Zobrazeno 1 - 10
of 315
pro vyhledávání: '"Norio Taira"'
Publikováno v:
The Tohoku Journal of Experimental Medicine. 188:31-45
To elucidate the differences in mode and mechanism of action between YT-146, a highly selective adenosine A2 receptor agonist, and adenosine, we compared their effects on coronary circulation and myocardium and modifications of these effects by glibe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c43565374f08d64d2e0b599c0a74c1
https://doi.org/10.1620/tjem.188.31
https://doi.org/10.1620/tjem.188.31
Autor:
Norio Taira
Publikováno v:
Drugs. 66:1-3
Nifedipine was synthesized by Bayer Germany in 1966 and considered for clinical use as a coronary vasodilator in patients with angina pectoris. Japanese investigators played a great part in the pre-clinical and clinical development of nifedipine. Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea524d3dfe0b4c6dcda718feb736cbe9
https://doi.org/10.2165/00003495-200666991-00002
https://doi.org/10.2165/00003495-200666991-00002
Publikováno v:
Journal of Biological Chemistry. 272:19333-19338
The “ball and chain” model has been shown to be suitable for explaining the rapid inactivation of voltage-dependent K+ channels. For theDrosophila Shaker K+ channel (ShB), the first 20 residues of the amino terminus have been identified as the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e59db93934e86035198dd0014d7a0b
https://doi.org/10.1074/jbc.272.31.19333
https://doi.org/10.1074/jbc.272.31.19333
Publikováno v:
Journal of Molecular and Cellular Cardiology. 28:957-965
Recently, we have cloned a cDNA for a putative cardiac inward rectifier K+ channel (RBHIK1) from rabbit cardiac muscles. However, it's single channel characteristics have remained unknown. Therefore, we investigated the single channel characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0873ef7c6465877a10a7da610ba5be7f
https://doi.org/10.1006/jmcc.1996.0089
https://doi.org/10.1006/jmcc.1996.0089
Publikováno v:
Journal of Cardiovascular Pharmacology. 27:262-268
In isolated canine right ventricular muscles, we investigated the differences in antagonisms by beta-blockers against the positive inotropic effects (PIEs) of isoproterenol, a nonselective agonist, and T-0509, a beta1-selective agonist. The selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4bf343264966ac7e6e5d5f19fdd588e
https://doi.org/10.1097/00005344-199602000-00013
https://doi.org/10.1097/00005344-199602000-00013
Publikováno v:
British Journal of Pharmacology. 116:2062-2066
1. In the present study we estimated the KA value of endothelin-1 (ET-1) for ETA-receptors by a new method in which the level of expression of ETA-receptors in Xenopus oocytes was altered in a controlled way. 2. Kvl.2 (a delayed rectifier type K chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb6ecf29d4cdc850510405bfd213720
https://doi.org/10.1111/j.1476-5381.1995.tb16412.x
https://doi.org/10.1111/j.1476-5381.1995.tb16412.x
Publikováno v:
European Journal of Pharmacology. 281:151-159
We investigated the effects of the antiarrhythmic drugs, quinidine, disopyramide, flecainide, clofilium, verapamil, and the bradycardic drug, bertosamil, on the currents of the cloned K+ channels, KV1.2 (IK(V1.2)) and KV1.4 (IK(V1.4)), using the Xeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c163866adeaa128fd6c6922de5a1816a
https://doi.org/10.1016/0014-2999(95)00240-l
https://doi.org/10.1016/0014-2999(95)00240-l
Publikováno v:
British Journal of Pharmacology. 114:1289-1295
1. The mechanisms of action of semotiadil fumarate, a novel Ca2+ antagonist, were examined by measuring the cytosolic Ca2+ level ([Ca2+]i) and force of contraction in porcine coronary arteries, and by determining [3H]-pyrilamine binding to bovine cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd9efe6b6d5d62cfce0e9d8d6962283
https://doi.org/10.1111/j.1476-5381.1995.tb13345.x
https://doi.org/10.1111/j.1476-5381.1995.tb13345.x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1234:145-148
Recently, pIcln has been reported to be a regulator of a swelling-induced chloride conductance. We have cloned a cDNA RCL-H1 from rabbit heart, of which primary structure is highly homologous to that of pIcln. Outwardly rectifying currents were recor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4665b84420a4ae62d0b869c4d83cf0cd
https://doi.org/10.1016/0005-2736(95)00015-u
https://doi.org/10.1016/0005-2736(95)00015-u
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 268:451-454
To investigate mechanisms for the receptor-mediated inhibition of a rat cardiac K+ channel clone (KV1.2), we coexpressed KV1.2 with a subtype of endothelin receptors (ETA) in Xenopus oocytes. Effects of endothelin ETA receptor stimulation were mimick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16e9e45ce737ec9340334bcd49e0a2b
https://doi.org/10.1016/0922-4106(94)90073-6
https://doi.org/10.1016/0922-4106(94)90073-6