Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Noritaka Saeki"'
Autor:
Hiroaki Kato, Noritaka Saeki, Matome Imai, Hiroshi Onji, Akiko Yano, Shuhei Yoshida, Tomohisa Sakaue, Toru Fujioka, Takashi Sugiyama, Yuuki Imai
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe incidence of endometrial cancer (EC) has been increasing worldwide. However, because there are limited chemotherapeutic options for the treatment of EC, the prognosis of advanced-stage EC is poor.MethodsGene expression profile dataset
Externí odkaz:
https://doaj.org/article/ccce4d2ccf184c8982c8d235e29d11a7
Autor:
Noritaka Saeki, Kazuki Inoue, Maky Ideta-Otsuka, Kunihiko Watamori, Shinichi Mizuki, Katsuto Takenaka, Katsuhide Igarashi, Hiromasa Miura, Shu Takeda, Yuuki Imai
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation with aberrant epigenetic alterations, eventually leading to joint destruction. However, the epigenetic regulatory mechanisms underlying RA pathogenesis remain largely unknown
Externí odkaz:
https://doaj.org/article/f1838a9b286847508d31911b8c6d40b6
Autor:
Noritaka Saeki, Yuuki Imai
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Macrophages adapt to microenvironments, and change metabolic status and functions to regulate inflammation and/or maintain homeostasis. In joint cavities, synovial macrophages (SM) and synovial fibroblasts (SF) maintain homeostasi
Externí odkaz:
https://doaj.org/article/192aaaa16e934711af643c05477e733d
Autor:
Iori Sakakibara, Yuta Yanagihara, Koichi Himori, Takashi Yamada, Hiroshi Sakai, Yuichiro Sawada, Hirotaka Takahashi, Noritaka Saeki, Hiroyuki Hirakawa, Atsushi Yokoyama, So-ichiro Fukada, Tatsuya Sawasaki, Yuuki Imai
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102303- (2021)
Summary: Androgens have a robust effect on skeletal muscles to increase muscle mass and strength. The molecular mechanism of androgen/androgen receptor (AR) action on muscle strength is still not well known, especially for the regulation of sarcomeri
Externí odkaz:
https://doaj.org/article/2679619e7a864ac0b4a329e480d4e59d
Publikováno v:
BMC Cell Biology, Vol 18, Iss 1, Pp 1-20 (2017)
Abstract Background Eph signaling is known to induce contrasting cell behaviors such as promoting and inhibiting cell adhesion/spreading by altering F-actin organization and influencing integrin activities. We have previously demonstrated that EphA2
Externí odkaz:
https://doaj.org/article/0b9611df3f514a3eb002285597c9f381
Autor:
Yuuki Imai, Noritaka Saeki
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5502eac8093f0e42640cb6b9931d18dc
https://doi.org/10.3791/65196
https://doi.org/10.3791/65196
Autor:
Takashi Saika, Noritaka Saeki, Yuuki Imai, So-ichiro Fukada, Hiroshi Sakai, Aoi Ikedo, Tadahiko Kikugawa, Hiroyuki Iio, Yuichiro Sawada, Shuhei Yoshida, Yuta Yanagihara
Publikováno v:
Biochemical and Biophysical Research Communications. 534:79-85
Epigenetic transcriptional regulation is essential for the differentiation of various types of cells, including skeletal muscle cells. DNA methyltransferase 1 (Dnmt1) is responsible for maintenance of DNA methylation patterns via cell division. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51af68e7bb42e10366af01892dc0dab
https://doi.org/10.1016/j.bbrc.2020.11.116
https://doi.org/10.1016/j.bbrc.2020.11.116
Autor:
Yuta Yanagihara, Balázs Győrffy, Hiroyuki Iio, Shuhei Yoshida, Yohei Miyagi, Takeshi Kishida, Noritaka Saeki, Aoi Ikedo, Takashi Saika, Iori Sakakibara, Tadahiko Kikugawa, Yoshiyasu Nakamura, Yoichiro Okubo, Yuuki Imai, Yuichiro Sawada
Publikováno v:
International Journal of Cancer. 146:1369-1382
The prognosis of patients with progressive prostate cancers that are hormone refractory and/or have bone metastasis is poor. Multiple therapeutic targets to improve prostate cancer patient survival have been investigated, including orphan GPCRs. In o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658e63e864b0ad19d7a731c519aee835
https://doi.org/10.1002/ijc.32554
https://doi.org/10.1002/ijc.32554
Autor:
Yuuki Imai, Watamori K, Mizuki S, Ideta-Otsuka M, Noritaka Saeki, Inoue K, Miura H, Igarashi K, Katsuto Takenaka
Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation with aberrant epigenetic alterations, eventually leading to joint destruction. However, epigenetic regulatory mechanisms underlying RA pathogenesis remain largely unknown. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c634b738299f704cefdb8786a119eaaa
https://doi.org/10.21203/rs.3.rs-293501/v1
https://doi.org/10.21203/rs.3.rs-293501/v1
Autor:
Tsutomu Kai, Atsushi Uematsu, Shigeki Higashiyama, Chikako Takahashi, Tatsuya Sawasaki, Shuhei Yoshida, Fuminori Tokunaga, Kouhei Shimizu, Kohki Kido, Yuta Yanagihara, Mamoru Honda, Hirotaka Takahashi, Masashi Maekawa, Yuuki Imai, Noritaka Saeki
Publikováno v:
J Biol Chem
The tumor suppressor CYLD is a deubiquitinating enzyme that suppresses polyubiquitin-dependent signaling pathways, including the proinflammatory and cell growth–promoting NF-κB pathway. Missense mutations in the CYLD gene are present in individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a163df856007f74dd6bb5690c5e7b6
https://europepmc.org/articles/PMC6755803/
https://europepmc.org/articles/PMC6755803/