Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Noritaka Hashii"'
Autor:
Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Jun-ichi Furukawa, Noritaka Hashii, Akiko Ishii-Watabe, Ying Deng, Kazutoshi Matsushita, Tokiro Ishikawa, Yugoviandi P Mamahit, Yuta Maki, Yasuhiro Kajihara, Koichi Kato, Tetsuya Okada, Kazutoshi Mori
Publikováno v:
eLife, Vol 10 (2021)
Sequential mannose trimming of N-glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). We previo
Externí odkaz:
https://doaj.org/article/341ffd41c9234c5d998d7ae1195a462d
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Therapeutic immunoglobulin G (IgG) antibodies have comparatively long half-lives because the neonatal Fc receptor (FcRn) binds to the IgG Fc at acidic pH in the endosome and protects IgG from degradation. To further prolong the half-lives, amino acid
Externí odkaz:
https://doaj.org/article/a4170241beba40f7b616181ca0f672ce
Autor:
Hiroshi Yoshitake, Noritaka Hashii, Nana Kawasaki, Shuichiro Endo, Kenji Takamori, Akiko Hasegawa, Hiroshi Fujiwara, Yoshihiko Araki
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133784 (2015)
Ts4, an anti-sperm auto-monoclonal antibody, possesses immunoreactivity to the acrosomal region of mouse epididymal spermatozoa. In addition, the mAb shows specific immunoreactivity to reproduction-related regions such as testicular germ cells and ea
Externí odkaz:
https://doaj.org/article/3dc32a5a6ced43af90d77c069142d7eb
Autor:
Keiko Yabuno, Jyoji Morise, Yasuhiko Kizuka, Noritaka Hashii, Nana Kawasaki, Satoru Takahashi, Shinji Miyata, Tomomi Izumikawa, Hiroshi Kitagawa, Hiromu Takematsu, Shogo Oka
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144560 (2015)
Human natural killer-1 (HNK-1) carbohydrate (HSO3-3GlcAβ1-3Galβ1-4GlcNAc-R) is highly expressed in the brain and required for learning and neural plasticity. We previously demonstrated that expression of the HNK-1 epitope is mostly abolished in kno
Externí odkaz:
https://doaj.org/article/3b5ac93f9b60401093973e3b61d0fa91
Autor:
Yuri Miura, Noritaka Hashii, Hiroki Tsumoto, Daisuke Takakura, Yuki Ohta, Yukiko Abe, Yasumichi Arai, Nana Kawasaki, Nobuyoshi Hirose, Tamao Endo, SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians)
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142645 (2015)
An N-glycomic analysis of plasma proteins was performed in Japanese semisupercentenarians (SSCs) (mean 106.7 years), aged controls (mean 71.6 years), and young controls (mean 30.2 years) by liquid chromatography/mass spectrometry (LC/MS) using a grap
Externí odkaz:
https://doaj.org/article/eea60bd9f3984fe1acfb920c00c5c6de
Autor:
Hiroshi Asakura, Noritaka Hashii, Masashi Uema, Nana Kawasaki, Yoshiko Sugita-Konishi, Shizunobu Igimi, Shigeki Yamamoto
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70418 (2013)
Vitamin B6 (pyridoxal-5'-phosphate, PLP) is linked to a variety of biological functions in prokaryotes. Here, we report that the pdxA (putative 4-hydroxy-L-threonine phosphate dehydrogenase) gene plays a pivotal role in the PLP-dependent regulation o
Externí odkaz:
https://doaj.org/article/714006547a974059ab1cbbdf3f8b6eb7
Autor:
Noritaka Hashii, Akio Ishii-Watabe
Publikováno v:
Drug Delivery System. 36:342-352
Autor:
Takeshi Inoue, Ryo Shinnakasu, Chie Kawai, Hiromi Yamamoto, Shuhei Sakakibara, Chikako Ono, Yumi Itoh, Tommy Terooatea, Kazuo Yamashita, Toru Okamoto, Noritaka Hashii, Akiko Ishii-Watabe, Noah S. Butler, Yoshiharu Matsuura, Hisatake Matsumoto, Shinya Otsuka, Kei Hiraoka, Takanori Teshima, Masaaki Murakami, Tomohiro Kurosaki
Publikováno v:
The Journal of experimental medicine. 220(2)
In contrast to a second dose of the SARS-CoV-2 mRNA vaccine, a third dose elicits potent neutralizing activity against the Omicron variant. To address the underlying mechanism for this differential antibody response, we examined spike receptor-bindin
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(7)
In the development of therapeutic monoclonal antibodies (mAbs), it is essential to characterize the modifications causing structural heterogeneity because certain modifications are associated with safety and efficacy. However, the rapid structural an
Autor:
Noriko Inoue, Takuma Shigeyama, Hidehisa Tachiki, Takeru Yamaguchi, Kazuyuki Murata, Koji Arai, Shinichi Yamane, Mitsuhiko Kawabata, Mariko Yamaoka, Mio Nakatsuji, Takeshi Okuzono, Noritaka Hashii, Yoshiro Saito, Suguru Fukuda, Akiko Ishii-Watabe, Yoshimasa Enoki, Yoshiko Tousaka, Ryoya Goda
Publikováno v:
Bioanalysis. 13:265-276
Aim: We aimed to develop an easy, low-cost and versatile mass spectrometric method for the bioanalysis of a therapeutic monoclonal antibody (mAb) in human serum that employs peptide adsorption-controlled (PAC)-LC/MS using selected reaction monitoring