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Akademický článek

Protocol to image and analyze the morphology of mouse peripheral nerves using transmission electron microscopy

Autor: Hiromi Nakai-Shimoda, Tatsuhito Himeno, Mikio Motegi, Norio Ozeki, Rieko Inoue, Tomohide Hayami, Emiri Miura-Yura, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Masaki Kondo, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya

Publikováno v: STAR Protocols, Vol 3, Iss 3, Pp 101591- (2022)

Summary: Morphological analysis of peripheral nerves in mouse models can be used to characterize the pathophysiology of peripheral nerve disease, but obtaining high-quality electron micrographs can be challenging. Here, we present a protocol to obtai

Externí odkaz: https://doaj.org/article/67480149bc814bc88447853f6a51127f

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Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice

Publikováno v: Biochemical and Biophysical Research Communications. 532:47-53

Although diabetic polyneuropathy (DPN) is the commonest diabetic complication, its pathology remains to be clarified. As previous papers have suggested the neuroprotective effects of glucagon-like peptide-1 in DPN, the current study investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b2ba5fceb816bdbf39f99a82b3c75f
https://doi.org/10.1016/j.bbrc.2020.08.007

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Investigation of the ototoxicity of gadoteridol (ProHance) and gadodiamide (Omniscan) in mice

Autor: Hiroshi Nonoyama, Tohru Tanigawa, Hirokazu Tanaka, Kenta Murotani, Nobuyuki Katahira, Rei Shibata, Keiji Takemura, Norio Ozeki, Yuichiro Horibe, Hiromi Ueda

Publikováno v: Acta oto-laryngologica. 136(11)

In the mouse, when a tympanic perforation is present, gadoteridol does not seem to cause ototoxicity. Gadodiamide may cause mild ototoxicity other than toxicity to the outer hair cells of the cochlea.Endolymphatic hydrops have been visualized through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9884b060db1898ce20f2fd7af8efadd
https://pubmed.ncbi.nlm.nih.gov/27315460

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Membranous Nephropathy and Pulmonary Alveolar Proteinosis

Autor: Norio Ozeki, Hirokazu Imai, Kazuhiro Nishikawa, Naoto Miura, Wataru Kitagawa, Yukari Kashima, Seiko Matsui, Harutaka Yamada

Publikováno v: Internal Medicine. 46:1441-1446

A 47-year-old woman with a severe cough and high-grade fever demonstrated proteinuria of 3.2 g/day. Chest radiograph and CT scan revealed scattered small nodules and ground-glass opacities with interlobular septal thickening in both lungs. The serum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acd7c29c7459cdd20100f33a2106f91
https://doi.org/10.2169/internalmedicine.46.0129

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Apoptosis Induced by Culturing MH134 Cells in the Presence of Porcine Skin Gelatin In Vitro

Autor: Takashi Kojima, Norio Ozeki, Yukio Yoshida, Hiroshi Nagata, Nobuhiro Ito, Toshiaki Nonami

Publikováno v: Cancer Biotherapy and Radiopharmaceuticals. 17:379-384

Porcine skin (PS) gelatin showed antitumor effect in vitro on MH134 murine hepatoma cells. We analyzed the effect of PS gelatin on MH134 cells compared to the effect of Bovine bone (BB) gelatin, 5-Fluorouracil (5-FU) and 7-ethyl-10-hydroxycamptotheci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdb7617e93cabc576afb5af7e4948b3
https://doi.org/10.1089/108497802760363178

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Ultrastructural identification of light microscopic giant mitochondria in alcoholic liver disease

Autor: Masahiro Suzuki, Norio Ozeki, Kazuhito Shimizu, Takao Inagaki, Susumu Kobayashi, Kato Katsuhisa, Yoshitaka Fukuzawa, Katsumi Kato

Publikováno v: Hepatology (Baltimore, Md.). 15(1)

Ultrastructural identification of light microscopic giant mitochondria was performed on the same specimens for light and electron microscopic observations. The liver tissue specimens were fixed in OsO4, embedded in epoxy resin, cut 4 μm thick and st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359a981548f1a660e5698c4dd58ec6cb
https://pubmed.ncbi.nlm.nih.gov/1727798

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