Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Norio Awata"'
1
Simple high-performance liquid chromatography determination of ampicillin in human serum using solid-phase extraction disk cartridges
Autor: Fumio Sakamoto, Kayoko Kobayashi, Norio Awata, Mitsuhiro Ishida
Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 727:245-248
A simple and reproducible method for the analysis of ampicillin in human serum was developed. Serum samples were extracted using solid-phase extraction disk cartridges containing a sorbent of styrene divinyl/benzene. Extracts were separated by revers
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec94472e15623ffa56d17f22e3e461b
https://doi.org/10.1016/s0378-4347(98)00588-x
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2
Novel immunoaffinity extraction for liquid chromatographic determination of major metabolites of 4-acetoxy-2-(4-methylphenyl)benzothiazole in plasma
Autor: Junichi Goto, Shinichi Miyairi, Norio Awata, Toshio Nambara, Hitoshi Shimada
Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 12:389-395
Group extraction of the metabolites of 4-acetoxy-2-(4-methylphenyl)benzothiazole has been achieved through the use of an immunoaffinity adsorbent. The antisera elicited from an immunogen, 4-hydroxy-2-(4-formylphenyl)benzothiazole O-carboxymethyloxime
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2169203be0f25f1318a0fc6ed622a9
https://doi.org/10.1016/0731-7085(94)90016-7
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3
Placental Transfer and Mammary Excretion of 1-(Bis(4-fluorophenyl)-methyl)-4-(2,3,4-trimethoxybenzyl)piperazine Dihydrochloride(KB-2796) in Rats
Autor: Yoshiharu Katami, Kazumi Ichige, Takanori Sakai, Tsuneo Kawashima, Norio Awata, Osamu Satomi, Masao Ishizaki, Yoshio Esumi, Hiromi Hirano
Publikováno v: Drug Metabolism and Pharmacokinetics. 9:536-546
The placental transfer and mammary excretion of 1-[bis(4-fluorophenyl)-methyl]-4-(2, 3, 4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796) were studied in rats after oral administration of 14C-labeled KB-2796. 1. The whole-body autoradiograms af
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f690a4f7c48e50a2abfd5bb5c9709ba
https://doi.org/10.2133/dmpk.9.536
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4
Absorption, Distribution and Excretion of a New Antiplatelet Drug, Ethyl 2-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)pyrrol-1-ylacetate, (KBT-3022), after Single Oral Asministration in Mice
Autor: Masayuki Kurotori, Miho Miyake, Norio Awata, Yuichiro Nakada, Hitoshi Shimada, Katsuyuki Hori, Masaaki Fujikawa, Katsumasa Arakawa, Kazumi Ichige
Publikováno v: Drug Metabolism and Pharmacokinetics. 9:265-277
The absorption, distribution and excretion of ethyl 2-[4, 5-bis (4-methoxyphenyl) thiazol-2-yl]pyrrol-1-ylacetate (KBT-3022) were studied after administration of 14C-KBT-3022 to mice. Maximum plasma levels (Cax) appeared at 0.5 hr after oral administ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92df3712a55ca8493b0c0b999aa10b0b
https://doi.org/10.2133/dmpk.9.265
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5
Transfer a New Antiplatelet Drug, Ethyl 2-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)pyrrol-1-ylacetate(KBT-3022), to Fetus in Mice and Milk in Rats
Autor: Yuichiro Nakada, Masayuki Kurotori, Kazumi Ichige, Katsumasa Arakawa, Katsuyuki Hori, Norio Awata
Publikováno v: Drug Metabolism and Pharmacokinetics. 9:296-307
Transfer to fetus in mice and milk in rats were investigated after oral administration of an antiplatelet drug, 14C-KBT-3022 at a dose of 2 mg/kg. 1. The level of radioactivity in the fetus as revealed by whole body autoradiography, was lower than in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54391e60be96b7cc97c0ce7afce5ec74
https://doi.org/10.2133/dmpk.9.296
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7
Absorption, Distribution, Metabolism, Excretion and Effects on the Hepatic Drug Metabolizing Enzymes of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride(KB-2796) after Multiple Oral Administration in Rats
Autor: Yoshiharu Katami, Takanori Sakai, Yoshio Esumi, Tsuneo Kawashima, Norio Awata, Kazumi Ichige, Masao Ishizaki, Osamu Satomi, Hiromi Hirano
Publikováno v: Drug Metabolism and Pharmacokinetics. 9:522-535
The absorption, distribution, metabolism, excretion and the effect on the drug-metabolizing enzyme activities of 1-[bis (4-fluorophenyl) methyl]-4 (2, 3, 4-trimethoxybenzyl) piperazine dihydrochloride (KB-2796) were studied in male rats during and af
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::508100ee35c93784124455559f513d7f
https://doi.org/10.2133/dmpk.9.522
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8
Absorption, Distribution, Excretion and Effects on Drug Metabolizing Enzyme Activities of a New Antiplatelet Drug, Ethyl 2-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)pyrrol-1-ylacetate(KBT-3022), after Multiple Oral Administration in Mice
Autor: Kazumi Ichige, Katsumasa Arakawa, Yuichiro Nakada, Masayuki Kurotori, Norio Awata, Katsuyuki Hori, Masaaki Fujikawa
Publikováno v: Drug Metabolism and Pharmacokinetics. 9:278-295
Absorption, distribution, excretion, enzyme induction and effect to platelet were investigated in male mice after oral administration of an antiplatelet drug, KBT-3022. 1. Radioactivity levels in the plasma 24 hr after daily oral administration of 14
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::644661c0c7b43a6eebc1a5bfc89629d4
https://doi.org/10.2133/dmpk.9.278
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9
Metabolic Fate of Anti-Ulcer Agent 4-Methoxyphenyl-4-(3,4,5-trimethoxybenzyl)-1-piperazineacetate monofumarate monohydrate (KB-5492) (I): Absorption, Distribution and Excretion after Single Administration in Rats
Autor: Masato Horiuchi, Takanori Sakai, Yoshiko Adachi, Norio Awata
Publikováno v: Drug Metabolism and Pharmacokinetics. 9:97-109
The absorption, distribution and excretion of 4-methoxyphenyl 4-(3, 4, 5-trimethoxybenzyl)-1-piperzineacetate monofumarate monohydrate (KB-5492) were studied in rats after a single oral administration of 14C-KB-5492. The plasma radioactivity reached
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db3584bd13b7b8e9893f38028d27cf21
https://doi.org/10.2133/dmpk.9.97
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10
Some factors affecting the vaginal absorption of human calcitonin in rats
Autor: Yuichiro Nakada, Miho Miyake, Norio Awata
Publikováno v: International Journal of Pharmaceutics. 89:169-175
We studied the absorption of human calcitonin (HCT) from rat vaginal mucosa. The absorption of HCT was affected by pH, but scarcely by the osmotic pressure of the HCT solution. The pharmacological availability of HCT after vaginal administration with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81d38d986bb3d4efe25e31f715d429bb
https://doi.org/10.1016/0378-5173(93)90240-g
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