Zobrazeno 1 - 10
of 314
pro vyhledávání: '"Norio, Ogawa"'
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106362 (2014)
L-DOPA is therapeutically efficacious in patients with Parkinson's disease (PD), although dopamine (DA) neurons are severely degenerated. Since cortical astrocytes express neutral amino acid transporter (LAT) and DA transporter (DAT), the uptake and
Externí odkaz:
https://doaj.org/article/d3d1a899d08d4c9a853ca5954dbae6ca
Autor:
Masato Asanuma, Ikuko Miyazaki, Francisco J Diaz-Corrales, Youichirou Higashi, Masayoshi Namba, Norio Ogawa
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65983 (2013)
Tyrosinase, which catalyzes both the hydroxylation of tyrosine and consequent oxidation of L-DOPA to form melanin in melanocytes, is also expressed in the brain, and oxidizes L-DOPA and dopamine. Replacement of dopamine synthesis by tyrosinase was re
Externí odkaz:
https://doaj.org/article/e067c4fbfe49493fa397a86a860ed6a9
Autor:
Masato Asanuma, Norio Ogawa, Ken ichi Tanaka, Hiroaki Kaji, Kaori Miyatake, Hiroya Ogo, Erika Tokudome, Kanako Sonoda
Publikováno v:
Neurological Research. 34:619-622
We have searched for low-molecular-weight compounds as potent new non-immunosuppressive immunophilin ligands (NI-IPLs) that are stronger than existent NI-IPLs such as GPI1046 and/or V10367 from the perspective of neuroprotective efficacy. We selected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06815d41f668ceb362116d0ecf6f8b6a
https://doi.org/10.1179/1743132812y.0000000001
https://doi.org/10.1179/1743132812y.0000000001
Autor:
Ko Miyoshi, Masato Asanuma, Nobutaka Hattori, Norio Ogawa, Francisco J. Diaz-Corrales, Ikuko Miyazaki
Publikováno v:
Neurotoxicity Research. 14:295-305
Aggregation of proteins in the centrosome is implicated in the pathophysiology of Parkinson's disease. However, the relevance of the centrosome in neurodegeneration is still obscure. Centrosome duplication is initiated by the cyclin E/cyclin-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6824718e294c7124544cb9041b62ff07
https://doi.org/10.1007/bf03033854
https://doi.org/10.1007/bf03033854
Specific induction of PAG608 in cranial and spinal motor neurons of L-DOPA-treated parkinsonian rats
Autor:
Ikuko Miyazaki, Youichirou Higashi, Norio Ogawa, Francisco J. Diaz-Corrales, Masako Shimizu, Maria J. Eslava-Alva, Masato Asanuma
Publikováno v:
Neuroscience Research. 60:355-363
We identified p53-activated gene 608 (PAG608) as a specifically induced gene in striatal tissue of L-DOPA (100mg/kg)-injected hemi-parkinsonian rats using differential display assay. In the present study, we further examined morphological distributio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4bca0da225604d717ed702220acdbc
https://doi.org/10.1016/j.neures.2007.12.006
https://doi.org/10.1016/j.neures.2007.12.006
Autor:
Masato Asanuma, Ko Miyoshi, Miho Murata, Francisco J. Diaz-Corrales, Norio Ogawa, Ikuko Miyazaki
Publikováno v:
Neuroscience Research. 60:106-113
The neurotoxicity of dopamine (DA) quinones as dopaminergic neuron-specific oxidative stress is considered to play a role in the pathogenesis and/or progression of Parkinson's disease (PD), since DA quinones conjugate with several key PD pathogenic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c61b74b4edf3ee26234c8d90191456
https://doi.org/10.1016/j.neures.2007.10.002
https://doi.org/10.1016/j.neures.2007.10.002
Publikováno v:
Okayama Igakkai Zasshi (Journal of Okayama Medical Association). 119:235-239
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94924e6f3f1e9221a0c9ea4441fde61f
https://doi.org/10.4044/joma.119.235
https://doi.org/10.4044/joma.119.235
Publikováno v:
Neuroscience Letters. 410:85-89
To clarify the possible role of in the in vivo toxic effects of 6-hydroxydopamine (6-OHDA), especially caspase activations, we examined its effects on striatal lipid peroxidation (LPO) and caspase activations in 6-OHDA-lesioned mice. Both dopamine (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8953f1b534f6c26239ab3d2a44ab4025
https://doi.org/10.1016/j.neulet.2006.08.021
https://doi.org/10.1016/j.neulet.2006.08.021
Autor:
Osamu, Fujita, Masato, Asanuma, Teruhiko, Yokoyama, Ikuko, Miyazaki, Norio, Ogawa, Hiromi, Kumon
Publikováno v:
Acta Medica Okayama. 60(6):299-309
We examined the involvement of the signal transducer and activator of transcription 3 (STAT3) in bladder outlet obstruction (BOO)-induced bladder smooth muscle hypertrophy using a rat in vivo and in vitro study. BOO induced increases in bladder weigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::44ce43e12c2d71276614363247d1d5cc
https://ousar.lib.okayama-u.ac.jp/30724
https://ousar.lib.okayama-u.ac.jp/30724
Publikováno v:
Psychiatry and Clinical Neurosciences. 60:S18-S26
Recently, the formation of inclusion bodies in several neurodegenerative diseases, including Parkinson's disease, has been associated with the aggregation of unfolded proteins recruited in the centrosome. We have reported previously that rotenone, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2a3c89f8fcbfb6c561486d86e5a0ed2
https://doi.org/10.1111/j.1440-1819.2006.01528.x-i1
https://doi.org/10.1111/j.1440-1819.2006.01528.x-i1