Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Norimitsu Morioka"'
Autor:
Hiroki Hashizume, Hatsune Motonari, Yoki Nakamura, Kazue Hisaoka-Nakashima, Norimitsu Morioka
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 2, Pp 103-111 (2023)
Osteoarthritis (OA) is characterized by inflammation of joints and degradation of articular cartilage matrix. As involvement of damage-associated molecular patterns (DAMPs) in the pathogenesis of OA has been reported, the present study comprehensivel
Externí odkaz:
https://doaj.org/article/9f7101b763fd4c458215337668be815c
Autor:
Momoka Iwamoto, Yoki Nakamura, Masatoshi Takemura, Kazue Hisaoka-Nakashima, Norimitsu Morioka
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 1, Pp 23-29 (2020)
Microglia maintain brain homeostasis as the main immune cells in the central nervous system. Activation of sigma-1 receptor (Sig1R) plays neuroprotective and anti-inflammatory roles in microglia. Recent studies showed that Sig1R expression level has
Externí odkaz:
https://doaj.org/article/5ad46032933a4deda8050b4c8293f5d8
Autor:
Fumiaki Sato, Yoki Nakamura, Simeng Ma, Takahiro Kochi, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Norimitsu Morioka
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112479- (2022)
Parkinson’s disease (PD) patients often complain of pain, but this problem has been neglected and is poorly understood. High mobility group box-1 (HMGB1), an alarmin/damage-associated molecular patterns protein, is increased in the cerebrospinal fl
Externí odkaz:
https://doaj.org/article/4efe221e41c54d65a4e1ceaa56261473
Autor:
Takahiro Kochi, Yoki Nakamura, Simeng Ma, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Masahiro Irifune, Norimitsu Morioka
Publikováno v:
Molecules, Vol 26, Iss 7, p 2035 (2021)
Persistent pain following orofacial surgery is not uncommon. High mobility group box 1 (HMGB1), an alarmin, is released by peripheral immune cells following nerve injury and could be related to pain associated with trigeminal nerve injury. Distal inf
Externí odkaz:
https://doaj.org/article/d0d69cededf345dd94f0e214aaee24b1
Autor:
Kazue Hisaoka-Nakashima, Honami Azuma, Fumina Ishikawa, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Yoshihiro Nakata, Norimitsu Morioka
Publikováno v:
Cells, Vol 9, Iss 5, p 1068 (2020)
A major risk factor for major depressive disorder (MDD) is stress. Stress leads to the release of high-mobility group box-1 (HMGB1), which in turn leads to neuroinflammation, a potential pathophysiological basis of MDD. The mechanism underlying stres
Externí odkaz:
https://doaj.org/article/9b72775d39374224a8124b583e0d4a58
Autor:
Kanako Miyano, Yuka Sudo, Akinobu Yokoyama, Kazue Hisaoka-Nakashima, Norimitsu Morioka, Minoru Takebayashi, Yoshihiro Nakata, Yoshikazu Higami, Yasuhito Uezono
Publikováno v:
Journal of Pharmacological Sciences, Vol 126, Iss 4, Pp 302-309 (2014)
Abstract.: The G protein–coupled receptors (GPCRs) form the largest and the most versatile superfamily that share a seven-transmembrane-spanning architecture. GPCR-signaling is involved in vision, taste, olfaction, sympathetic/parasympathetic nervo
Externí odkaz:
https://doaj.org/article/402f8861719e480aa08dad32ae234df3
Autor:
Yoki Nakamura, Hiroki Izumi, Takumi Shimizu, Kazue Hisaoka-Nakashima, Norimitsu Morioka, Yoshihiro Nakata
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 257-271 (2013)
Abstract.: To clarify a role of substance P (SP) in an endogenous pain control mechanism involving the rat striatum, striatal SP release was measured over time by microdialysis following intraplantar injection of 0.4% formalin. A slow-onset but signi
Externí odkaz:
https://doaj.org/article/e200acb09e024b889f0b3e62b79ed15d
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 3, Pp 234-245 (2010)
Astrocytes in the hypothalamic suprachiasmatic nucleus, site of the master circadian pacemaker, play an essential role in the regulation of systemic circadian rhythms. To evaluate involvement of noradrenergic systems in regulation of circadian variat
Externí odkaz:
https://doaj.org/article/b75e1a96c0e141a7934bb1cbbe19b7a1
Autor:
Katsuya Morita, Minoru Saida, Norimitsu Morioka, Tomoya Kitayama, Yasumasa Akagawa, Toshihiro Dohi
Publikováno v:
Journal of Pharmacological Sciences, Vol 106, Iss 3, Pp 492-504 (2008)
Although cyclic ADP-ribose (cADPR), a novel Ca2+-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear. The present study examined the ability of cADPR to mobilize C
Externí odkaz:
https://doaj.org/article/79f8f52cbf0d48fa9f3dd518049d6014
Autor:
He-Bin Tang, Eri Shiba, Yu-Sang Li, Norimitsu Morioka, Tai-Xing Zheng, Nobukuni Ogata, Yoshihiro Nakata
Publikováno v:
Journal of Pharmacological Sciences, Vol 108, Iss 2, Pp 190-197 (2008)
This study was conducted to determine whether Nav1.8 contributes to the release and/or synthesis of substance P (SP) in adult mice dorsal root ganglion (DRG) neurons. The SP released from cultured DRG neurons of Nav1.8 knock-out mice exposed to eithe
Externí odkaz:
https://doaj.org/article/06f793a37dce46e19c360f949c13f59d