Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Noritaka Koseki"'
Autor:
Hiroshi Endo, Kazuhiko Fukuda, Si Jing Chen, Koji Eto, Akira Sawaguchi, George J. Murphy, Naoshi Sugimoto, Hideya Seo, Noritaka Koseki, Yohei Nishi, Takuya Yamamoto, Hideki Hayashi, Akira Ohta, Kazuya Hashimoto, Akitsu Hotta
Publikováno v:
Blood Advances. 2:2262-2272
During maturation, megakaryocytes (MKs) express β1-tubulin (TUBB1) and rearrange their microtubule components to enlarge, form proplatelets, and eventually release platelets. The development of a platform to identify in vitro conditions that would e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0c65299254c6c99e67a5d06ce4ca9e
https://doi.org/10.1182/bloodadvances.2018019547
https://doi.org/10.1182/bloodadvances.2018019547
Autor:
Xiaojuan Xu, Shinichi Okuda, Masakazu Fukuda, Yoshihide Nakamura, Hiroyuki Kyushiki, Hironori Ishiguchi, Akihiro Hino, Wakako Murakami, Takako Maeda, Makoto Ono, Tetsuro Oda, Takeshi Yamamoto, Yoriomi Hamada, Noritaka Koseki, Shigeki Kobayashi, Masafumi Yano, Takuma Nanno, Takayoshi Kato, Go Fukui, Shigehiko Nishimura, Yoko Sufu
Publikováno v:
Heart rhythm. 14(1)
Background Calmodulin (CaM) is a key modulator of the channel gating function of the ryanodine receptor (RyR). Objective The purpose of this study was to investigate the pathogenic role of RyR-bound CaM in diastolic Ca 2+ leakage from the sarcoplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4cea27596e66ede4fbd9d89662ca7e
https://pubmed.ncbi.nlm.nih.gov/27771553
https://pubmed.ncbi.nlm.nih.gov/27771553
Autor:
Noriaki Ikemoto, Takeshi Suetomi, Wakako Murakami, Masahiro Doi, Masafumi Yano, Noritaka Koseki, Takehisa Susa, Masakazu Fukuda, Shinichi Okuda, Hiroyuki Kyushiki, Akihiro Hino, Shigeki Kobayashi, Makoto Ono, Masunori Matsuzaki, Takayoshi Kato, Takeshi Yamamoto
Publikováno v:
Cardiovascular Research. 96:433-443
Aims The channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, the involvement of CaM in aberrant Ca2+ release in diseased hearts remains unclear. Here, we investigated the pathogenic role of defective C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c214192a1063ad2a63e07061a65ff01
https://doi.org/10.1093/cvr/cvs271
https://doi.org/10.1093/cvr/cvs271
Autor:
Shinichi Okuda, Hiroyuki Kyushiki, Makoto Ono, Hiroki Tateishi, Masakazu Fukuda, Akihiro Hino, Wakako Murakami, Masafumi Yano, Shigeki Kobayashi, Noritaka Koseki, Takayoshi Kato, Takeshi Yamamoto, Shigehiko Nishimura, Testuro Oda
Publikováno v:
Biochemical and biophysical research communications. 448(1)
Aims Calmodulin (CaM) plays a key role in modulating channel gating in ryanodine receptor (RyR2). Here, we investigated (a) the pathogenic role of CaM in the channel disorder in CPVT and (b) the possibility of correcting the CPVT-linked channel disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180fb4eaed34091146cb9f56274b4dc7
https://pubmed.ncbi.nlm.nih.gov/24755079
https://pubmed.ncbi.nlm.nih.gov/24755079
Autor:
Hitoshi Uchinoumi, Takehisa Susa, Shigeki Kobayashi, Noriaki Ikemoto, Takeshi Suetomi, Takeshi Yamamoto, Noritaka Koseki, Masahiro Doi, Akihiro Hino, Hiroki Tateishi, Tetsuro Oda, Xiaojuan Xu, Masafumi Yano, Shinichi Okuda, Hiroyuki Kyushiki, Makoto Ono, Masunori Matsuzaki
Publikováno v:
Cardiovascular research. 87(4)
Aims Calmodulin (CaM) is well known to modulate the channel function of the cardiac ryanodine receptor (RyR2). However, the possible role of CaM on the aberrant Ca2+ release in diseased hearts remains unclear. In this study, we investigated the state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9898b6593682f331c0bf8d112cb1dbf
https://pubmed.ncbi.nlm.nih.gov/20587508
https://pubmed.ncbi.nlm.nih.gov/20587508
Autor:
Takeshi Suetomi, Shinichi Okuda, Noriaki Ikemoto, Hiroyuki Kyushiki, Mamoru Mochizuki, Makoto Ono, Xiaojuan Xu, Hiroki Tateishi, Takeshi Yamamoto, Masunori Matsuzaki, Noritaka Koseki, Hitoshi Uchinoumi, Masafumi Yano, Shigeki Kobayashi
ObjectivesWe sought to investigate the effect of dantrolene, a drug generally used to treat malignant hyperthermia, on the Ca2+release and cardiomyocyte function in failing hearts.BackgroundThe N-terminal (N: 1–600) and central (C: 2000–2500) dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06c70d275135b49c5d063649de0e5bb
https://europepmc.org/articles/PMC2764410/
https://europepmc.org/articles/PMC2764410/
