conventional approach for managing triple-negative breast cancer (TNBC) involves the utilization of cytotoxic chemotherapeutic agents. However, most TNBCs acquire resistance to chemotherapy, thereby
Externí odkaz:
https://doaj.org/article/bb2d8ae7e71c4a039d982e2c5ef19671
Autor:
Junichi Ikeda, Chisato Ohe, Noritaka Tanaka, Takashi Yoshida, Ryoichi Saito, Naho Atsumi, Takashi Kobayashi, Hidefumi Kinoshita, Koji Tsuta, Takeharu Sakamoto
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 1, Pp n/a-n/a (2023)
Abstract Background Although the introduction of multiple agents targeting immune and oncogenic signaling pathways has substantially changed the treatment strategies for urothelial carcinoma (UC), these drugs still have some limitations, such as adve
Externí odkaz:
https://doaj.org/article/e111d7759be94d1db65305cfa39966d1
Autor:
Noritaka Tanaka, Takeharu Sakamoto
Publikováno v:
Cells, Vol 12, Iss 17, p 2187 (2023)
Membrane type1-matrix metalloproteinase (MT1-MMP) is a member of metalloproteinases that is tethered to the transmembrane. Its major function in cancer progression is to directly degrade the extracellular matrix components, which are mainly type I–
Externí odkaz:
https://doaj.org/article/7a9b41e1200e45bb9dae9e86b77b9a18
Autor:
Noritaka Tanaka, Takeharu Sakamoto
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 549 (2023)
Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that plays a crucial role in cells adapting to a low-oxygen environment by facilitating a switch from oxygen-dependent ATP production to glycolysis. Mediated by membrane type-1 matrix m
Externí odkaz:
https://doaj.org/article/961098cf801245d1bdb90df533e0da04
Autor:
Hiroyuki Seimiya, Yoshikazu Sugimoto, Naoya Fujita, Satoshi Nagayama, Ryohei Katayama, Masaaki Matsuura, Kento Nakata, Yukiko Muramatsu, Haruka Yoshida, Bo Gong, Aki Aoyama, Ayana Sato, Anna Mizutani, Tetsuo Mashima, Noritaka Tanaka
In most colorectal cancers, Wnt/β-catenin signaling is activated by loss-of-function mutations in the adenomatous polyposis coli (APC) gene and plays a critical role in tumorigenesis. Tankyrases poly(ADP-ribosyl)ate and destabilize Axins, a negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8058dabfd4016a1add46858c13f4ab3e
https://doi.org/10.1158/1535-7163.c.6538768
https://doi.org/10.1158/1535-7163.c.6538768
Autor:
Ryan B. Corcoran, Rebecca S. Heist, Aaron N. Hata, Liron Bar-Peled, Giulia Siravegna, Jochen K. Lennerz, Samuel J. Klempner, Justin F. Gainor, Dejan Juric, Islam Baiev, Mustafa Sakhi, Katerina A. Fella, Mohammed U. Syed, Alexa G. Michel, Lesli A. Kiedrowski, Junbing Zhang, Meagan B. Ryan, Chendi Li, Jessica J. Lin, Noritaka Tanaka
Mutant-selective KRASG12C inhibitors, such as MRTX849 (adagrasib) and AMG 510 (sotorasib), have demonstrated efficacy in KRASG12C-mutant cancers, including non–small cell lung cancer (NSCLC). However, mechanisms underlying clinical acquired resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6aa2acd4b997a9e54783ae8dd826d4
https://doi.org/10.1158/2159-8290.c.6549266
https://doi.org/10.1158/2159-8290.c.6549266
Autor:
Hiroyuki Seimiya, Yoshikazu Sugimoto, Naoya Fujita, Satoshi Nagayama, Ryohei Katayama, Masaaki Matsuura, Kento Nakata, Yukiko Muramatsu, Haruka Yoshida, Bo Gong, Aki Aoyama, Ayana Sato, Anna Mizutani, Tetsuo Mashima, Noritaka Tanaka
Supplementary Figure S1: Full scans of the immunoblots shown in Figs. 1C, 2A and 4A. Supplementary Figure S2: Basal expression of tankyrase, Axins, and β-catenin and intracellular localization of β-catenin in CRC cell lines used in this study. Supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae13bad0fba3f6dc4a70c7ff8b0ef43
https://doi.org/10.1158/1535-7163.22507726.v1
https://doi.org/10.1158/1535-7163.22507726.v1
Autor:
Hiroyuki Seimiya, Yoshikazu Sugimoto, Naoya Fujita, Satoshi Nagayama, Ryohei Katayama, Masaaki Matsuura, Kento Nakata, Yukiko Muramatsu, Haruka Yoshida, Bo Gong, Aki Aoyama, Ayana Sato, Anna Mizutani, Tetsuo Mashima, Noritaka Tanaka
Legends for Supplementary Figure S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c208e1d39930ee1ab90fbc4958f76a
https://doi.org/10.1158/1535-7163.22507732.v1
https://doi.org/10.1158/1535-7163.22507732.v1
Autor:
Hiroyuki Seimiya, Yoshikazu Sugimoto, Naoya Fujita, Satoshi Nagayama, Ryohei Katayama, Masaaki Matsuura, Kento Nakata, Yukiko Muramatsu, Haruka Yoshida, Bo Gong, Aki Aoyama, Ayana Sato, Anna Mizutani, Tetsuo Mashima, Noritaka Tanaka
Multiple regression analysis of tankyrase inhibitor sensitivities and genetic mutations in colorectal cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf039b732b086df7e454dda2d5cb49a
https://doi.org/10.1158/1535-7163.22507720.v1
https://doi.org/10.1158/1535-7163.22507720.v1
Autor:
Ryan B. Corcoran, Rebecca S. Heist, Aaron N. Hata, Liron Bar-Peled, Giulia Siravegna, Jochen K. Lennerz, Samuel J. Klempner, Justin F. Gainor, Dejan Juric, Islam Baiev, Mustafa Sakhi, Katerina A. Fella, Mohammed U. Syed, Alexa G. Michel, Lesli A. Kiedrowski, Junbing Zhang, Meagan B. Ryan, Chendi Li, Jessica J. Lin, Noritaka Tanaka
Supplementary Materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a96c09e6d29bcd6766cf1adc0dadec
https://doi.org/10.1158/2159-8290.22540040.v1
https://doi.org/10.1158/2159-8290.22540040.v1