Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Noritaka, Kagaya"'
Autor:
Atina Rizkiya Choirunnisa, Kuga Arima, Yo Abe, Noritaka Kagaya, Kei Kudo, Hikaru Suenaga, Junko Hashimoto, Manabu Fujie, Noriyuki Satoh, Kazuo Shin-ya, Kenichi Matsuda, Toshiyuki Wakimoto
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1017-1025 (2022)
Only a few azoxy natural products have been identified despite their intriguing biological activities. Azodyrecins D–G, four new analogs of aliphatic azoxides, were identified from two Streptomyces species by a reactivity-based screening that targe
Externí odkaz:
https://doaj.org/article/0f15dddcffca4888840b6e1c49e31642
Autor:
Kei Kudo, Takehiro Nishimura, Ikuko Kozone, Junko Hashimoto, Noritaka Kagaya, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Engineering polyketide synthases is one of the most promising ways of producing a variety of polyketide derivatives. Exploring the undiscovered chemical space of this medicinally important class of middle molecular weight natural products wi
Externí odkaz:
https://doaj.org/article/b2430429dc1949ffa90e4ad9492f1d0d
Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy
Autor:
Soniya Bastola, Marat S. Pavlyukov, Daisuke Yamashita, Sadashib Ghosh, Heejin Cho, Noritaka Kagaya, Zhuo Zhang, Mutsuko Minata, Yeri Lee, Hirokazu Sadahiro, Shinobu Yamaguchi, Svetlana Komarova, Eddy Yang, James Markert, Louis B. Nabors, Krishna Bhat, James Lee, Qin Chen, David K. Crossman, Kazuo Shin-Ya, Do-Hyun Nam, Ichiro Nakano
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Intratumoural spatial heterogeneity is crucial to enhance therapeutic resistance in glioblastoma. Here, the authors show a paracrine signaling mechanism where glioblastoma-initiating cells located in the tumour edge elevate their malignancy by intera
Externí odkaz:
https://doaj.org/article/07b5f2bb5b4a4838a58f12fd8d7ba3c5
Autor:
Kei Kudo, Takuya Hashimoto, Junko Hashimoto, Ikuko Kozone, Noritaka Kagaya, Reiko Ueoka, Takehiro Nishimura, Mamoru Komatsu, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Several different genetic strategies have been reported for the modification of polyketide synthases but the highly repetitive modular structure makes this difficult. Here the authors report on an adapted Cas9 reaction and Gibson assembly to edit a t
Externí odkaz:
https://doaj.org/article/6d001e0fbfd74c5b9143e6e06438d202
Publikováno v:
The Journal of Antibiotics. 74:660-666
Recent progress in three-dimensional (3D) cell culture systems has attracted much attention in the fields of basic life science and drug development. Newly established methods include 3D co-culture, spheroid culture, and organoid culture; these metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7241099adb17623bed8bcdf038bb7a2e
https://doi.org/10.1038/s41429-021-00457-8
https://doi.org/10.1038/s41429-021-00457-8
Autor:
Tomohisa Kuzuyama, Hikaru Suenaga, Junko Hashimoto, Takuya Hashimoto, Noritaka Kagaya, Takehiro Nishimura, Kazuo Shin-ya, Makoto Nishiyama
Publikováno v:
The Journal of Antibiotics. 74:354-358
Using genome mining approach, we identified a novel biosynthetic gene cluster containing trans-AT type PKS genes from Streptomyces versipellis 4083-SVS6. A bacterial artificial chromosome (BAC) clone, pKU503JL68_PN1_P10-C12, accommodating the entire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf3a5fb4915c8be115addbdde229ed7
https://doi.org/10.1038/s41429-021-00410-9
https://doi.org/10.1038/s41429-021-00410-9
Autor:
Tomoya Yamaguchi, Ayumu Taguchi, Kazuo Shin-ya, Motoshi Suzuki, Takashi Takahashi, Lisa Kondo-Ida, Yukako Shimada, Behnoush Khaledian, Noritaka Kagaya, Taisuke Kajino
Publikováno v:
Cancer Science
We have previously identified receptor tyrosine kinase‐like orphan receptor 1 (ROR1) as a direct transcriptional target of TTF‐1/NKX2‐1, a lineage‐survival oncogene in lung adenocarcinoma. ROR1 sustains prosurvival signaling from multiple rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c0bebb7f8b2066c13b3f2d8bee9c1d
https://doi.org/10.1111/cas.14786
https://doi.org/10.1111/cas.14786
Autor:
Takuya Hashimoto, Haruo Ikeda, Noritaka Kagaya, Kei Kudo, Reiko Ueoka, Hikaru Suenaga, Kazuo Shin-ya, Ikuko Kozone, Junko Hashimoto
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:890-894
A novel methymycin analog, 12-ketomethymycin N-oxide, was produced by the heterologous expression of the pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900 together with 12-ketomethymycin, which was only isolated by the biotra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614f426d8f5d2c19bf6aaea4f0e37135
https://doi.org/10.1093/bbb/zbaa111
https://doi.org/10.1093/bbb/zbaa111
Autor:
Toshio Tsuchida, Kazuo Shin-ya, Noriaki Sakata, Masashi Itoh, Teppei Kawahara, Noritaka Kagaya, Miho Izumikawa
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 84:1570-1575
Chemical screening of culture medium from the soil fungus Stachybotrys sp. resulted in the isolation of the three new phenylspirodrimanes MBJ-0030 (1), MBJ-0031 (2) and MBJ-0032 (3). Their structures were determined by detailed analysis of spectrosco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e75a089587e817231927405288c41212
https://doi.org/10.1080/09168451.2020.1757402
https://doi.org/10.1080/09168451.2020.1757402
Autor:
Kazuo Shin-ya, Junko Hashimoto, Mamoru Komatsu, Takehiro Nishimura, Noritaka Kagaya, Ikuko Kozone, Haruo Ikeda, Hikaru Suenaga, Kei Kudo, Reiko Ueoka, Takuya Hashimoto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
One major bottleneck in natural product drug development is derivatization, which is pivotal for fine tuning lead compounds. A promising solution is modifying the biosynthetic machineries of middle molecules such as macrolides. Although intense studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78be128b5b7159b8fb2e6b3979f415fa
https://doaj.org/article/6d001e0fbfd74c5b9143e6e06438d202
https://doaj.org/article/6d001e0fbfd74c5b9143e6e06438d202