Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Norio Motohashi"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Human urine-derived cells (UDCs) are primary cultured cells originating from the upper urinary tract and are known to be multipotent. We previously developed MYOD1-transduced UDCs (MYOD1-UDCs) as a model recapitulating the pathogenesis of Du
Externí odkaz:
https://doaj.org/article/e26f4968a67247378f28053aacbd5fe8
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-13 (2023)
Abstract Skeletal muscle comprises different muscle fibers, including slow- and fast-type muscles, and satellite cells (SCs), which exist in individual muscle fibers and possess different myogenic properties. Previously, we reported that myoblasts (M
Externí odkaz:
https://doaj.org/article/24d6a85f204e401197ba4d7fd6519afd
Autor:
Takami Ishizuka, Hirofumi Komaki, Yasuko Asahina, Harumasa Nakamura, Norio Motohashi, Eri Takeshita, Yuko Shimizu‐Motohashi, Akihiko Ishiyama, Chihiro Yonee, Shinsuke Maruyama, Eisuke Hida, Yoshitsugu Aoki
Publikováno v:
Neuropsychopharmacology Reports, Vol 43, Iss 2, Pp 277-286 (2023)
Abstract Aim The purpose of this study is to evaluate the safety and pharmacokinetics of the novel morpholino oligomer NS‐089/NCNP‐02 which can induce exon 44 skipping, in patients with DMD. Additionally, we aimed to identify markers predictive o
Externí odkaz:
https://doaj.org/article/ee15b39e2405482aa4a970d87a49bf53
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Approval of therapeutic RNA molecules, including RNA vaccines, has paved the way for next-generation treatment strategies for various diseases. Oligonucleotide-based therapeutics hold particular promise for treating incurable muscular dystrophies, in
Externí odkaz:
https://doaj.org/article/a0505c4e0d714db3bda8fe19aa24e693
Autor:
William J. Valentine, Sherif A. Mostafa, Suzumi M. Tokuoka, Fumie Hamano, Natsuko F. Inagaki, Joel Z. Nordin, Norio Motohashi, Yoshihiro Kita, Yoshitsugu Aoki, Takao Shimizu, Hideo Shindou
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
In Duchenne muscular dystrophy (DMD), lack of dystrophin increases the permeability of myofiber plasma membranes to ions and larger macromolecules, disrupting calcium signaling and leading to progressive muscle wasting. Although the biological origin
Externí odkaz:
https://doaj.org/article/dffd91e077b74473be10610053a34c06
Publikováno v:
Journal of Physical Fitness and Sports Medicine, Vol 4, Iss 5, Pp 347-350 (2015)
Epidemiological findings suggest that the pathogenesis and mortality rates of many age-related diseases are associated with sarcopenia, a condition defined as age-associated muscle weakening and atrophy. Skeletal muscle plays important roles beyond b
Externí odkaz:
https://doaj.org/article/ec652c635af840948424d815d17c3553
Publikováno v:
Cells, Vol 8, Iss 9, p 1066 (2019)
Muscular dystrophies (MDs) are a group of heterogeneous genetic disorders caused by mutations in the genes encoding the structural components of myofibres. The current state-of-the-art treatment is oligonucleotide-based gene therapy that restores dis
Externí odkaz:
https://doaj.org/article/b82ca30ec60445dbb6f700255e234d05
Publikováno v:
Journal of Physical Fitness and Sports Medicine, Vol 1, Iss 1, Pp 151-154 (2012)
Skeletal muscle is the most abundant tissue in the mammalian body and is composed of multinucleated fibers that contract to generate force and movement. In addition, skeletal muscle has the ability to regenerate following severe damage by exercise, t
Externí odkaz:
https://doaj.org/article/3694fbf5e0004d78babce2ceb244d0d5
Autor:
Ken Shirato, Jun Tanihata, Norio Motohashi, Kaoru Tachiyashiki, Akio Tomoda, Kazuhiko Imaizumi
Publikováno v:
Journal of Pharmacological Sciences, Vol 104, Iss 2, Pp 146-152 (2007)
Clenbuterol [CLE: 4-amino-α(t-butyl-amino)methyl-3,5-dichlorobenzyl alcohol] is well known as a potent β2-adrenergic agonist and non-steroidal anabolic drug, and thus it is generally used for sports doping and asthma therapy. Although the functions
Externí odkaz:
https://doaj.org/article/95c44caf20454ff5a771d2e6e3fc1b68
Publikováno v:
Stem Cells International, Vol 2015 (2015)
Externí odkaz:
https://doaj.org/article/885b0d836625467a89035bfed1564679