Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Norio Sasaoka"'
Autor:
Tomoko Hasegawa, Hanako O. Ikeda, Sachiko Iwai, Norio Sasaoka, Akira Kakizuka, Akitaka Tsujikawa
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients de
Externí odkaz:
https://doaj.org/article/8eeeba1c48204dceb4e036fedf10b1ea
Publikováno v:
iScience, Vol 10, Iss , Pp 211-221 (2018)
Summary: Milk sugar is composed of glucose and galactose. Galactose is less suitable as an energy source than glucose. Thus, it has been a puzzle as to why mammals utilize galactose as a major component of milk sugar. Here we show that in hypoglycemi
Externí odkaz:
https://doaj.org/article/f94fe8c6f4b54a1aac75f3620f9d9d8f
Autor:
Yumi Konagaya, Kenta Terai, Yusuke Hirao, Kanako Takakura, Masamichi Imajo, Yuji Kamioka, Norio Sasaoka, Akira Kakizuka, Kenta Sumiyama, Tomoichiro Asano, Michiyuki Matsuda
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2628-2638 (2017)
AMP-activated protein kinase (AMPK), a master regulator of cellular metabolism, is a potential target for type 2 diabetes. Although extensive in vitro studies have revealed the complex regulation of AMPK, much remains unknown about the regulation in
Externí odkaz:
https://doaj.org/article/e147a42141a0412a92ebec97a2e748cf
Autor:
Masaki Nakano, Hiromi Imamura, Norio Sasaoka, Masamichi Yamamoto, Norihito Uemura, Toshiyuki Shudo, Tomohiro Fuchigami, Ryosuke Takahashi, Akira Kakizuka
Publikováno v:
EBioMedicine, Vol 22, Iss C, Pp 225-241 (2017)
Parkinson's disease is assumed to be caused by mitochondrial dysfunction in the affected dopaminergic neurons in the brain. We have recently created small chemicals, KUSs (Kyoto University Substances), which can reduce cellular ATP consumption. By co
Externí odkaz:
https://doaj.org/article/2f72dec8367049909169db5baa4c869b
Autor:
Norio Sasaoka, Megumi Sakamoto, Shoko Kanemori, Michiru Kan, Chihiro Tsukano, Yoshiji Takemoto, Akira Kakizuka
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87185 (2014)
Coincident with the expanding population of aged people, the incidence of Alzheimer disease (AD) is rapidly increasing in most advanced countries. At present, no effective prophylactics are available. Among several pathological mechanisms proposed fo
Externí odkaz:
https://doaj.org/article/bd5f5cea50344da8a134097727b425fe
Autor:
Katsuhiro Murakami, Yuzuru Ichinohe, Masaaki Koike, Norio Sasaoka, Shun-ichiro Iemura, Tohru Natsume, Akira Kakizuka
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56012 (2013)
Catalase is a key antioxidant enzyme that catalyzes the decomposition of hydrogen peroxide (H2O2) to water and oxygen, and it appears to shuttle between the cytoplasm and peroxisome via unknown mechanisms. Valosin-containing protein (VCP) belongs to
Externí odkaz:
https://doaj.org/article/64d9a17874564dbcbd0672700be7fd68
Autor:
Sachiko Iwai, Akitaka Tsujikawa, Tomoko Hasegawa, Hanako Ohashi Ikeda, Akira Kakizuka, Norio Sasaoka
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients develop pro
Autor:
Benoit Viollet, Norio Sasaoka, Elizabeth M. Kwong, Kristiina Vuori, Robert C. Liddington, Ming Zhao, Darren Finlay
Publikováno v:
Cell Signal
Autophagy is a multi-step process regulated in part by AMP-activated protein kinase (AMPK). Phosphorylation of threonine 172 on the AMPK α-subunit enhances AMPK kinase activity, resulting in activation of downstream signaling. Integrin-mediated cell
Publikováno v:
iScience, Vol 10, Iss, Pp 211-221 (2018)
iScience
iScience
Summary Milk sugar is composed of glucose and galactose. Galactose is less suitable as an energy source than glucose. Thus, it has been a puzzle as to why mammals utilize galactose as a major component of milk sugar. Here we show that in hypoglycemic
Autor:
Hanako Ohashi Ikeda1,2, Norio Sasaoka2, Masaaki Koike2, Noriko Nakano1, Yuki Muraoka1, Yoshinobu Toda3, Tomohiro Fuchigami4, Toshiyuki Shudo1,2,4, Ayana Iwata2, Seiji Hori2, Nagahisa Yoshimura1, Akira Kakizuka2 kakizuka@lif.kyoto-u.ac.jp
Publikováno v:
Scientific Reports. 8/8/2014, p1-9. 9p.