Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Norio Goto"'
Autor:
Masanari Kuwahara, Yukio Akasaki, Norio Goto, Ichiro Kurakazu, Takuya Sueishi, Masakazu Toya, Taisuke Uchida, Tomoaki Tsutsui, Ryota Hirose, Hidetoshi Tsushima, Yasuharu Nakashima
Publikováno v:
BMC Pharmacology and Toxicology, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background Adipose-derived mesenchymal stem cells (ADMSCs) are a promising source of material source for medical regeneration of cartilage. Growth factors, including transforming growth factor-β (TGFβ) subfamily members and bone morphogene
Externí odkaz:
https://doaj.org/article/ab8b470fa11744a1b0cad6068018558b
Autor:
Shunsuke Nakamura, Hideki Mizu-uchi, Yukio Akasaki, Takenori Akiyama, Norio Goto, Ken Okazaki, Satoshi Hamai, Yasuharu Nakashima
Publikováno v:
Knee Surgery, Sports Traumatology, Arthroscopy. 27:2617-2623
Varus alignment is known as one of the major causes of medial compartment osteoarthritis (OA). Medial meniscus extrusion also plays a critical role in the in the development of OA. However, studies on the exact relationship between alignment paramete
Autor:
Norio Goto, Ken Okazaki, Yasuharu Nakashima, Takuya Sueishi, Yukio Akasaki, Tomás Duffy, Mitsumasa Hayashida, Ichiro Kurakazu, Martin Lotz, Hidetoshi Tsushima, Masakazu Toya, Masanari Kuwahara
Publikováno v:
J Biol Chem
The forkhead box O (FOXO) proteins are transcription factors involved in the differentiation of many cell types. Type II collagen (Col2) Cre-Foxo1-knockout and Col2-Cre-Foxo1,3,4 triple-knockout mice exhibit growth plate malformation. Moreover, recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c389dc73af8fdcc5eb8daecd921adc
http://hdl.handle.net/2324/4060050
http://hdl.handle.net/2324/4060050
Autor:
Yukio Akasaki, Umito Kuwashima, Shinya Kawahara, Hidetoshi Tsushima, Norio Goto, Satoshi Hamai, Yasuharu Nakashima, Hideya Kawamura, Ken Okazaki, Hideki Mizu-uchi, Kenyu Iwasaki
Publikováno v:
J Orthop
Background Both intra-articular and extra-articular knee alignment pathologies can affect clinical outcomes after high tibial osteotomy. The purpose of this study was to investigate post-operative knee coronal alignment parameters that affect long-te
Autor:
Yasuharu Nakashima, Tomohiro Masuzaki, Kohei Ishihara, Noriyuki Yasunami, Yukio Akasaki, Koji Murakami, Norio Goto, Ken Okazaki, Kiyoshi Koyano, Yasunori Ayukawa
Publikováno v:
Journal of Orthopaedic Research. 35:2465-2475
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme of the mevalonate pathway. The anti-inflammatory effect of statins has been reported in recent years. The present st
Autor:
Ichiro Kurakazu, Hidetoshi Tsushima, Mitsumasa Hayashida, Takuya Sueishi, Taisuke Uchida, Norio Goto, Hirofumi Bekki, Masakazu Toya, Martin Lotz, Masanari Kuwahara, Yukio Akasaki, Yasuharu Nakashima
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)References. 72(4)
OBJECTIVE NF-κB-dependent signaling is an important modulator in osteoarthritis (OA), and G protein-coupled receptor kinase 5 (GRK5) regulates the NF-κB pathway. This study was undertaken to investigate the functional involvement of GRK5 in OA path
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1084-1091
Two creams containing 20% (w/w) urea and various emulsifiers, a nonionic surfactant (NS) and lecithin (LEC), were prepared, and the rate of crystallization following application of the cream and differences in the properties of the deposits were inve
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1092-1098
The transfer of urea from a urea formulation to the stratum corneum varies with the formulation base and form, and impacts the formulation's therapeutic effect. Consequently, determining the amount of urea transferred is essential for developing effi
Autor:
Norio, Goto, Ken, Okazaki, Yukio, Akasaki, Kohei, Ishihara, Koji, Murakami, Kiyoshi, Koyano, Yasunori, Ayukawa, Noriyuki, Yasunami, Tomohiro, Masuzaki, Yasuharu, Nakashima
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 35(11)
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme of the mevalonate pathway. The anti-inflammatory effect of statins has been reported in recent years. The present st
Publikováno v:
Chemicalpharmaceutical bulletin. 64(8)
In drug formulations for external application, variations in the state of pharmaceutical agents within the base formulation may affect the transfer of agents to the skin. Here, we use Raman spectroscopic methods to acquire more detailed information o