Výsledky vyhledávání - "Norio Karibe"

Synthesis of 14C-labelled (S)-(+)-2-[4-(p-fluorobenzoyl)-1-piperidyl]-1-naphthylethanol hydrochloride

Autor: R. M. Rosser, Norio Karibe, Hachiro Sugimoto, Masataka Ueda

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 28:823-830

14C-labelled (S)-(+)-2-[4-(p-fluorobenzoyl)-1-piperidyl]-1-naphthylethanol hydrochloride (5), an anti-ischemic drug, was synthesized for studying the pharmacokinetic profiles of the compound in four steps using 2-[carbonyl-14C]acetonaphthone (1) as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6374e7186111a150b2602e2b164fbb65
https://doi.org/10.1002/jlcr.2580280712

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Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives

Autor: Atsushi Sasaki, Youichi Iimura, Kunizo Higurashi, Yutaka Tsuchiya, Hiroyuki Sugumi, Y Kawakami, Norio Karibe, T Nakamura, Hachiro Sugimoto, Shin Araki

Publikováno v: Journal of Medicinal Chemistry. 33:1880-1887

A series of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives was synthesized and evaluated for anti-acetylcholinesterase (anti-AChE) activity. Substituting the benzamide with a bulky moiety in the para position led to a substantial increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056c79d7fe20f9525541ab376e8c2c07
https://doi.org/10.1021/jm00169a008

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Synthesis ofα-Tocopherol: Scandium(III) Trifluoromethanesulfonate as an Efficient Catalyst in the Reaction of Hydroquinone with Allylic Alcohol

Autor: Kazushi Hayashi, Hisashi Yamamoto, Makoto Matsui, Norio Karibe

Publikováno v: Bulletin of the Chemical Society of Japan. 68:3569-3571

Scandium(III) trifluoromethanesulfonate was found to be an efficient catalyst as a Lewis acid for the condensation reaction of trimethylhydroquinone with isophytol to afford α-tocopherol. The condensation reaction proceeded smoothly using only a 0.0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dafd3755848b2c6ea1f2a3b4a7432a05
https://doi.org/10.1246/bcsj.68.3569

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Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives

Autor: Kiyomi Yamatsu, Hiroyuki Sugumi, Yoshiharu Yamanishi, Norio Karibe, Atsushi Sasaki, Yutaka Tsuchiya, Kunizo Higurashi, Yoichi Iimura, Hachiro Sugimoto, Shin Araki

Publikováno v: Journal of medicinal chemistry. 35(24)

Following the discovery of a new series of 1-benzyl-4-[2-(N-benzoyl-N-methylamino)ethyl]piperidine (2) derivatives with a potent anti-acetylcholinesterase (anti-AChE) activity, we extended the structure-activity relationships (SAR) to rigid analogues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcce7a8da170e6dc508a19aad5bd14e9
https://pubmed.ncbi.nlm.nih.gov/1469686

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Chemistry of 2-methoxy-2,5-cyclohexadienones. I. Photochemistry of 2-methoxy-4,4-dimethyl-2,5-cyclohexadienone

Autor: Takao Yamazaki, Katsuhide Matoba, Norio Karibe

Publikováno v: Chemical and Pharmaceutical Bulletin. 30:3906-3911

The title compound, 2-methoxy-4, 4-dimethyl-2, 5-cyclohexadienone (V), was prepared from 2-methoxy-4, 4-dimethyl-2-cyclohexenone (VIa). A methanolic solution of V was irradiated with a 200 W mercury lamp at -3°C to give 2, 2-dimethoxy-6, 6-dimethylb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::020534a84001e35fd4a48eef476fb382
https://doi.org/10.1248/cpb.30.3906

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Synthesis of 14C-labelled 2-[4-(p-fluorobenzoyl)piperidin-1-yl]-2′-acetonaphthone hydrochloride (E-2001-14C)

Autor: Mannen Mishima, Hachiro Sugimoto, Norio Karibe, Takaharu Nakamura

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 27:417-421

14C-labelled 2-[4-(p-fluorobenzoyl)piperidin-1-yl]-2′-acetonaphthone hydrochloride (4), a glutamate release inhibitor for studying the pharmacokinetic profiles of E-2001, was synthesized in two steps using 2-bromo-2′-[carbonyl-14C]-acetonaphthone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b072574b80da8f06167bc6d732bcb8f9
https://doi.org/10.1002/jlcr.2580270408

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Chemistry of 2-methoxy-2,5-cyclohexadienones. II. Oxidation of 2-methoxy-4,4-dimethyl-2,5-cyclohexadienone

Autor: Katsuhide Matoba, Norio Karibe, Takao Yamazaki

Publikováno v: Chemical and Pharmaceutical Bulletin. 32:2639-2645

2-Methoxy-4, 4-dimethyl-2-cyclohexenone (II) afforded 5, 6-epoxy-6-methoxy-4, 4-dimethyl-6-hexanolide (III) upon reaction with m-chloroperbenzoic acid in 1, 1, 1-trichloroethane. On the other hand, the treatment of II with the same reagent in an aque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1af6744f90c67782721705d64b165121
https://doi.org/10.1248/cpb.32.2639

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SIGNIFICANCE OF GASTRIC MUCO-SUBSTANCE RELATED TO THE PATHOGENESIS AND TREATMENT OF GASTRIC ULCER

Autor: Yoshiyuki Hatayama, Hideyuki Ichikawa, Shiro Hayashi, Norio Karibe, Tadashi Mizuno, Hideo Koike

Publikováno v: The Japanese Journal of Gastroenterological Surgery. 12:387-392

十二指腸潰瘍の成因として, 酸分泌亢進が第一にあげられるのに対して, 胃潰瘍の場合にはこの酸分泌の亢進が顕著でなく, 低酸, 無酸状態下でも発生しているために, いろいろな発生要因

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a86fffbac6f49e5ba729d637d1c374c
https://doi.org/10.5833/jjgs.12.387

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