Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Norimoto Gotoh"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract Retinitis pigmentosa (RP) is a heterogenous hereditary disorder leading to blindness. Despite using next-generation sequencing technologies, causal variants in about 60% of RP cases remain unknown. The heterogeneous genetic inheritance patte
Externí odkaz:
https://doaj.org/article/3f1269759009437093811c6307872aa5
Autor:
Kyoko Kawashima-Kumagai, Kenji Yamashiro, Munemitsu Yoshikawa, Masahiro Miyake, Gemmy Cheung Chui Ming, Qiao Fan, Jia Yu Koh, Masaaki Saito, Masako Sugahara-Kuroda, Maho Oishi, Yumiko Akagi-Kurashige, Isao Nakata, Hideo Nakanishi, Norimoto Gotoh, Akio Oishi, Hiroshi Tamura, Sotaro Ooto, Akitaka Tsujikawa, Yasuo Kurimoto, Tetsuju Sekiryu, Fumihiko Matsuda, Chiea-Chuen Khor, Ching-Yu Cheng, Tien Yin Wong, Nagahisa Yoshimura
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Bilateral neovascular age-related macular degeneration (AMD) causes much more handicaps for patients than unilateral neovascular AMD. Although several AMD-susceptibility genes have been evaluated for their associations to bilaterality, genom
Externí odkaz:
https://doaj.org/article/51f45ede27f14284a3b7850c22ea583a
Autor:
Kayo Shimizu, Akio Oishi, Maho Oishi, Ken Ogino, Satoshi Morooka, Masako Sugahara, Norimoto Gotoh, Nagahisa Yoshimura
Publikováno v:
Case Reports in Ophthalmology, Vol 6, Iss 2, Pp 246-250 (2015)
We screened patients with choroideremia using next-generation sequencing (NGS) and identified a novel mutation and a known mutation in the CHM gene. One patient presented an atypical fundus appearance for choroideremia. Another patient presented macu
Externí odkaz:
https://doaj.org/article/0399c1e7c09e4d7085a32488cdda0b30
Publikováno v:
Clinical Ophthalmology, Vol 2010, Iss default, Pp 793-800 (2010)
Shigeki Machida1, Tomomi Takahashi1, Norimoto Gotoh2, Nagahisa Yoshimura2, Takamitsu Fujiwara1, Dajiro Kurosaka11Department of Ophthalmology, Iwate Medical University School of Medicine, 2Department of Ophthalmology and Visual Sciences, Kyoto Univers
Externí odkaz:
https://doaj.org/article/603b968957d746969d126b0ce467a5be
Autor:
Masayuki Hata, Kazuaki Miyamoto, Akio Oishi, Yukiko Makiyama, Norimoto Gotoh, Yugo Kimura, Tadamichi Akagi, Nagahisa Yoshimura
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112403 (2014)
To compare the optic nerve head (ONH) structure between compressive optic neuropathy (CON) and glaucomatous optic neuropathy (GON), and to determine whether selected ONH quantitative parameters effectively discriminate between GON and CON, especially
Externí odkaz:
https://doaj.org/article/56780b570cdd4f6faeed9f450f90aed4
Autor:
Hong Hao, Douglas S Kim, Bernward Klocke, Kory R Johnson, Kairong Cui, Norimoto Gotoh, Chongzhi Zang, Janina Gregorski, Linn Gieser, Weiqun Peng, Yang Fann, Martin Seifert, Keji Zhao, Anand Swaroop
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002649 (2012)
A stringent control of homeostasis is critical for functional maintenance and survival of neurons. In the mammalian retina, the basic motif leucine zipper transcription factor NRL determines rod versus cone photoreceptor cell fate and activates the e
Externí odkaz:
https://doaj.org/article/00af419cad1b4925b1045418b2ca1f58
Autor:
Isao Nakata, Kenji Yamashiro, Ryo Yamada, Norimoto Gotoh, Hideo Nakanishi, Hisako Hayashi, Akitaka Tsujikawa, Atsushi Otani, Masaaki Saito, Tomohiro Iida, Akio Oishi, Keitaro Matsuo, Kazuo Tajima, Fumihiko Matsuda, Nagahisa Yoshimura
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19108 (2011)
PURPOSE: Recently, a complement component 1 inhibitor (SERPING1) gene polymorphism was identified as a novel risk factor for age-related macular degeneration (AMD) in Caucasians. We aimed to investigate whether variations in SERPING1 are associated w
Externí odkaz:
https://doaj.org/article/fe11017ae75d4dbf9c4cdb97d130cfe1
Autor:
Sunil K Parapuram, Radu I Cojocaru, Jessica R Chang, Ritu Khanna, Matthew Brooks, Mohammad Othman, Sepideh Zareparsi, Naheed W Khan, Norimoto Gotoh, Tiziana Cogliati, Anand Swaroop
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13885 (2010)
Advanced age contributes to clinical manifestations of many retinopathies and represents a major risk factor for age-related macular degeneration, a leading cause of visual impairment and blindness in the elderly. Rod photoreceptors are especially vu
Externí odkaz:
https://doaj.org/article/525a0e36e0944b94baaef16cb3f559c2
Autor:
Hideo Nakanishi, Ryo Yamada, Norimoto Gotoh, Hisako Hayashi, Kenji Yamashiro, Noriaki Shimada, Kyoko Ohno-Matsui, Manabu Mochizuki, Masaaki Saito, Tomohiro Iida, Keitaro Matsuo, Kazuo Tajima, Nagahisa Yoshimura, Fumihiko Matsuda
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000660 (2009)
Myopia is one of the most common ocular disorders worldwide. Pathological myopia, also called high myopia, comprises 1% to 5% of the general population and is one of the leading causes of legal blindness in developed countries. To identify genetic de
Externí odkaz:
https://doaj.org/article/1cdd5e4c7bc2497a81b9ff9c3ca314a4
Autor:
Akitaka Tsujikawa, Tomoko Hasegawa, Hanako Ohashi Ikeda, Norimoto Gotoh, Sachiko Iwai, Noriko Nakano, Kei Iida, Akira Kakizuka
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
In glaucoma, retinal ganglion cells are damaged, leading to the progressive constriction of the visual field. We have previously shown that the valosin-containing protein (VCP) modulators, Kyoto University Substance (KUS)121 and KUS187, prevent the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94992cbe12434bf38559d7b75e3de0ac
http://link.springer.com/article/10.1038/s41598-020-61160-6
http://link.springer.com/article/10.1038/s41598-020-61160-6