Výsledky vyhledávání - "Norita Sukri"

A comparative study of dynamic contrast-enhanced MRI parameters as biomarkers for anti-angiogenic drug therapy

Autor: Septian Hartono, Ai Bee Ong, Tong San Koh, Norita Sukri, Choon Hua Thng, Chuing Ing Wong, Rod A. Humerickhouse, Boon Cher Goh, Ross A. Soo, Helmut Rumpel, Bee Choo Tai, Albert S. C. Low

Publikováno v: NMR in Biomedicine. 24:1169-1180

The aim of the present study was to compare three tracer kinetics methods for the analysis of dynamic contrast-enhanced (DCE) MRI data, namely the generalized kinetics model, the distributed-parameter model and the initial area under the tumor tracer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f173e57a514370da654dbfe050c8435
https://doi.org/10.1002/nbm.1680

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Chemotherapy-induced tumor gene expression changes in human breast cancers

Autor: Norita Sukri, Xin Xu, Hui Ling Yap, Soo Chin Lee, Wee-Lee Yeo, Patrick Tan, Yi-Wan Lim, Boon Cher Goh, Philip Iau, Howard L. McLeod, Siew-Eng Lim, Sing-Huang Tan

Publikováno v: Pharmacogenetics and Genomics. 19:181-192

Studying chemotherapy-induced gene expression changes in vivo, which could provide insights into mechanisms of chemotherapy resistance.We analyzed and compared tumor gene expression changes of about 38 500 genes before and 3 weeks after doxorubicin o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00e48dc778d663155c735f3ac929f95
https://doi.org/10.1097/fpc.0b013e32831ebb5d

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A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers

Autor: Boon Cher Goh, How Sung Lee, Chiung-Ing Wong, Ross A. Soo, Norita Sukri, Lai-San Tham, Wei Peng Yong, Soo Chin Lee, Lingzhi Wang

Publikováno v: Cancer Chemotherapy and Pharmacology. 62:243-251

The aims were to determine the maximum tolerable dose (MTD) of docetaxel with CYP3A inhibition by ketoconazole, and to correlate the pharmacokinetics of docetaxel with midazolam phenotyping of CYP3A activity.Forty-one patients with refractory metasta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471690ebe44dd2574d5efecc587ad7be
https://doi.org/10.1007/s00280-007-0598-1

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Ketoconazole Renders Poor CYP3A Phenotype Status With Midazolam as Probe Drug

Autor: Ai-Bee Ong, Wei Peng Yong, How Sung Lee, Soo-Chin Lee, Boon Cher Goh, Norita Sukri, Ross A. Soo, Lai-San Tham, Lingzhi Wang, Lu Fan

Publikováno v: Therapeutic Drug Monitoring. 28:255-261

Drugs metabolized by cytochrome CYP3A isoenzymes have wide interindividual variability and normally distributed plasma clearance distributions. This makes precise dosing difficult to achieve clinically, which may compromise safe therapy. We hypothesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea13cb5b3b714cef34081baf1ca7c03a
https://doi.org/10.1097/01.ftd.0000194497.55269.d9

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Post-treatment tumor gene expression signatures are more predictive of treatment outcomes than baseline signatures in breast cancer

Autor: Howard L. McLeod, Mark F. Watson, Yi-Wan Lim, Benjamin Chuah, Philip Iau, Hui-Ling Yap, Wee Joo Chng, Siew-Eng Lim, Boon Cher Goh, Soo Chin Lee, Chiung-Ing Wong, Xin Xu, Norita Sukri, Shaik Ahmad Buhari, Jia-Yi Guo, Patrick Tan

Publikováno v: Pharmacogenetics and genomics. 19(11)

Objective Tumor gene expression signatures have been used to classify, prognosticate, and predict chemotherapy sensitivity in breast cancer, although almost all efforts have been focused on the unchallenged baseline tumor. Most cancer patients receiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb0615b7bb13c95d05d4b0c6e4f4760
https://pubmed.ncbi.nlm.nih.gov/19809382

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Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity

Autor: Chiung-Ing Wong, Norita Sukri, Hui-Ling Yap, Sing-Huang Tan, Lu Fan, Soo Chin Lee, Boon Cher Goh, Yok-Moi Khoo, How Sung Lee, Robert Lim, Jia-Yi Guo, Siew-Eng Lim, Philip Iau

Publikováno v: Pharmacogenetics and genomics. 18(7)

Objectives Doxorubicin is a cytotoxic drug with potential for severe myelosuppression that is highly variable and poorly predictable. Methods We correlated CBR1 and CBR3 genotypes with the pharmacokinetics and pharmacodynamics of doxorubicin in 101 S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177b151a28123b1df87acafd41eb63fc
https://pubmed.ncbi.nlm.nih.gov/18551042

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Use of peripheral blood genomic markers whose expression levels reflect that of breast tumor genomic markers to predict drug treatment and sensitivity

Autor: B. Goh, P. Iau, J. Lee, S. Lee, B. Chuah, Norita Sukri, X. Xu, P. Tan, S. Tan, S. Lim

Publikováno v: Journal of Clinical Oncology. 27:3588-3588

3588 Background: Tumor gene expression signatures have been used to predict drug response, and we have previously reported drug-induced signatures to be more informative than the untreated baseline signatures. However, repeated tumor sampling during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c66ab25032aa011830d5505c338774d6
https://doi.org/10.1200/jco.2009.27.15_suppl.3588

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Dynamic contrast enhanced MRI (DCE MRI) for Phase I anti-angiogenic trial: Comparison of the transfer constant (Ktrans) to blood flow and permeability derived by a distributed parameter model

Autor: Choon Hua Thng, Tong San Koh, Ai-Bee Ong, Rod A. Humerickhouse, H. Rumpel, Norita Sukri, Bee Choo Tai, Ross A. Soo, Boon Cher Goh, Septian Hartono

Publikováno v: Journal of Clinical Oncology. 26:3514-3514

3514 Background: The distributed parameter (DP) model is a DCE-MRI model that enables derivation of blood flow and capillary permeability-surface area product (PS). We aim to compare the DP model t...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::012b6a2638ec3970fcfd85e57d93b65c
https://doi.org/10.1200/jco.2008.26.15_suppl.3514

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Dynamic contrast enhanced MRI (DCE MRI) for assessment of effects of anti-angiogenic therapy: Comparison of the transfer constant (Ktrans) to blood flow and permeability derived by a distributed parameters model

Autor: Tong San Koh, Choon Hua Thng, Ai-Bee Ong, Boon Cher Goh, Rod A. Humerickhouse, Norita Sukri, James B. K. Khoo, Ross A. Soo, Bee Choo Tai, H. Rumpel

Publikováno v: Journal of Clinical Oncology. 25:14109-14109

14109 Background: Transfer constant (Ktrans) and IAUC60 normalized with arterial input function are commonly used dynamic contrast enhanced magnetic resonance imaging (DCE MRI) parameters. The distributed parameters model (DP) is a DCE MRI model that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::567f47f3bc795d5424b9baf1719f60ce
https://doi.org/10.1200/jco.2007.25.18_suppl.14109

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