Výsledky vyhledávání - "Norishige Sohtome"

Stereochemistry of NaBH4 Reduction of a 19-Carbonyl Group of 3-Deoxy Androgens. Synthesis of [19S-3H]- and [19R-3H]-Labeled Aromatase Inhibitors Having a 19-Hydroxy Group

Autor: Masao Nagaoka, Norishige Sohtome, Mitsuteru Numazawa

Publikováno v: Chemical and Pharmaceutical Bulletin. 52:722-726

To study the stereochemical aspects of the aromatase reaction of androst-4-en-17-one (1) and its 5-ene isomer 4, competitive inhibitors of aromatase, the [19S-(3)H]- and [19R-(3)H]-labeled 19-hydroxy derivatives 2 and 5, were synthesized through NaB(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda4423de4b2b8454b58237dca7ac2d4
https://doi.org/10.1248/cpb.52.722

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Aromatase reaction of 3-deoxyandrogens: steric mode of the C-19 oxygenation and cleavage of the C10-C19 bond by human placental aromatase

Autor: Masao Nagaoka, Mitsuteru Numazawa, Norishige Sohtome

Publikováno v: Biochemistry. 44(32)

Aromatase is a cytochrome P-450 enzyme complex that catalyzes the conversion of androst-4-ene-3,17-dione (AD) to estrone and formic acid through three sequential oxygenations of the 19-methyl group. To gain insight into the catalytic function of arom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5837910392d98371ec2ba5fb4ab17ef8
https://pubmed.ncbi.nlm.nih.gov/16086586

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